Manwal Harb

Usually serum markers are detected as they are - often hard to detect, long half-life, or with high background that reduces temporal resolution. What if we could modify the markers in vivo so they can better match our needs? Introducing this concept with erasable serum markers.

What is the next frontier in brain therapy? Small molecules act everywhere; our work targets brain regions with mm precision. Next frontier? Targeting microscale - neuronal connections, ensembles. Here, we test AAV9.retro for noninvasive transduction of neuronal projections.