Roy Scott

@thealikazai @SethSHowes Then you should read more

@SethSHowes Most interesting read iv read in a while. Thanks.

I sequenced my genome at home, on my kitchen table. I wrote up exactly how I did it - the equipment, protocol, theory, and cost: iwantosequencemygenomeathome.com

@SpityGonzalez @SethSHowes This was such a juvenile description you just pointed out. JFC, there are waaaay too many people demonstrating Dunning-Kruger effect due to AI use

@logicwins @SethSHowes That’s sad. You really aren’t finding much to read

@SethSHowes This is the coolest article ive read on X in a long time. Thanks for posting it

@realarmaansidhu @SethSHowes 🤮 write your own comments you fucking loser

Someone just sequenced their own genome on their kitchen table. This would have cost $3 billion and required specialized facilities in 2003. It can now happen at home. This is biotech democratization that most industry commentary misses. Here's what actually changed to make this possible. Oxford Nanopore released MinION portable sequencers. Device costs approximately $1,000. Consumables per sequencing run cost $500-1000. Complete home genome sequencing runs approximately $2,000-3,000 total. Compare to historical benchmarks. First human genome: $3 billion. First commercial genome sequencing: $10 million in 2007. Commercial sequencing 2015: $5,000. Home sequencing 2026: $2,000. The cost curve has followed Moore's law-adjacent trajectory across 25 years. For biotech industry specifically, the implications matter substantially. Illumina dominates commercial sequencing with premium-priced instruments and consumables. Oxford Nanopore provides lower-cost alternatives that enable home and field sequencing. The competitive dynamic favors democratization. Lower-cost alternatives capture specific market segments Illumina can't efficiently serve. Commercial sequencing services (23andMe, Ancestry, specific medical sequencing) face long-term pressure as home sequencing becomes viable for technically inclined users. For DIY biology movement, this represents specific capability advance. Biohacking community has been building toward accessible biotech for years. Home PCR, basic genetic engineering, specific diagnostic capabilities have been developing. Genome sequencing at home represents specific milestone. Previous limitations on scale and equipment have been overcome. This doesn't democratize all biotech. It democratizes specific capabilities. For medical implications, specific considerations matter. Home sequencing produces data without clinical interpretation infrastructure. Specific medical decisions require professional analysis regardless of sequencing source. Insurance coverage, medical record integration, and specific regulatory frameworks don't accommodate home-sequenced data smoothly. The capability exists. The healthcare integration lags substantially. For privacy implications, home sequencing has specific advantages. Commercial sequencing services have been associated with specific privacy concerns. Data sharing with pharmaceutical companies. Law enforcement requests. Specific breach events. Home sequencing keeps data local by default. Privacy protection depends on user choices rather than corporate policies. For individuals with specific privacy concerns, home sequencing offers advantage commercial services can't match. For research implications, democratized sequencing creates specific opportunities. Citizen science projects can access sequencing capability previously restricted to institutional research. Specific research questions become accessible to non-institutional researchers. Community-level genomic monitoring becomes possible. Specific disease tracking, environmental monitoring, and local research projects can proceed with community funding rather than institutional grants. For the specific individual who sequenced their genome at home, practical value depends on specific context. Personal curiosity: substantial satisfaction from scientific self-knowledge. Medical purpose: limited value without professional interpretation infrastructure. Technical learning: substantial educational value in the process itself. Privacy protection: specific advantage over commercial alternatives. Different motivations produce different actual value. For investors watching biotech industry, specific dynamics matter. Companies positioned for democratization (Oxford Nanopore, specific consumables manufacturers) benefit from expanding accessible market. Companies dependent on premium-priced institutional sales (specific traditional sequencing providers) face structural pressure. Services companies (interpretation, consultation, specific clinical integration) may benefit as democratization expands data availability. The industry structure evolves. Specific winners and losers emerge from democratization. For consumers, home sequencing represents specific option with specific tradeoffs. Cost: $2,000-3,000 plus time investment to execute correctly. Privacy: substantial advantage over commercial services. Capability: comparable to commercial sequencing for basic applications. Limitation: no professional interpretation included. If these tradeoffs align with your priorities, the option now exists. For the broader technology pattern, home sequencing represents specific democratization instance. Previous decades democratized computing, publishing, manufacturing, broadcasting, financial services. Biotech democratization follows similar trajectory with specific biological industry characteristics. The pattern suggests continued capability expansion to individual level across traditionally institutional domains. For specific applications in your own situation, consider whether home sequencing serves your specific purposes. Most people don't need genome sequencing for immediate practical purposes. Those who do have specific medical, research, or curiosity motivations now have accessible option. The accessibility matters regardless of whether most people use it. Specific populations with specific needs benefit from the democratized capability. Seth Howes's kitchen table genome sequencing is specific example of broader democratization pattern. Appreciate the technical achievement. Recognize the broader implications. Biotech capability is expanding beyond institutional control. This matters for industry economics, medical practice, privacy protection, and individual capability. Apply the framework to your evaluation of biotech industry and your personal health decisions accordingly.

@hullalulu @Throrf @SethSHowes Yet here you are, along with OP, posting in a social media platform gobbling up your data for free to corporations. 🤣🤣🤣🤣🤣

@Throrf @SethSHowes wasn't the whole point of it not giving his data away to corporations?

