Science Translational Medicine

A new #AI-based risk model for #BreastCancer that harnesses digital mammograms shows promise for primary prevention when applied to identify 10-year risk in cohorts in the U.S. and Sweden, and outperforms clinical models and the Mirai tool. @ki_meb_biostat scim.ag/4f2omqa

By encapsulating an engineered CRISPR-Cas12 therapeutic in a #PhageTherapy delivery system, a team designs a precision antimicrobial therapy for Shiga toxin-producing #Ecoli that cleaves the Stx gene and combats infection in animals. @dbikard @EligoBio scim.ag/4u3Ecob

A rapid manufacturing pipeline for BCMA-targeting #CARTcells drastically shortens “vein-to-vein” times, and produces cells that demonstrate encouraging safety results in a phase one trial of patients with relapsed #MultipleMyeloma. @DanaFarber scim.ag/4nVUU7E

A creative CRISPR-phage therapy targets toxic E. coli infections untreatable with antibiotics in mice, a rapid production platform for CAR T cells shows promise in patients with multiple myeloma, and more this week in #ScienceTranslationalMedicine. scim.ag/4dRg3et

A four-dimensional biosensor can track disruptions in #autophagy flux within beta cells in real time and show these precede the onset of autoimmune #diabetes, offering a useful tool for beta cell and type 1 diabetes research. @LinnemannLab @IUDeptPeds scim.ag/4nGBvHs

A new generation of therapies that targets the brain-immune system axis stands to reshape the treatment of neurodegenerative disorders such as #AlzheimersDisease, scientists argue in a new Viewpoint. @WeizmannScience scim.ag/4dUSLWh

A new #AI-based risk model for #BreastCancer that harnesses digital mammograms shows promise for primary prevention when applied to identify 10-year risk in cohorts in the US and Sweden, and outperforms clinical models and the Mirai tool. @ki_meb_biostat scim.ag/4f2omqa

A multiplexed platform named NeuroSense enables near real-time monitoring of CSF biomarkers in patients in the neurological ICU, potentially supporting timelier diagnosis and intervention. @Mahla_Poudineh @ShriyaSrinivas3 @jbernstock1 @WaterlooENG scim.ag/3Pg8xBK

A fluorescent reporter for #KidneyFibrosis that sniffs out elevated TG2 can detect fibrotic hallmarks and distinguish mild and severe cases in mice and a small cohort via urinalysis. @sysu_1924 scim.ag/4dYoyWj

New research identifies a subset of #BetaCells that produce mitochondrial reactive oxygen species in response to IFN-alpha—and shows this antiviral response is diminished in patients with #Type1Diabetes. @IUSM_Biochem @LinnemannLab @IUDeptPeds scim.ag/4nJpFwc

Don't miss the new issue of #ScienceTranslationalMedicine! A long-term AI risk model for breast cancer shows promise in primary prevention, next-generation imaging molecules could realize noninvasive tests for kidney fibrosis, and more. scim.ag/4eSv6GY

A new study employs AAV vectors and RNA-lipid nanoparticles to deliver a prime editor to correct citrullinemia type I in neonatal and juvenile mice, highlighting the technology’s potential for genetic liver disorders. @schwanklab @UZH_IPT #GeneTherapy scim.ag/49BakIl

Prime editing that targets a mutant allele in the gene SCN1A achieves efficient editing and reduces the frequency of febrile seizures in a mouse model of generalized epilepsy with febrile seizures plus (#GEFS+). @schwanklab @KisslingLucas @UZH_IPT scim.ag/4dsybLG

Leveraging adenine #BaseEditing, researchers demonstrate high editing efficiency of mutant SCN1A in a newborn mouse model of #DravetSyndrome and show it can lower seizure frequency while boosting survival. @davidrliu @broadinstitute scim.ag/4tBdXVM

A clinical trial of infants living with #HIV shows that broadly neutralizing antibodies are safe when combined with early antiretroviral therapy, underscoring the need for dedicated pediatric trials in the quest for ART-free remission. @IUDeptPeds scim.ag/4ezoPjg

Congrats to the Sunwoo Lab for their recent publication in @ScienceTM! 👏🔬 The @JohnSunwooMD Lab and collaborators, including Dr. Jennifer @FoltzPhd at Wash U, have identified a cytotoxic tissue-resident NK cell subset, characterized by the expression of CD39, CD49a, and CD103.

I'm very excited to see this work published in @ScienceTM . Proteogenomic studies have grown very rapidly in plasma, with almost every other context being completely ignored along the way. We find that even within closely related contexts (plasma and CSF), (1/3)

@DanWestern2 new @ScienceTM paper (science.org/doi/10.1126/sc…) demonstrates that CSF proteogenomics captures disease‑relevant pathways missed in plasma, uncovering 400+ protein–trait associations across AD, PD, MS, and psychiatric disorders. Less accessible ≠ less important.

Excited to share our paper in @ScienceTM! Together with @Francesca_Pietr as co-first author, we used in vivo prime editing to correct a pathogenic SCN1A mutation in a GEFS+ mouse model. Huge thanks to all co-authors for their work! doi.org/10.1126/scitra…

Our latest paper is out @ScienceTM! Natural killer cell immunotherapy reverses lung fibrosis by eliminating senescent fibroblasts | Science Translational Medicine science.org/doi/10.1126/sc… #Immunotherapy #Fibrosis #Aging #Senescence #NKcell