TNK effective up to 24h in non LVO AIS with salvageable brain. We knew this was coming! jamanetwork.com/journals/jama/…
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Mohana Maddula
584 posts
Mohana Maddula
@MPMaddula
Stroke & Eldercare Physician. Views are my own
Carnon Downs, England انضم Mart 2021
207 يتبع126 المتابعون
Mohana Maddula أُعيد تغريده
-short report turnaround time and closed-loop communication is necessary for relevance in hyperacute management of stroke
-delayed adoption of new technology that facilitates an emerging standard of care may create medicolegal exposure
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@ShadiYaghi2 But it may not all be about neglect. Sounds like he was pretty certain about onset time and I would’ve thought benefit of doubt ought to have gone with the patient, especially with a plumb normal NCCT
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A #stroke malpractice case where plaintiff given 40M by jury. Important to see the court records.
My reaction:
- It likely that patients with severe neglect can’t give a reliable LKWT
- CTP may not reliably measure core in hyperacute setting
expertinstitute.com/resources/insi…
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Mohana Maddula أُعيد تغريده
In a systematic review and study-level meta-analysis, TNK improved excellent functional outcomes and recanalization in AIS patients treated within 4.5-24 hours, without increasing the risks of sICH or mortality. #stroke ahajrnls.org/4nMEfSn
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@PracticalNeuro @JAMANeuro @EVToday @American_Stroke @AANmember Good to bear in mind though that study participants were a mixed bag with: carotid or intracranial artery stenosis, noncardioembolic stroke, ischemic heart disease, or peripheral artery disease.
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Adding an #antiplatelet agent to #anticoagulant therapy increased risk of bleeding while offering minimal clinical benefit for people with #ischemic #stroke, #TIA, #NVAF, & #ASCVD. Data published in @JAMANeuro.
ow.ly/tpfI50XlbkF
@EVToday @American_Stroke @AANmember
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Mohana Maddula أُعيد تغريده
🧠You can still register for the #WSC2025 Highlights Webinar — hosted by ESO, @WorldStrokeOrg and @American_Stroke. Get key updates in stroke research & care. 🔗us02web.zoom.us/webinar/regist…
#Stroke #StrokeScience #StrokeEducation #Neurology @SposatoL @eva_mistry @jeyaraj_pandian
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Mohana Maddula أُعيد تغريده
🧠Join us online on 6 Nov 2025 for a #WSC2025 Highlights Webinar — hosted by ESO, @WorldStrokeOrg and @American_Stroke. Get key updates in stroke research & care. 🔗us02web.zoom.us/webinar/regist…
#Stroke #StrokeScience #StrokeEducation #Neurology @SposatoL @eva_mistry @jeyaraj_pandian
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Would help in identification of underlying stroke mechanism and targeted secondary prevention
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Congratulations @ShadiYaghi2 on the new classification system. Specifying the minimum diagnostic work up is an important advance, and one that’ll have important resource implications for Stroke services @BIASPstroke @HargrovesDavid
Shadi Yaghi@ShadiYaghi2
The stroke field had major developments since 1993 when the TOAST criteria were proposed. We need move on to a different system that incorporates new mechanisms/tools/testing and standardizes the minimum workup. Introducing ISPS25 #stroke #WSC25 #meded ahajournals.org/doi/10.1161/ST…
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Mohana Maddula أُعيد تغريده
TNK improves excellent outcomes & recanalization in pts w/ acute stroke treated w/i 4.5-24h, w/o increasing symptomatic ICH or mortality, and provides greater additional benefits when EVT is inaccessible.🧠
shorturl.at/8IpSD
#SCCMNeuro #NeuroICU #NeuroTwitter #NeuroX
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Mohana Maddula أُعيد تغريده
#STROKE: This special report by @AmolMehtaMD et al. critically appraises recent literature on endovascular thrombectomy for medium vessel occlusion stroke and offers consideration for practice. #AHAJournals ahajrnls.org/46pRdi0
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Just when we thought TNK it is …
In patients with salvageable brain tissue identified by perfusion imaging who did not initially receive MT, alteplase given 4.5 to 24 hours after acute ischemic stroke onset improves outcomes jamanetwork.com/journals/jama/…
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Mohana Maddula أُعيد تغريده
#MondayTip
#BloodPressure management in Acute Ischemic Stroke
☝️Stability > aggressiveness
🚑Pre-reperfusion: #tolerate high BP (<185/110 if IVT, <220/120 if no reperfusion).
💉Post-reperfusion: #avoid intensive lowering, safer range is ~140–180 mmHg
🆓doi.org/10.1007/s11910…
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This is just what we need! @RCHTWeCare @Redsnapperswail
Looking forward to EoI for TASC cohort 3 from @NHSElect
David Hargroves 💙@HargrovesDavid
nhselect.nhs.uk/uploads/files/… Delighted the Thrombolysis in Acute Stroke Collaboration (TASC) tool kit is now available ☝️ 18 hospitals with low IV lysis rates @NHSEngland demonstrated phenomenal agency, learning & improvement, averaging: 45% ⬆️rates & 20mins ⬇️DTN 👏 @NHSElect
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Mohana Maddula أُعيد تغريده
Please RT and please help! @audreybowenprof @preston_jenny @CharlieChung90 @KaterinaHilari @NikolaSprigg @TheStrokeAssoc
Sandra Wydera@SWydera
Are you a UK-based clinician working with people who've had a TIA or minor stroke in the past year? Help us improve psychological care by taking part in the @OPTIMISE_study online survey. It only takes a few minutes! forms.office.com/e/RWuWQgbwYW @DrEiriniKontou @ARC_EM @InstituteMH
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Mohana Maddula أُعيد تغريده
The 2024 Lancet Commission stated that there are multiple preventable risk factors for #dementia. Addressing these factors may reduce future risk but there is a lack of interventional studies.
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Mohana Maddula أُعيد تغريده
#MondayTip
#DWI_negative AIS
📊Meta-analysis, 3,236pt➡️6.8% had clinical diagnosis of AIS w/DWI (-)
🔑Post. circulation is key: 5x greater odds of (-) DWI vs anterior strokes
⏰Timing & size matter
☝️While DWI is highly sensitive, it can still be falsely (-) in selected AIS cases
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Great to see Radiology & Stroke clinicians come together to learn about CTP. We need this for #strokecare
Thanks to all speakers and a special shout out to @rayessastroke for coming down all the way from Hull! @HargrovesDavid
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Mohana Maddula أُعيد تغريده
An underrated life lesson: Your energy creates your reality. Give your energy to stress, complaints, and negative people, they will grow. Give your energy to ambitions, gratitude, and positive people, they will grow. Your energy is your destiny. Choose wisely.
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I saw this interview last night. It was probably one of the best journalistic interviews I've seen in a long, long time.
@krishgm is brilliant, just insanely good at his job.
My only fear is that i hope he doesn't get cancelled after this.
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