Nature Biotechnology

🚨SAVE THE DATE! 5th Synthetic Biology of Natural Products Conference 📅Date: 01 - 04 November 2026 🌏Location: Playa del Carmen, Mexico 📢Early Bird & Talk Submission: 04 May 2026 Don't miss out, Register now ➡️bit.ly/48K3qk9 #SBNP #FusionGenomics #FusionMolBio #FusionBioChem

In Brief: @US_FDA changes its stance and agrees to review @moderna_tx’s mRNA flu vaccine after the biotech amends its Biologics License Application nature.com/articles/s4158… rdcu.be/e83HZ

Curing the bystander effect: a new base editing tool minimizes unwanted edits to DNA #NBTintheNews via @UCSanDiego today.ucsd.edu/story/curing-t…

Precise, minimally evolved adenine base editors generated through mutation reversion analysis go.nature.com/4rHWkmu

@PKU1898 @astar_research @ASTARsg Research Briefing: An engineered E. coli strain sustains intratumoral nitric oxide production to boost effectiveness of tumor immunotherapy nature.com/articles/s4158… rdcu.be/e80pQ

Sustained nitric oxide production by engineered E. coli remodels the tumor microenvironment and potentiates immunotherapy - @PKU1898 go.nature.com/4sk7MpB

A decade of research in review For Nature Biotechnology’s 30th anniversary, our editors look back at a few of their favorite papers published in the past decade go.nature.com/4sWhZs1

Genome editing’s third act nature.com/articles/s4158… [🔓read free with login]

Combining optimized AAVs and enveloped delivery vehicles enable in vivo CAR‑T cell generation by integrating a CAR transgene into a T cell–specific locus. #NBThighlight nature.com/articles/s4158…

Research Highlight: In vivo base editing reverses a neurodevelopmental disorder nature.com/articles/s4158…

In vivo base editing restores a neurodevelopmental disorder in mice #NBThighlight nature.com/articles/s4158…

Single-molecule peptide sequencing through reverse translation of peptides into DNA go.nature.com/4sRPr2K

Mitigating the negative environmental effects imposed by agri-food systems demands a much better understanding and management of the ecosystems and value chains on which our food production depends. Such a development in farming and food production requires extensive use and understanding of agri-food big data go.nature.com/4raUN86 rdcu.be/e8Ef7

Transposable elements, such as retrotransposons and endogenous retroviruses, are increasingly recognized for their important roles in genome function and impact on disease development go.nature.com/4tQ1zTn rdcu.be/e8Eci

30 years of Nature Biotechnology go.nature.com/4sLrzhi

The March issue is live nature.com/nbt/volumes/44… On the cover, Chen et al. engineered TadA-derived mitochondrial DNA adenine base editors for efficient mtDNA A-to-G editing with expanded targeting scopes and minimal off-target effects. This robust editing approach led to the successful generation of mitochondrial disease models go.nature.com/3TaxaOg go.nature.com/4dHqZea

AI turbocharges antibody hunt for binders with drug-like qualities nature.com/articles/s4158… [🔓read free with login]

#NBTintheNews x.com/NewYorker/stat…

Next-generation psychedelics: should new agents skip the trip? nature.com/articles/s4158…

We're seeking an Interim Associate or Senior Reviews Editor to join our editorial team, working across all aspects of the journal, commissioning Reviews, Perspectives and opinion pieces, and providing detailed developmental and line-by-line editing. This is a 12-month, full-time contract and can be based in our Berlin or Heidelberg offices springernature.wd3.myworkdayjobs.com/en-US/Springer…

Manufacturing-aware generative models enable petascale synthesis of designed DNA go.nature.com/3NxXt1I

Gene-based therapies poised for major upgrade thanks to Oregon State University research #NBTintheNews news.oregonstate.edu/news/gene-base…

In vivo endosomal escape assay identifies mechanisms for efficient hepatic LNP delivery go.nature.com/4usXJ2U