Jake Wintermute 🧬/acc

12.1K posts

Jake Wintermute 🧬/acc banner
Jake Wintermute 🧬/acc

Jake Wintermute 🧬/acc

@SynBio1

Synthetic Biologist - Foundry Theorist - stay humble biodesigners

Cambridge, MA انضم Haziran 2014
404 يتبع15.8K المتابعون
تغريدة مثبتة
Jake Wintermute 🧬/acc
Jake Wintermute 🧬/acc@SynBio1·
Stop glamorizing the hustle and start glamorizing the mussel
Jake Wintermute 🧬/acc tweet media
English
103
4K
40.4K
0
Jake Wintermute 🧬/acc أُعيد تغريده
Michael Baym
Michael Baym@baym·
Modern bio can only dream of tech as deep as citrus
Michael Baym tweet media
English
22
248
2.2K
35.4K
Mukesh Prasad
Mukesh Prasad@MPrasad65824·
@SynBio1 "This is the core problem of the next 5 years in the AI scientist era: infinite hypotheses about which nobody cares" That sounds like a great hypothesis! Did you find out if anybody cares?
English
1
0
5
311
Joe McAuliffe
Joe McAuliffe@JoeMcAuliffe17·
@ProfTomEllis @SynBio1 If you can’t get patent protection then your entire value proposition is at risk. Of course a drugs has to be safe and effective as well, but the reality is that drug development requires millions of investor dollars.
English
1
0
1
46
Tom Ellis
Tom Ellis@ProfTomEllis·
Okay here's a game - you're making nanobody therapeutics. AI can help you optimise them, but you need to prioritise order of feature importance. What is your order? Affinity Specificity Expressibility Clinical toxicity In vivo stability Purified stability Patentability Other?
English
12
2
44
4.4K
Malika 🧬
Malika 🧬@malikules·
vibecoding my way into permanent underclass
Malika 🧬 tweet media
English
1
0
32
1K
Jake Wintermute 🧬/acc أُعيد تغريده
atlas
atlas@creatine_cycle·
the peptide discourse has been missing this important point
atlas tweet media
English
22
175
4.1K
54.8K
X
X@gulvtomat·
@SynBio1 Have you ever been? You can’t even trust the bottled water in Delhi.
English
1
0
2
57
Jake Wintermute 🧬/acc
It will be interesting to see how this effects the gray market for peptides If I were traveling to India, I’d certainly be tempted to bring home a few vials of $30 generic semaglutide for the homies
Jake Wintermute 🧬/acc tweet media
English
4
0
25
1.5K
Jake Wintermute 🧬/acc أُعيد تغريده
plasmidsaurus
plasmidsaurus@plasmidsaurus·
🦖 You asked. We delivered. The Plasmidsaurus Merch Store is officially OPEN! From Sequence Everything tees to our viral totes, your favorite dino gear is finally ready for the bench (and beyond). To celebrate, we’re launching Merch Madness, a 3-week tournament of challenges where you can win mystery merch by joining in on some friendly competition. Round 1 Challenge: In 5 words or emojis only, tell us: What are you currently sequencing? 🧬👇 Best answer wins mystery merch. 🛒 Plus, grab your favorite gear: merch.plasmidsaurus.com
English
8
6
36
6.9K
Jake Wintermute 🧬/acc
This place is the shitposter insane asylum and anyone who tries to use it for serious purpose will end up sad
Niko McCarty.@NikoMcCarty

Social media has diminishing returns. Sometimes it is better to post less frequently. For example, I increasingly don’t think it is useful to write long-form posts on niche topics, because they attract the same audience repeatedly and take time away from ideas that take longer to write about, but which are probably more impactful over time. I’ve been using Asana to track my tasks for the last ~two years. There are certain tasks I try to do every day, like email a new person, jog for 30 minutes, read a book for one hour, write for three hours, and so on. One of these daily tasks was “Publish a thoughtful social media post.” Many days, I did not do this because I was too busy. But I thought it was a worthwhile goal to have a daily writing prompt, and it often forced me to sit down and read a paper, think about it, and then convey those thoughts through words. I’d share these writeups (many of them long) on X and LinkedIn. Doing this repeatedly was a useful forcing function. And by sharing the things I was learning in public, I often got to meet interesting people. But although this was useful at first — and had big “returns” on things like number of readers — I don’t think repeated social media posts add more value after a certain point, for a few reasons: 1. Learning about and sharing thoughts on papers is not a unique skill. When that Cell Simulation paper came out last week, I spent ~an hour reading it and writing down my thoughts. But anybody can do this! Just upload the paper to a LLM and ask it lots of questions. The fact that so much misinformation spreads about science is *not* because there is a shortage of good technical writers explaining the truth, but rather because most people are too lazy to actually care. People *will* take 15 minutes to do their own research on a topic if it’s important to them. 2. Anybody who publishes daily (or frequently) sees their traffic drop-off at some point. Like, I love Matt Levine’s newsletter, which only comes 3x per week, but I don’t have the time to read every single issue. I read even less of what Derek Lowe and other daily writers have to say. Spacing out your ideas to focus on the “really good ones” seems to have higher returns from readers (and feels more sustainable over time.) 3. Writing a daily article takes time away from writing longer articles. I want to go deep on things, and writing even long posts on social media still isn’t *enough* space to fully flesh out the ideas I care. If people remember me for anything in 100 years’ time (and there’s no guarantee), it certainly will not be for my social media. The only thing I’ve built that might have a decent half-life is Asimov Press, so probably I should launch more big projects like that, rather than dither my days away on Twitter and LinkedIn. This is not a sappy post about me quitting social media, or a political statement, or whatever. I’m still going to post stuff. It’s just I no longer care about posting frequently, and I thought maybe my thought process in arriving at this idea would be helpful to other people as well. (Some of you post much too often!)

English
1
1
21
3.1K