
Nature Biotechnology
17K posts

Nature Biotechnology
@NatureBiotech
Publishing the best of biotech science and business. Find us on Bluesky, Facebook & Instagram. Part of @SpringerNature and @NaturePortfolio.
NY/CA/London/Berlin Katılım Haziran 2009
2.6K Takip Edilen323.5K Takipçiler


Widespread DNA off-targeting confounds RNA chromatin occupancy studies go.nature.com/3Pvbf6e

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Evidence linking thymic function with health and longevity is piling up, and a cluster of biotechnology companies is trying to regenerate the thymus directly or recapitulate its function to reinvigorate patients’ immunity nature.com/articles/s4158…
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@csgarrix @kochinstitute @MITChemE @MGHCSB @BostonChildrens @harvardmed @Das_Riddha A new approach to cancer vaccination yields more powerful T cells #NBTintheNews news.mit.edu/2026/new-appro…
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Immune-remodeling mRNAs expressing IRF8 or NIK generate durable antitumor immunity in multiple cancer models go.nature.com/42td2fh

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From molecules to meaning: a search engine for the chemistry of life #NBTintheNews today.ucsd.edu/story/from-mol…
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Structure-centric searching enables global mapping of the public metabolome go.nature.com/481Sbmk

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Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery go.nature.com/3QWMRet

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Nature Biotechnology retweetledi

Are you joining us at the 2026 HCA General Meeting in 5 week’s time in Boston? If so, you’ll have the opportunity to engage directly with editors from scientific journals during ‘meet-the-editors’ sessions.
buff.ly/gnFdhAL
#HCA2026GM

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Single-cell and spatial proteomics are rapidly maturing. Yet, as measurement resolution, depth and throughput improve, progress is increasingly constrained not by experimental sensitivity but by the ability to integrate proteomic data across experiments, modalities and spatial contexts go.nature.com/3NHDkGP
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The US Supreme Court’s decision in Loper Bright, along with federal spending cuts, may limit the potential of synthetic biology to provide innovative solutions for environmental challenges, medicine and biomanufacturing go.nature.com/4cE794D
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A new translational research unit at @WeizmannScience complements the work of the technology transfer office and bridges the translation gap with strategic, operational and resource frameworks that go beyond traditional commercialization infrastructure go.nature.com/4cJwcn4
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How can we translate our growing understanding of the dark genome into therapeutics? We asked experts in the field for their thoughts go.nature.com/4tQ1zTn rdcu.be/e8Eci

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Hepatocyte detargeting improves mRNA vaccine immunity in lymphoma model #NBTintheNews via @genengnews genengnews.com/topics/drug-di…
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New research challenges understanding of mRNA vaccines and establishes innovative way to make them more effective #NBTintheNews mountsinai.org/about/newsroom…
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mRNA vaccine immunity is enhanced by hepatocyte detargeting and not dependent on dendritic cell expression go.nature.com/4eSjV0N

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Sharing of big data is a vital driver of innovation in the agri-food sector. @novonordiskfond scientists discuss the main challenges and propose steps to enhance data sharing and exploration from a research funder’s perspective go.nature.com/4raUN86
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A builder and problem solver at heart, she is developing technologies to understand and engineer the roles of cell-surface sugars, called glycans, in the immune system go.nature.com/42sA99y
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Progress toward a true virtual cell will depend on uniting AI’s pattern-finding power with the causal rigor of mechanistic models go.nature.com/48muYvd
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Nature Biotechnology retweetledi
Nature Biotechnology retweetledi

What if you could test a drug on a human organ and simultaneously know what would have happened without it?
That's what we built.
Proud to share our work in @NatureBiotech: digital twins of human lungs 🫁🔥 (paper: nature.com/articles/s4158…)
We created digital twins of ex vivo human lungs: multimodal AI models trained on 951 human lungs from the world's largest EVLP dataset at @UHN. Physics-informed ML across physiology, biochemistry, transcriptomics, proteomics, metabolomics, and imaging, all forecasting together.
The key insight: the physical lung receives the treatment. The twin is the untreated control. Paired causal inference on the same organ. No separate cohort. No intersubject noise.
Result: we detected drug efficacy with 6 lungs. Traditional methods would need 18.
This is what precision preclinical evaluation looks like.
From Virtual Cells → Virtual Organs → Virtual Patients.
One step toward virtual organs replacing animal testing.
Huge congratulations to Elly Zhou (a phd student I co-supervise) for leading this work with exceptional rigor, and to Andrew Sage and @SKeshavjee for building the foundation that made it possible.

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Nature Biotechnology retweetledi

1/ Our most recent Inside Valence blog post delves into TxPert, a SOTA model published in @NatureBiotech.
The key finding: scale alone is insufficient, even smaller model architectures can achieve top performance when coupled with biological priors.
@IhabBendid35780

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