Mauri Lab UCL

Thrilled to share our new preprint! 🎉 We uncover a novel subset of double negative (DN1) Bregs expanded in RCC, located within immature tertiary lymphoid structures, that suppress cytotoxic T cell activation. Led by @DrZaraBaig & Izzy, with support from all our collaborators.

🎉 Registrations are now open for the Exeter Immunology Symposium 2026! #EIS26 📅 Taking place on 15 & 16 June. Submit your abstract by 11 May and save with early bird rates until 27 May. Join the Southwest immunology community and register today: vist.ly/4vcfm

🧬 Research shows newborn immunity differs sharply from adults: NK cells and ILCs are functionally mature at birth, while NKT‑like cells are far less abundant and less active. Important context for understanding early‑life infection risk. 🔗 bit.ly/3JfJag1

🧪 Study shows Staphylococcus aureus exotoxin SEB can bind and activate the immune receptor 2B4, driving allergic inflammation. 2B4‑KO mice showed reduced inflammatory responses, suggesting 2B4 as a potential therapeutic target. 🔗 bit.ly/4my2B1e

New review shows how, in Sjögren’s syndrome, salivary gland epithelial cells act not just as targets but as drivers of autoimmune inflammation. Their altered signalling and antigen‑presenting features can shape and sustain immune dysregulation. 🔗 vist.ly/4v6eg

Can immune therapies move beyond disease control towards a cure? 💊 At the BSI Immune Therapies Summit, this plenary session will explore whether the immune system can be “reset” to achieve durable remission in autoimmune disease. Register today: immunetherapiessummit.cventevents.com/event/654580cb…

🔬 Open‑access study investigates how neutrophils contribute to multiple sclerosis. Using proteomics, it reveals altered granule proteins, shifts in pro‑inflammatory signalling, reduced T‑cell suppression, and enhanced Th17 differentiation in MS. Read: doi.org/10.1093/cei/ux…

3 weeks to go ⏰ On 25 March we’re marking Vaccine Engagement Day 2026! Join us to #CelebrateVaccines and highlight how vaccination protects our health and our communities. Looking for inspiration? Explore our vaccine resources 👉 bit.ly/4u8LXu9

Want to understand how the immune system works? Our ‘Foundations of immunology’ course is on 18 March. Learn the fundamentals of immunology, from immune defence to vaccines & immunotherapies. 📊 Past attendees reported a 76% increase in confidence! 🔗 bit.ly/4reoIfv

🗓️ One month to go! Vaccine Engagement Day 2026 is on 25 March. Our campaign resources are now live, so get ready to #CelebrateVaccines and highlight the vital role immunisation plays in protecting individuals & communities. 🔗 Learn more here: bit.ly/3MI35X0

Important CIDP research shows significant changes in circulating B‑cell subsets and elevated IL10/TNFA expression, correlating with disability scores and nerve fiber density. Valuable insights for understanding disease activity. 📄 bit.ly/3rzemhN

Despite elevated KLR and mitochondrial gene expression, Tregs in autoimmune PAI show normal frequency and suppressive function, suggesting limited involvement in disease pathogenesis. 📄 bit.ly/3Q2QVGU

Crohn’s disease lesions show enrichment of CD4⁺CD39⁺ TCRαβ⁺ TEM cells producing IL‑17/IL‑21 and terminally differentiated TCR Vδ1⁺ cells producing TNF‑α/IFN‑γ. Distinct inflammatory roles point to Vδ1⁺ cells as a potential therapeutic target. 📄 bit.ly/3LitpGu

MOG/NMDAR overlapping syndrome is increasingly recognised. This review shows common symptoms (psychiatric changes, seizures), typical MRI patterns, good treatment response, but a notably higher recurrence rate. Read here📄 bit.ly/3Q2S29A

🔬 Jan Devan et al. identify distinct pro‑inflammatory T‑cell populations in Crohn’s disease lesions, including CD4⁺CD39⁺ TCRαβ⁺ cells and activated TCR Vδ1⁺ cells, highlighting potential new therapeutic targets. Read the article: bit.ly/3LitpGu #CrohnsDisease

📢 We’re welcoming high‑quality translational immunology submissions! If your research offers novel mechanistic insight into human disease, we want to hear from you. Submit your work: bit.ly/3LjuI2A

🔬Maria Filika & Stergios Katsiougiannis explore how salivary gland epithelial cells in Sjögren’s syndrome actively drive and amplify autoimmune responses, reshaping how we view target tissues in autoimmunity. Read the open access review: bit.ly/4k6LOTH

This #WorldCancerDay, explore how bispecific T‑cell engagers (BiTEs) could strengthen T‑cell responses against solid tumours, and the challenges still holding them back. Read the open access review: bit.ly/4291Ipg #CancerResearch #Immunotherapy #BiTEs

Highlighting this article that explores an alternative way of assessing mTOR inhibition therapy following kidney transplantation. Read the article here: bit.ly/4kyQn9w

IFNγ from activated CD4⁺ T cells is a key driver of B‑cell differentiation and autoantibody production in IMQ‑induced lupus mice. IFNγ deficiency dramatically reduced disease features, a promising immune pathway for future SLE therapies. bit.ly/4qs1hyZ

🧬 How do we move immunosenescence research forward? Join us in Guildford this May to explore next generation technologies for studying immune ageing. The event is taking place on 20 and 21 May 2026. Submit an abstract and be part of the discussion! 🔗 bit.ly/3YGD7VW