Kyle S Smith

Many pediatric cancers are fundamentally developmental disorders. With our recent publication we have discovered the origins of medulloblastoma within the developing cerebellum. #teamscience #stjude nature.com/articles/s4158…

The Northcott lab conducted an extensive re-analysis of a single-cell transcriptional atlas of human cerebellar development originally published in 2022. During this process, we identified significant concerns related to data integrity and interpretation,

@SciPyTip Isn't scipy.sparse.sparsetools deprecated?

scipy.sparse.sparsetools contains efficient low-level routines for working with sparse matrices.

Where does medulloblastoma come from? St. Jude scientists have helped figure it out. bit.ly/3xIYo4i @drpaulnorthcott @nature #childhoodcancer #braintumor #CCAM #CancerResearch

These findings set the foundation to better model and hopefully treat these tumors going forward. So proud to be a part of this all-star team with Laure Bihannic and @B_gudenas headed by @drpaulnorthcott and @neurodevKathy

These cells are located in a region of the cerebellum known as the Rhombic Lip, which give rise to the glutamatergic neurons. Overlapping MRIs of many Group 3 and 4 medulloblastoma tumors revealed that these tumors are fully encapsulated within this region.

Many pediatric cancers are fundamentally developmental disorders. With our recent publication we have discovered the origins of medulloblastoma within the developing cerebellum. #teamscience #stjude nature.com/articles/s4158…

St. Jude scientists have discovered the developmental origins for Group 3 and Group 4 medulloblastoma which may help improve research models and potential therapeutics. bit.ly/3S2eT3J @nature @drpaulnorthcott #childhoodcancer #CCAM

1/5 Our new paper resolving the developmental origins of Group-3 Medulloblastoma is out @Nature Previously the cellular origins of Group3-MB were unknown despite multiple cross-species efforts comparing MB tumors to mouse cerebellar single-cell atlases. nature.com/articles/s4158…

UPDATE: the suspect is still at large. If you do not have to be out, stay indoors until this is resolved.

As we bid a final goodbye today we ll fondly remember Prof. Zoltan Patay for his immeasurable contributions to #pedineurorad @drmankad @StJudeResearch @The_ASPNR @ESNRad @zguroztekin @drpaulnorthcott @TYPoussaintMD @draash @hakimaalhashimi @LorenzoPinelli @nihaal08 @MirskyDavid

@fabian_theis Unipolar Brush Cells

What’s your favorite cell type?

@lab_ogden @cshperspectives For software developers it is common to have a small rubber duck to talk to when debugging a program. Sounds like this might work well for complaining about reviewers as well

Reminder: When authors are sure a reviewer is evil person X, they are usually wrong. And as editors frequently point out, when authors complain a paper should've been reviewed by nice person Y, the truth is often that it was..

@CraigHorbinski @NeurosurgeryNM @Lurieneurosurg @BrainTumorInst @NU_Pathology @neuropathology @NeuroOnc @TheUSCAP Medulloblastoma, (Group 4, subtype 8...just playing the odds on this one)

Cerebellar tumor in a 10 year-old boy. What's the most likely diagnosis? #pathology #neuropath #PathTwitter #pedipath

Excited to share our latest pre-print building a single-nucleus atlas of pediatric rhabdomyosarcoma. We report heterogeneity within 18 patient tumors, and 18 xenografts from those same patient tissues, and show treatment selects for mesoderm-like cells #sarcoma @StJudeResearch

ascopubs.org/doi/abs/10.120… Excited to have this one out, and to be part of the great clinical work being done at St. Jude.

Its going to be a crazy night! Rocking some scrabble, maybe a movie, bed by 11 @erikdauster #gangster

@erikdauster just put blanket away #StorageOttomanFTW