SanthanamLab@JHUSOM

Congratulations Travis Brady @lowkeytrb! Such an honor to receive The APS Porter Fellowship!

Congratulation to Travis Brady @lowkeytrb for his award winning poster at FEBS Transglutaminase conference! @2024TGDisease

@2024TGDisease Presentation Awards - congratulations to all the awardees!

@2024TGDisease Best Poster Award! Go Travis Brady @lowkeytrb

New Research: Editorial: Cardiovascular Remodeling in Aging and Disease frontiersin.org/articles/10.33… #Physiology

Latest from the Santhanam Lab - PDGF-BB links the bone-vascular axis and promotes #vascular #aging and #arterialstiffening. pubmed.ncbi.nlm.nih.gov/34437300/ @JHACCMResearch @HopkinsACCM

@SamDasLab1: Inactivating the TN/TX miRNA-degrading enzyme blocks #VSMC stiffness and #aging-associated aortic stiffness in vivo. New target for treating large artery stiffness and #Hypertension.

Using #CRISPR -Cas9 gene editing, we created a new mouse model - the #Tgm2-C277S mouse, in which ECM remodeling and VSMC aging are uncoupled! In this model, we show VSMC aging emerges independent of ECM remodeling. @JSteppan @JHACCMResearch @HopkinsACCM

Recent studies have clearly illustrated that both vascular smooth muscle cells #VSMC and extracellular matrix #ECM are responsible for the mechanical decline of the arteries during #aging - but are they independent?

Check out the latest paper from the Santhanam Lab: nature.com/articles/s4142… Tissue #transglutaminase, best known as "meat glue" and its role in celiac disease, is an important target in organ #fibrosis and vascular #aging.

@GerechtLab @HopkinsEngineer @JHU_ChemBE @INBT_JHU @DukeEngineering @GerechtLab - will miss you terribly; but excited for your new beginning!

After 14 amazing years at @HopkinsEngineer @JHU_ChemBE, and @INBT_JHU, the Gerecht Lab will be moving to Duke BME @DukeEngineering in Jan ‘22! We visited Durham last week and are excited about what's to come!

Addressing the limitation of inability to detect LOX catalytic function associated with diverse disease processes, Wang et al. developed an in situ activity assay by utilizing the reactivity of hydrazides with imines and carbonyls. @LabSanthanam nature.com/articles/s4200…

Measure LOX activity in situ using our newly published method! rdcu.be/cnUwX @CommsBio , @JSteppan , @Huilei_Wang , @JHACCMResearch

Coming soon: A novel in situ activity assay for lysyl oxidases! Communications Biology - Nature.

Congratulations, Travis Brady, on your Ford Fellowship! bme.jhu.edu/news-events/ne…