JHU ACCM Research

It was great to return to in-person Discovery Rounds last week. Many thanks to Drs. Nikki Heller, Sam Das, and Lew Romer for their presentations. Join us for the next DR on Thursday, October 27, 2022 at 12:00pm!

20-HETE participates in intracerebral hemorrhage-induced acute injury by promoting cell ferroptosis, by Han et al. ow.ly/Q0VL50HhLTw

Does Targeted Temperature Management Improve Neurological Outcome in Extracorporeal Cardiopulmonary Resuscitation (ECPR)? by Huang et al. This systematic review showed no outcome difference between those with and without targeted temperature management. ow.ly/v88z50HhL7O

Astrocytes contribute to pain gating in the spinal cord, by Xu et al. This study introduces astrocytes as an important component of pain gating by activation of Aβ-fibers, which exert nonneuronal control of pain. ow.ly/zPBR50HhLzP

O'Brien et al. show that a resuscitation algorithm that guides changes in chest compression rate and epinephrine administration intervals based on ETCO2 level improves survival in a piglet cardiac arrest model. ow.ly/nOhj50HhM7Q

Congratulations to Dr. Roger Johns on becoming Chairman of the Board for the Foundation of Anesthesiology Education and Research.

Robert Greenberg, MD, created and published a new blog relating the experiences and perspectives of an academic pediatric anesthesiologist on ow.ly/oA7h50HhKR9. The blog, called “According to Me” in the forum, can be found here: ow.ly/zbzV50HhKR8

Check out this extensive review titled "Regulation of the cerebral circulation during development" by Dr. Ray Koehler. ow.ly/HqIb50GqGVN #ACCM

Maiga et al. report that some drug-resistance alleles impart a fitness cost to P. falciparum as shown by parasite populations after exposure to artemether-lumefantrine. Targeted chloroquine use may be warranted in areas with antimalarial drug-resistance. ow.ly/eagE50GqGhh

Grivoyannis et al. report that the introduction of neuromuscular blockade assessment appears to increase provider vigilance in dosing of NMBAs, regardless of assessment method (quantitative or subjective). ow.ly/O9zy50GqFXj #ACCM

Hong Mershon et al. showed that work on complex health care processes critical to patient safety, such as handoffs, can be performed on a national scale through cross-industry collaboration. ow.ly/orGy50GqFIs #ACCM

Findings of decreased depression scores and improved feelings of personal achievement suggest that the meditation tool Headspace® could be incorporated into the daily practice of anesthesia trainees in an effort to improve well-being. ow.ly/XJkR50GqFru #ACCM

Are you interested in diagnostic stewardship? There is variability in clinician testing practices for PICU/PCICU patients with fever. Is there a role for clinical guidelines? journals.lww.com/pqs/Fulltext/2… @JHACCMResearch #PedsICU

Back Pain in Outer Space. In this collaboration between NASA, the Dept of Defense, and Johns Hopkins, investigators explore the epidemiology, pathophysiology, prevention, and treatment of back pain during space travel. #backpain. ow.ly/qYyC50FM8TM

@SamDasLab1: Inactivating the TN/TX miRNA-degrading enzyme blocks #VSMC stiffness and #aging-associated aortic stiffness in vivo. New target for treating large artery stiffness and #Hypertension.

Check out the latest paper from the Santhanam Lab: nature.com/articles/s4142… Tissue #transglutaminase, best known as "meat glue" and its role in celiac disease, is an important target in organ #fibrosis and vascular #aging.

Inhibition of HDAC6 activity protects against endothelial dysfunction and atherogenesis in vivo: a role for HDAC6 neddylation, by Y. Nomura, M. Nakano, H. Woo Sung, M. Han, and D. Pandey. #ACCM ow.ly/MaO650FuqsG

X. Liu et al. report that bispectrical index was associated with cerebral perfusion during constant anesthetic administration, but the absolute magnitude of change in BIS as MAP decreased below the lower limit of autoregulation was small. #ACCM sciencedirect.com/science/articl…

Chronic pain: an update on burden, best practices, and new advances, by S.P. Cohen et al. ow.ly/VU1S50Fkfac

Dr. Katherine Hoops received a Small Project Award from the American Academy of Pediatrics Section on Critical Care, titled “Clinician Education on Gun Violence Prevention and Policy: Developing Continuing Medical Education Modules Based on the CONFIRM Consortium.” #ACCM