Science Translational Medicine

A longitudinal analysis of patients with #ColorectalCancer ties lower development of premalignant polyps to robust adaptive immune surveillance and elevated noncoding RNA—decrypting how the immune microenvironment shapes early carcinogenesis. @Inserm scim.ag/3Q9obPM

Using chlorpromazine and promethazine to induce #hypothermia, researchers find they can lower metabolism and body temperature to protect large animals from #stroke—and show the combo is safe in a phase one clinical trial. scim.ag/4fPXjyJ

A #MachineLearning model based on 11 plasma protein markers predicts the risk of #thrombosis in patients with #cancer more accurately than standard risk scores, and uncovers IL-17A as a potential therapeutic target. @jzbos @ioavlachos @BIDMChealth scim.ag/4vkCkZO

This week's issue of #ScienceTranslationalMedicine has arrived! A deep learning pipeline accelerates antibiotic discovery for drug-resistant gonorrhea, scientists mimic the effects of hypothermia to protect against stroke in animals, and more. scim.ag/4a5AqDP

An antimalaria compound from the pyrrolidinamide class of drugs is safe in humans and displays promising potency and parasite killing kinetics against #Pfalciparum in a volunteer challenge study. @QIMRB_Institute scim.ag/4gh1HH4

Using humanized mice, researchers isolate neutralizing antibodies against #Nipah and Hendra virus that shield rodents from infections, identifying a potential antibody cocktail for deadly emerging henipaviruses. @VirusWhisperer @IcahnMountSinai scim.ag/4uQToWl

A landmark study shows that latent #HIV can convert CD4+ T cells to CD8+ T cells and identifies the latter as a previously overlooked component of the viral reservoir—a surprising finding with critical implications for HIV cure efforts. @sysu_1924 scim.ag/4uklbhB

It takes a Village. Could not have done this without the resources and intellectual camaraderie at @IcahnMountSinai #Microbiology, the clever perseverance of Axel Guzman-Solis, and the generous collaborators from across the country and in the U.K. 1/ What if we could stop a deadly virus not by blocking one doorway, but by locking two at once? New in @ScienceTM: our team developed a two-antibody strategy against Nipah and Hendra viruses, two bat-borne paramyxoviruses with pandemic potential. science.org/eprint/F8QDVNK…. #ScienceTranslationalMedicineResearch

A whole genome sequencing assay named HPV-DeepSeek sniffs out signs of residual disease after surgery in patients with #HPV+ head and neck cancer, and detects recurrence earlier than digital PCR and standard clinical criteria. @FadenLab @BIDharvardOHNS scim.ag/3S52VLF

Big day for our lab! New paper using our HPV-DeepSeek assay, an ultrasensitive HPV WGS-based liquid biopsy for MRD detection in HPV+ head & neck cancer, is out today in @ScienceTM 🧵 🔗 science.org/doi/10.1126/sc…

A longitudinal analysis of patients with #ColorectalCancer ties lower development of premalignant polyps to robust adaptive immune surveillance and elevated noncoding RNA—decrypting how the immune microenvironment shapes early carcinogenesis. @Inserm scim.ag/3Q9obPM

This week's issue of #ScienceTranslationalMedicine is out! A whole-genome test catches residual disease earlier in patients with HPV-linked head and neck cancer, research reveals how immunity influences the premalignant origins of colon cancer, and more. scim.ag/4dZi0ab

A landmark study shows that latent #HIV can convert CD4+ T cells to CD8+ T cells and identifies the latter as a previously overlooked component of the viral reservoir—a surprising finding with critical implications for HIV cure efforts. @sysu_1924 scim.ag/4uklbhB

New work links idiopathic #PulmonaryFibrosis in patients to TLR5 deficiency, which disrupts the lung #microbiome, and shows TLR5 agonists can modulate microbial diversity to protect against the onset of fibrosis in mice. @IRPatNIH scim.ag/4vA7fkA

By encapsulating an engineered CRISPR-Cas12 therapeutic in a #PhageTherapy delivery system, a team designs a precision antimicrobial therapy for Shiga toxin-producing #Ecoli that cleaves the Stx gene and combats infection in animals. @dbikard @EligoBio scim.ag/4u3Ecob

A new #CryoEM analysis decrypts the structure and neutralizing capabilities of monoclonal antibodies against #enterovirus D68 elicited by VLP vaccination in macaques, underscoring the clinical promise of these immunizations. @NIAIDNews scim.ag/4oglb0I

A landmark study shows that latent #HIV can convert CD4+ T cells to CD8+ T cells and identifies the latter as a previously overlooked component of the viral reservoir—a surprising finding with critical implications for HIV cure efforts. @sysu_1924 scim.ag/4uklbhB

The new issue of #ScienceTranslationalMedicine has arrived! A landmark study reveals the HIV T cell reservoir is broader and more plastic than previously thought, restoring the lung microbiome may help to treat idiopathic pulmonary fibrosis, and more. scim.ag/4dL37Ih

A rapid manufacturing pipeline for BCMA-targeting #CARTcells drastically shortens “vein-to-vein” times, and produces cells that demonstrate encouraging safety results in a phase one trial of patients with relapsed #MultipleMyeloma. @DanaFarber scim.ag/4nVUU7E

New #GeneEditing systems named PRINCE and Little Prince employ small molecules to control both nuclease and guide RNAs—achieving precise control over the duration of gene editing and reducing off-target edits in mouse models. @Shenzhensuat_sz scim.ag/4nXF2Bp