A long-chased dream reaction, enantioselective nucleophilic C-H fluorination is unlocked by our ligand design under Pd catalysis, enabling rapid diversification of drug-like molecules and radiolabelling for PET. Huge thanks to @scrippsresearch and @bmsnews for continuous support!
Scripps Research@scrippsresearch
The @YulabJin reports a one-step method to stereoselectively attach fluorine to drug-like molecules using low-cost fluoride. Published in @NatureCatalysis with first author @NikChekshin and @bmsnews, the approach uses fluorine-18 for PET imaging to track bioactive compounds and accelerate drug discovery. More: ow.ly/kttg50XHyPg
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