Shenvi Lab

If you like total synthesis and Wordle, check out Synthordle, a retrosynthetic analysis game created by Shenvi Lab associates Kevin Zong (GS 2) and Jonah Luo (HS sophomore!). rshenvi.github.io/synthordle/ Coming to @scrippsresearch Chemical Synthesis class in Winter ’25.

Congrats to Dylan and Stephen for their method to glycosylate cotylenol and access 14-3-3 protein-client molecular glues! tinyurl.com/2y45ck4n Donor linker design was aided by Stephen’s “autoDFT” and solved a common problem in terpenoid synthesis: contrasteric glycosylation.

In this paper, 3rd year graduate student 李春雨 (Chunyu Li) synthesized 25 natural products (!!) using a method of in silico library selection. Chunyu is a new type of student in our lab, having seamlessly blended calculation and synthesis. Take a look: tinyurl.com/mryjxh2w

Meet Stephan Freeman, #ARCSScholar @Shenvi_Lab @scrippsresearch where he is helping to develop new tools to access ‘natural product space,’ compounds typified by cellular metabolites. Stephan will be honored at our 2024 SOY Celebration in April. More info: san-diego.arcsfoundation.org/2024-SOY-Celeb…

I feel very honored to be recognized with this Rising Star Award. It would not have been possible without help from fantastic students, postdocs, collaborators, and colleagues.

This protocol saved my day a few years ago and works amazingly for even the trickiest olefin isomerisations!

Ever wanted 3 grams of (–)-humulene oxide II? Neither did we. But OrgSyn came knocking and we couldn’t say no. orgsyn.org/Content/pdfs/p… Thanks for checking, @sarah_reisman and Emily Chen! #tbt Original gram-scale protocol in our JACS 2014 16788 paper.

Scripps Research chemists Ryan Shenvi and Guanghu Tong in the @Shenvi_Lab have modified the traditional poison picrotoxinin, significantly improving its stability and safety for potential neurological drugs, pesticides and anti-parasite treatments. ow.ly/wg3n50QkPa8

📢 *Calling all budding chemical biologist* Consider applying to the Program in Chemical Biology @UMich for your PhD!! Please reach out with any questions about this exceptional program.

#2: Had a blast collaborating with @BaranLabReads. Felt like old times. tinyurl.com/7heyrvka We report a single catalyst that quaternizes 3° radicals derived from RAEs or olefins. Very simple conditions: iron, reductant, base.

2 papers posted today. #1 reports heterodimerization of benzyl radicals, generated and coupled by a single catalyst. tinyurl.com/2ej7zu3x The iron complex engages an alkene in two outer-sphere steps, in contrast to inner-sphere steps of precious metals. Congrats to the team!

@aplooby28 @scrippsresearch Had a great time chatting with you, Aidan. Thanks for the invitation! Next time let’s talk about your science!

On today's episode, I am joined by @Shenvi_Lab of @scrippsresearch! We talk natural product synthesis, metal-hydride hydrogen atom transfer, the large overlap between writing music and organic synthesis, and much more.

Spread the word! Come be our colleague! Scripps Chemistry is searching for a Tenure-Track Assistant Professor with a focus on organic chemistry and synthesis, broadly defined.

Fall fashions have arrived. Inner-sphere is out, outer-sphere is in. A new @ACSPublications Accounts from @__simonalisa__ summarizes our group's development of first-row metal catalysis to enable fragment coupling en route to bioactive natural products. tinyurl.com/bde8pfs4

The final version of this Preprint has been published today in @ACSCentSci : pubs.acs.org/doi/10.1021/ac…

Hi everyone! My PhD defense will be taking place this Thursday, October 12th at 9am PST. If you're interested in tuning in, you can find the zoom link below: scripps.zoom.us/j/97225538624

Salvaging Salvinorin: From Hallucinogen to Potential Therapeutic through Chemical Synthesis Read it here: go.acs.org/6bj NEW First Reactions by Myles Smith & Bhawyanth Duvvuru @UTSWNews discussing work by @Shenvi_Lab @LauraMBohnPhD1 & co-workers go.acs.org/6bk

@yujikamei (btw, that was a note from the PI!)

@yujikamei Thank you but the real heroes are at the hoods - PIs are just more visible!

I attended #efmcasmc23 in Zagreb this week. The conference was fantastic and it was great meeting Prof. Shenvi @Shenvi_Lab !! He is my hero! Also, I presented a poster!

Happy to share this total synthesis: not the end, but only the beginning. pubs.acs.org/doi/10.1021/ja…