First total synthesis of paulomycin A — now in JACS. Rare sugar. Real synthetic challenge. Now accessible.pubs.acs.org/doi/10.1021/ja…
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Chao Li Lab
51 posts
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Thrilled to share our recent work on aliphatic radiotrifluoromethylation @ScienceMagazine. Huge kudos to my dedicated graduate student Chao Wang @VTChemDept @UcChem , and our fantastic collaborators @NIH @NIMHgov Dr. Pike, Paul, Susovan and Jinsoo. #PET science.org/doi/10.1126/sc…
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Chao Li Lab أُعيد تغريده
Cobalt-Catalyzed Photoelectrochemical Dehydration of Primary Alcohols | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…
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Chao Li Lab أُعيد تغريده
Radical Retrosynthesis of Natural Products Enabled by Iron-based Reductive Olefin Coupling. Published today in @ChemRxiv : chemrxiv.org/engage/chemrxi…
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Our Chem. Soc. Rev. Article!
Radical Retrosynthesis: A Powerful Strategy for Modern Assembly of Terpenoid Natural Products.
Modern radical chemistry—MHAT, RAE, XEC, photoredox, HAT—reshapes retrosynthetic logic for complex terpenoids.
pubs.rsc.org/en/content/art…
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Thrilled to share our progress on the synthesis of highly oxidized DMOA-derived meroterpenoids—now out in JACS:pubs.acs.org/doi/10.1021/ja…! The unexpected reaction we stumbled upon in the final step turned out to be especially fascinating.
Total Synthesis@TotalSynthesis
#TotalSynthesis of DMOA-Derived Meroterpenoids: Achieving Selectivity in the Synthesis of (+)-Berkeleyacetal D and (+)-Peniciacetal I by Jianpeng Zhang, Xiaotong Luo, Jingfu Zhang, and Chao Li @LabChao in @J_A_C_S pubs.acs.org/doi/10.1021/ja…
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@LabChao Congratulations! Very nice work. It must take a very long way to this success!
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Chao Li Lab أُعيد تغريده
Establishing the Comprehensive Structure-Activity Relationship of the Natural Antibiotic Kibdelomycin/Amycolamicin (Chao Li and co-workers) @LabChao onlinelibrary.wiley.com/doi/10.1002/an…
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We're excited to have achieved a structure-activity relationship analysis of the complex natural antibiotics Kibdelomycin/Amycolamicin through total synthesis. We hope this work will contribute to the development of new antibiotic therapies. onlinelibrary.wiley.com/doi/10.1002/an…
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Chao Li Lab أُعيد تغريده
The final version of this study was published today in @Nature : nature.com/articles/s4158…
Baran Lab@BaranLabReads
Today we report in @ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (bit.ly/3iJ61DT). In collaboration with @_chrisgparker_ and Luke Lairson the remarkable biological activity of this natural product family was revealed
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Chao Li Lab أُعيد تغريده
Excited to share our latest paper on the total synthesis of Illicium sesquiterpenes. Not only access more targets but synthetically connect distinct molecular architectures of different subfamilies through late-stage skeletal reorganization triggered by Lewis acids or oxidants.
J. Am. Chem. Soc.@J_A_C_S
Divergent Total Syntheses of Illicium Sesquiterpenes through Late-Stage Skeletal Reorganization | Journal of the American Chemical Society @CHNSci @TotalSynthesis @TotalSyntheses #Divergent #TotalSynthesis #sesquiterpenes #Rearrangement #LateStage pubs.acs.org/doi/10.1021/ja…
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Chao Li Lab أُعيد تغريده
Nickel-Catalyzed C-I-Selective C(sp2)-C(sp3) Cross-Electrophile Coupling of Bromo(iodo)arenes with Alkyl Bromides (Chao Li and co-workers) @LabChao onlinelibrary.wiley.com/doi/10.1002/an…
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Hopefully, this recent work from our group will help some medicinal chemists. A general C(sp2)–I selective C(sp2)–C(sp3) cross-electrophile coupling.
onlinelibrary.wiley.com/doi/10.1002/an…
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Chao Li Lab أُعيد تغريده
Modern alchemy appearing today in @ScienceMagazine : science.org/doi/10.1126/sc…
Commentary (thank you Prof. Ye!): science.org/doi/10.1126/sc…
Baran Lab@BaranLabReads
Modern Alchemy with rAP. Appearing today in @ChemRxiv is a solution to the longstanding (>100 year) challenge of extending the scope of the original Kolbe reaction beyond simple hydrocarbons bearing no functional groups: bit.ly/3sBQ5Ve
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Chao Li Lab أُعيد تغريده
Today we report in @ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (bit.ly/3iJ61DT). In collaboration with @_chrisgparker_ and Luke Lairson the remarkable biological activity of this natural product family was revealed
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Chao Li Lab أُعيد تغريده
Please check out our total synthesis of (−)-Peyssonnoside A @J_A_C_S. Big congratulations to Bo @BoXu44807071 and Chang!
Catalysis-Enabled 13-Step Total Synthesis of (−)-Peyssonnoside A pubs.acs.org/doi/10.1021/ja…
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Congratulations to Guangshou, and Wang lab alum Colton and Jiaqi for this work on aminofluorination, now in the JACS ASAP! ✅ doi.org/10.1021/jacs.2…
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Chao Li Lab أُعيد تغريده
Congratulations to chemist Prof. Phil Baran, who has been awarded the 2022 Danisco Foundation Science Excellence Award from @IFF. Baran is recognized for advancing science and technology relevant to the future of food, nutrition, and health magazine.scripps.edu/awards-and-hon… @BaranLabReads
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