Science Translational Medicine

A population of highly active and primed cytotoxic CD4+ T cells in the liver may be key to functional cure of chronic #HepatitisB and antigen clearance, according to new research involving mice and patient samples. @GabiFragiadakis @UCSFMedicine scim.ag/4cM4UfG

Scientists build an atlas of the blood vessel in #diabetes and decipher crosstalk between “foamy” phagocytes and endothelial cells, showing that TREM2 drives vessel dysfunction in peripheral artery disease. @ZhenBoumanChen @NMalhi92 @cityofhope scim.ag/4mKxzFi

This week, researchers leverage adeno-associated vectors to deliver the CCR5-blocking HIV drug #leronlimab and show that a single dose elicits leronlimab expression and can partially suppress SHIV in infected macaques for as long as one year. @OHSUNews scim.ag/4cUEPd5

A longitudinal study of #influenza vaccinees reveals that #FluMist—the only FDA-approved intranasal flu vaccine—promotes robust memory B cell responses in the upper respiratory tract that persist for 6 months. @profshanecrotty @Hannah_Stacey_ @ljiresearch scim.ag/49e3EQ6

A clinical study shows how the intranasal FluMist vaccine can elicit potent antiflu immunity at mucosal sites, researchers tie persistent T cells in the liver to clinical cure of chronic hepatitis B, and more this week in #ScienceTranslationalMedicine. scim.ag/4dfPQ9l

An optimized adenine #BaseEditing strategy can repair the “untreatable” 1717-1G>A #CysticFibrosis mutation in cells and organoids with potentially promising efficiency rates and little off-target editing, according to new work. @CIBIOcrispr @UniTrento scim.ag/41US5cH

Scientists build an atlas of the blood vessel in #diabetes and decipher crosstalk between “foamy” phagocytes and endothelial cells, showing that TREM2 drives vessel dysfunction in peripheral artery disease. @ZhenBoumanChen @NMalhi92 @cityofhope scim.ag/4mKxzFi

Analyzing unique patient specimens from height-limiting surgery, researchers dissect the molecular architecture of the pubertal #GrowthPlate, identify distinct stem cell populations, and characterize the effects of growth hormone. @SahlgrenskaAcad scim.ag/3Q7DdVT

An optimized adenine #BaseEditing strategy can repair the “untreatable” 1717-1G>A #CysticFibrosis mutation in cells and organoids with potentially promising efficiency rates and little off-target editing, according to new work. @CIBIOcrispr @UniTrento scim.ag/41US5cH

Scientists build an atlas of the blood vessel in #diabetes and decipher crosstalk between “foamy” phagocytes and endothelial cells, showing that TREM2 drives vessel dysfunction in peripheral artery disease. @ZhenBoumanChen @NMalhi92 @cityofhope scim.ag/4mKxzFi

This week's new issue of #ScienceTranslationalMedicine has arrived! An atlas of cellular crosstalk deciphers the origins of blood vessel damage in diabetes, a new gene therapy can repair an "untreatable" cystic fibrosis mutation in cells, and more. scim.ag/41MrRcu

Analyzing unique patient specimens from height-limiting surgery, researchers dissect the molecular architecture of the pubertal #GrowthPlate, identify distinct stem cell populations, and characterize the effects of growth hormone. @SahlgrenskaAcad scim.ag/3Q7DdVT

The orphan receptor GPR84 is a chief culprit behind proinflammatory signaling that drives #BuruliUlcer, according to work in mice that shows it offers a target for host-directed therapies for this neglected tropical disease. @Me_Foulon @Ch_Bioch_UNIGE scim.ag/3OoLtjM

A smart contact lens can monitor and manage intraocular pressure in animals in real time by releasing #glaucoma drugs without bulky electronics, achieving a low-cost therapeutic and diagnostic tool for personalized ocular care. @yangzhi_zhu @TerasakiInst scim.ag/4tHPizD

The experimental small-molecule inhibitor ARN-75039 offers strong protection against #LassaVirus infection in guinea pigs at varying dosing schedules and when given as long as 7 days postexposure, according to new work. @NIAIDNews scim.ag/4cQgpTf

Analyzing unique patient specimens from height-limiting surgery, researchers dissect the molecular architecture of the pubertal #GrowthPlate, identify distinct stem cell populations, and characterize the effects of growth hormone. @SahlgrenskaAcad scim.ag/3Q7DdVT

This week's issue of #ScienceTranslationalMedicine has arrived! Unique patient samples help to decipher the complex architecture of growth plates during puberty, an experimental oral compound shields guinea pigs from Lassa virus, and more. scim.ag/4mA9wc7

New work reveals how loss of keratin 16 aggravates skin inflammation and lesions in mice by impairing crosstalk between #keratinocytes and neutrophils, potentially informing therapeutics for disorders like #PachyonychiaCongenita. @PierreCoulombe8 @UMCDB scim.ag/4ty4LSy

By amalgamating domains from the entry receptors of VEEV, EEEV, and WEEV, researchers engineer a decoy chimeric protein that neutralizes all three #alphaviruses and can shield mice from infection. @sathvikpal @msdiamondlab @washu_pathology scim.ag/4vnUqdJ

By analyzing a “time capsule” of historic samples from recipients of a 1994 #influenza vaccine, a team defines the breadth of antibody and B cell responses to future, emerging influenza A and B. @kedzierskalab @TheDohertyInst @WheatleyAtotheK @AmyWChung scim.ag/3NFiOXp