@SethSHowes … but why? You can pay many companies to do this for dramatically less money, because they do it at scale. This is silly

@rashiumapathi @coreyganim It’s only sellable if you find some fucking dumb enough to pay for it 🤣🤣

@coreyganim Simple, clear, and actually sellable. Most people overcomplicate this instead of packaging it like this.

what you're looking at is a $999 service with a $10K back end attached: 1. 45-min Zoom. Ask where their time goes. Fathom records it. 2. Feed the transcript to Claude. 5-7 tool recommendations in minutes. 3. Build the report in Gamma. 30-min walkthrough call to deliver. 4. 60% of clients want implementation. That's where the real money is. 5. Expansion menu: $1-3K automations, $3-5K redesigns, $5-10K full builds. 4 audits a month = $48K/year. Before a single upsell. Full playbook in the image.

@Barrettsharpe @coreyganim 🤣🤣🤣 this post was written by AI and all of you are full of shit

The math on this should make anyone who's still thinking about "starting a business" stop and pay attention. A 45-minute Zoom call. You're not pitching. You're just asking one question: where does your time actually go? Fathom captures every word. You don't take a single note. Claude turns the transcript into 5-7 specific recommendations in minutes. Not generic advice. Real things, pulled from their actual words about their actual day. Gamma makes the deliverable look like it came from a firm that charges ten times what you do. Total time: maybe two hours. Maybe less once you've done a few. And here's what happens on the other side of that call. The client is sitting there staring at a professional report that just mapped their entire operation and pointed to every place they're quietly losing time and money. Nobody has ever done this for them. Not their accountant. Not their "business coach." Not the software vendor who promised it would be easy. You just showed them something about their own business they couldn't see because they were too deep inside it. That's not a deliverable. That's a mirror. And when someone sees themselves clearly for the first time, sees the chaos they've been living in and calling normal, they don't need to be convinced. They ask you how fast you can fix it. The $999 is the handshake. The $10K back end is what happens when trust gets built in two hours instead of two months.

@coreyganim @Brave_Trades Where do you find people dumb enough to pay you this? 🤣

@Brave_Trades the discovery call is part of the audit which is $999

@CtrlAltDwayne @revsolana Correct and most “vibe coders” do not have the skills to succeed in developing software using AI heavily. Hell, I’d argue most software developers don’t have the right skills with leveraging AI for it to be a net benefit. The AI hype is very real

@revsolana LMAO yeah literally in this instance.

The vibecoders are starting to give up because they're learning AI can't do everything for you. They're tools that are powerful in the hands of people who can code, but vibecoders are not real devs.

@DeRonin_ It’s obvious you are combining “engagement bait” in your title with lazy SEO optimization with your CLEARLY AI generated slop of an article. Nothing in it is enlightening and any self exploration via simply prompting to self learn in this space would lead to all aspects covered

@0xDepressionn @DeRonin_ … he’s using AI to generate it all you fucking dumbass 🤣🤣🤣

@DeRonin_ bro, how you dropping banger everyday? and still inviting me for play games do you have 30 hours per day??

@dudu_bitcoin @DeRonin_ 🤣🤣🤣🤣🤣🤣🤣🤣

@DeRonin_ Setting this up as an MD file for my agent thanks!

@DaniREscudero @DeRonin_ True and OP is a fucking moron who has no software experience. These are the idiots to avoid in the tech field right now. They just cause tons of problems by pushing tons of shit code they don’t understand

@DeRonin_ Programmers are dead, AI took over. Nah! Checking your steps, it's clear that AI is just a tool on steroids for a programmer. You still need to have a developer mindset, something lacking among people. So, if you're a programmer your're still save, you just need to update.

@DeRonin_ @rmnmllr This is proof you are a fucking idiot, man. At 19 you don’t know jack shit about actual software development. You just trust the AI outputs

@rmnmllr ahahah, indeed lol

@rmnmllr @DeRonin_ … lol. No. They think they can but I guarantee you most of you dipshits don’t have a fucking clue, because you just keep reprinting until your next problem feels “solved”. It’s truly pathetic

@DeRonin_ I think everyone with a Brain (or without) is able to Code now😂

@Lunar_Aisle @DeRonin_ @bandosei Sure! He wants you to believe so. He doesn’t know much either, because almost all of this was Ai generated anyway. Fake it till you make it seems to be their strategy. 🤣 I enjoy watching my junior devs flail about with AI implementations for a while before we can them

@DeRonin_ @bandosei I have no tech skills... Can't code .. can I still embark on this?

@DeRonin_ @bandosei 🤣🤣🤣 you are such a tool, dude. In the digital age, nobody is reading your AI generated, 10,000 word slop

@bandosei I am pretty sure that everybody will read it!!!

@kip_dynamite_69 @DeRonin_ @hooeem You mean they are testing actual technical and intellectual skills? Oh the absolute HORROR! AI should have taught you all you need to know and more! I mean, otherwise you are just trusting the AI outputs are correct because you don’t know jack shit

@DeRonin_ @hooeem Only problem is other companies need to catch up. I e been getting interviews trying test old school skills that have atrophied away.

@ai_with_junaid @DeRonin_ @hooeem Lmfao. No. You aren’t suddenly getting a major job by following a sloppy AI generated list of things that you cannot possibly even feel you’ve scratched the surface of within 6 months

@DeRonin_ @hooeem After covering these, can someone be hired at faang ?