Nano Bio Optics Lab (Yoav Shechtman)

249 posts

Nano Bio Optics Lab (Yoav Shechtman)

@ShechtmanLab

We develop microscopy methods to observe life on the nanoscale

Israel انضم Aralık 2015

294 يتبع1K المتابعون

Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·21 Eki

Gen-AI producing fancy data augmentation for Super-resolution microscopy! Great work @AlonSaguy and team! @HenriquesLab @HeilemannLab

Ricardo Henriques@HenriquesLab

If robots could dream of microtubules, how would they look like? An amazing story by Alon Saguy, @ShechtmanLab and colleagues. Proud we could contribute to it onlinelibrary.wiley.com/doi/10.1002/sm…

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·17 Tem

@hagenom Great - congrats!

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Yuval Ebenstein@hagenom·16 Tem

Happy to tell that our our startup, Medical Diagnostics Company, JaxBio Technologies, Secures €2.5 Million Grant from European Innovation Council Accelerator prweb.com/releases/medic…

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·9 Tem

@BejaLab @EMBO @BiologyTechnion Congratulations!

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·9 Tem

@rolls_asya @EMBO Great, congrats!

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Asya Rolls@rolls_asya·9 Tem

Thank you @EMBO for this great opportunity to be part of this amazing community

EMBO@EMBO

Outstanding scientists elected to EMBO Membership: in EMBO’s 60th anniversary year, 100 new members and 20 associate members join the community embo.org/press-releases…

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·9 Tem

@HenriquesLab @EMBO Awesome, congrats!

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Ricardo Henriques@HenriquesLab·9 Tem

🔬🎉 Grateful for being elected an @EMBO member. A testament to the hard work and support of the entire lab team over the years 😍. Looking forward to interact even more with the brilliant community and continue to help the next generation of outstanding scientists

EMBO@EMBO

Outstanding scientists elected to EMBO Membership: in EMBO’s 60th anniversary year, 100 new members and 20 associate members join the community embo.org/press-releases…

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·21 Haz

Great work @yevgenin @DanielleSapir et al.!

Yevgeni Nogin@yevgenin

Thrilled to share OM2Seq! We applied #AI methods to #Genomics, improving the speed and accuracy of optical genome mapping for fast diagnostics of diseases. @DanielleSapir, Tahir Detinis Zur, Nir Weinberger, @boknilev, @hagenom, @ShechtmanLab 🔬🚀

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·8 Haz

We used the Incucyte system by @SartoriusGlobal. All this and more in our latest paper: link.springer.com/article/10.103…. Big thanks and congrats to all co-authors and collaborators: Nadav, @EliasNehme9 Noam, Ilana, Reut, Boris, Paul, @AlaloufOnit , @SartoriusGlobal !

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·8 Haz

This enables PSF engineering in space-limited microscopy systems, e.g. that fit into incubators. Uses include extended depth-of-field and snapshot 3D spheroid from 2D, using algorithms by @EliasNehme9. Bonus: Obtaining training images is easy with a high-throughput microscope.

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·8 Haz

PSF engineering typically requires a 4-f system, but this is not always feasible, e.g. due to size constraints. Nadav Opatovski attached a phase mask directly to the objective lens, see beads defocusing here. Tetrapod mask shown here (wait for the end):

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·9 May

@Ella_Maru @naturemethods @AlonSaguy @AlaloufOnit @HeilemannLab Thanks! Re simultaneous processes - there will be a complexity-performance tradeoff that would be interesting to check (TBD). Of course if the processes are labeled orthogonally (e.g. different colors) then each one will just be solved separately.

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Ella Marushchenko@Ella_Maru·14 Nis

@ShechtmanLab @naturemethods @AlonSaguy @AlaloufOnit @HeilemannLab Congratulations on groundbreaking advancement! How does DBlink perform in dense, complex cellular environments with multiple simultaneous dynamic processes?

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·27 Tem

🥳 DBlink is now peer reviewed and improved! Online in @naturemethods: rdcu.be/dhUmZ Congrats @AlonSaguy, @AlaloufOnit, @HeilemannLab et al.!

Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab

New prepint just out! Live cell single molecule localization microscopy at >3 fps. The information is mostly there - just spread out in space and time :) We use a recurrent neural net (LSTM) + some assumptions to extract it. All details here: biorxiv.org/content/10.110…

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·8 Tem

More info in the preprint: biorxiv.org/content/10.110………, where we demonstrate the use-case of generating training data for CARE (by @martweig et al.) 3/4

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·8 Tem

Alon Saguy et al. trained a diffusion model to generate synthetic images of super-resolution microscopy images using data of only a few images from ShareLoc (shareloc.xyz). 2/4

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·8 Tem

One of these super-resolution microtubule images was captured by a microscope and the other one was generated by a diffusion model. Can you tell which is which? Try more here: clever-microscopy.com/this-microtubu… 1/4

Nano Bio Optics Lab (Yoav Shechtman) tweet media

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·8 Tem

This is a very ongoing project, with many open questions: what are the performance limits? How much can we really gain beyond the information in the training data? and of course: what would be the best uses of something like this in super-resolution microscopy? 4/4

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·27 Haz

@christlet Interesting. Do you also get blinking-pairs mistaken for a vertically-elongated PSF (high Z)? I would expect to see a similar number of those.

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·5 Haz

@AmitZeisel @eLife @_delkind_ @OpenU_Israel Congratulations!

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Amit Zeisel@AmitZeisel·5 Haz

I’m very happy to share that our article “Sex, strain, and lateral differences in brain cytoarchitecture across a large mouse population” is now out in @eLife Congrats to study leader David Elkind(@_delkind_), my collaborator Noam Shental @OpenU_Israel, and all contributors.

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·5 Haz

@dvir_a @AmitZeisel @eLife @_delkind_ @OpenU_Israel 🤐

QME

Dvir Aran@dvir_a·5 Haz

@AmitZeisel @eLife @_delkind_ @OpenU_Israel @ShechtmanLab please don’t tweet on new publications in the near future. My 8th floor ego won’t be able to bear it :)

Chicago, IL 🇺🇸 English

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·2 Haz

@stern_lab @eLife Congrats!!

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Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·29 May

Great work by @yevgenin applying information theory to optical genome mapping, with implications to optimal label design

Yevgeni Nogin@yevgenin

New #preprint! TLDR: Applying #informationtheory on #OpticalGenomeMapping🧬, one can choose pattern-labelling #enzymes giving #10x accuracy! 🤯 biorxiv.org/content/10.110… To illustrate, let’s play a game! ⬇️ (1/4)

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اكتشف

@AlonSaguy @HenriquesLab @HeilemannLab @hagenom @EMBO @BiologyTechnion @rolls_asya @yevgenin