Tom Hellyer

CoReCCT trials are now open to recruitment @DarkNatter @gazkitch @ICS_updates @WarwickCTU @KeithCouper @EPPiC_Warwick @Luigi_ICM @dfmcauley @DanJHadfield @ProfLouiseR @perkins_gd @WUTHresearch

@GoshaWojcik @SHORTERtrial @EdinburghNapier Great opportunity to join the SHORTER team running the process evaluation with @GoshaWojcik .

We're hiring! The NIHR-funded @SHORTERtrial seeks a Senior Research Fellow for the Process Evaluation. A great opportunity for qualitative/mixed-methods researchers to step into a senior role and develop leadership skills @EdinburghNapier Apply now ⬇️ jobs.ac.uk/job/DLA526/sen…

#CCRdownunder24 congress just started 1st study ADAPT-Sepsis published in @JAMA_current Procalcitonin guided protocol ⬇️ antibiotic treatment duration by 1day (significant) but 28-day mortality non-sign⬆️by 7% (relative risk): from 19.4 to 20.9% jamanetwork.com/journals/jama/…

@DrToddLee @ABsteward @BradSpellberg Agree. Implausible. RoB not reported.

@ABsteward @BradSpellberg Implausible

🆕🔥Meta-analysis Impact of Early Antibiotic De-Escalation on Mortality in Febrile Neutropenia in Patients with Hematologic Malignancy Receiving Treatment @BradSpellberg @DrToddLee #IDXposts ashpublications.org/blood/article/…

Published in JAMA with #CCRdownunder: In critically ill adults with suspected sepsis, antibiotic regimens were safely reduced when guided by measurement of procalcitonin but not by C-reactive protein. @CritCareReviews ja.ma/41t10TE

@BradSpellberg x.com/CritCareReview…

Another win for PCT in an RCT.

@James_West_PhD @charlot_summers @PLOSGPH That's terrible and very detrimental to ECR. I'm assoc editor and I similarly get passed on papers that have been in the system for ages with little/no progress. Makes it v difficult if the manuscript needs a lot of work to be ready for publication! Agree, its broken.

I’m one of the academic editors at PLoS One, and I have seen enough of this that I know what likely happened. They are having trouble recruiting and keeping academic editors. To their credit, they have fairly high standards- they mostly want people fairly advanced in their careers. However, it doesn’t come with nearly the prestige of being an editor at a society journal, and so they have trouble getting and retaining people. Nearly 1/3 of the papers I handle these days are transfers from an editor who’s no longer available. I’m thinking of quitting myself, after 10 years, because it’s gotten progressively harder to get reviewers, and the lack of editors means I increasingly handle papers well outside my field. What makes all of this worse is that there are some countries that we receive a lot of papers from, but which I never have any luck recruiting reviewers from. I know we all complain about the breakdown of the current journal system from our end, but I feel like it’s kind of breaking down from the other end as well. Reviewing papers is a community service which people increasingly don’t feel called upon to do.

Update: Today @PLOSGPH sent our manuscript back (after 4.5 months) due to their inability to secure an editor to handle the manuscript or any reviewers. This is despite having previously sent us emails saying the manuscript was under review and a decision would be made soon. 1/2

7d is not a country mile away from standard care in the UK. Recognising microbiological cure is hard. Antibiotics are not without harm. Try @SHORTERtrial @hellyerthomas

Presented at #CCCF2024: In the BALANCE randomized clinical trial, patients with bacteremia were assigned to 7 or 14 days of appropriate antimicrobial therapy, and 7 days of therapy was found to be noninferior to 14 days. Full trial results: nej.md/3Z5bTJD

UK critical care could offer @SHORTERtrial to patients. @hellyerthomas

This is what I gleaned the working group recognised and will seek to address (1) the infeasibility of training in academia and two medical specialities (2) academia now linked to pay penalties through slower progression and diminished merit awards….

More posters today from trial managers Gillian Watson and @AGrSwain Come and find out more about recruitment during COVID-19 and lessons in running dental trial @enhanced_trial #ICTMC2024

Come and see @Dean_Allerton to learn more about #eConsent in the @IBDResponse study #ICTMC2024

7 days in the week. 5 digits on your hand. So naturally antibiotic courses are multiples of 7 or 5 🤔. @SHORTERtrial large @NIHRresearch funded trial investigating short (5 day) course of antibiotics vs SoC in sepsis. Challenging the 'week's course' dogma.

New data released today in @TheLancet shows that without urgent action, antimicrobial resistance could kill 39 million people by 2050. Deaths and inequities from the global antibiotic emergency are increasing and now is the time to take urgent action. thelancet.com/journals/lance…

💥💥💥MAIN RESULTS💥💥💥 The PEACH team are delighted to finally share the main results of this study! @CarrolEnitan @j_sandoe @emma_tj1 @Dr_JoanneEuden @LBrookesHowell @DetelinaGrozeva @CTRCardiffUni @UniversityLeeds and many others. academic.oup.com/jac/advance-ar…

NHIP Academy was delighted to support eight exceptional researchers throughout their application process to be successfully awarded the new Senior Clinical and Practitioner Research Award (SCPRA) from the @NIHRresearch (NIHR). Read the full story here: newcastlehealthinnovation.org/news/research-…

There is a crisis in clinical academia in the UK. We talk of the need to expand medical schools, embed research into the NHS to improve care, & the importance of a vibrant life sciences sector for the economy of the UK, & yet we seem unable to tackle the underlying issues 1/9

Amazing effort by the @SHORTERtrial sites and by the @NclCTU team to get off to such a good start. Keep on going!