Simon Hill MSc, BSc

8 years and 400+ episodes hosting The Proof podcast Here’s 10 episodes I recommend listening to if you’re interested in improving your health.

@Kansanparantaja @SBakerMD PS love the anonymous profile you’re hiding behind 😂

@theproof @SBakerMD And even later Cochrane data mainly show reductions in composite CVD events, with little or no effect on all-cause mortality, CVD mortality, or non-fatal MI. That is a much narrower claim than your reply suggests. cochranelibrary.com/cdsr/doi/10.10…

Lp(a) is now considered a very important driver of cardiovascular disease. We are told it is genetic and that a “healthy diet” can’t affect it! However several studies, including this randomized controlled trial, show that decreasing carbs and increasing saturated fat can in fact drive down Lp(a) sciencedirect.com/science/articl…

@Kansanparantaja @SBakerMD Now with that said, what evidence exists to support LP(a) reduction with diet (which likely increases ApoB) has a meaningful effect on events. Not asking for mortality. Just events.

Expecting clinical trials that go for approx 2 years on average to show a diff in total mortality is misguided. From Lee Hoopers Cochrane report “Quality of the evidence There is a large body of evidence assessing effects of reducing saturated fat for at least two years. These studies provide moderate‐quality evidence that reducing saturated fat reduces our risk of cardiovascular disease”

@Kansanparantaja @SBakerMD I said “what evidence?” Nonetheless summary of clinical trials and observational in the below paper from Frank Sacks et al. ahajournals.org/doi/10.1161/CI…

@theproof @SBakerMD Could you cite a study that directly observed those reduced event rates under controlled conditions, rather than inferring them from large prospective cohort data with the usual residual confounding and model-dependence? That was exactly the standard you seemed to want from Shawn

@withered_haze @Skotakollar @VinnieTortorich Who’s that?

@Skotakollar @theproof @VinnieTortorich Lmao linking Bart Kay in 2026.

The Best evidence? Sure, walk outside and look around...

@DrIngold @SBakerMD For a guy that seems quite intelligent he sure seems to leave out a lot of important context when talking about Nutrition.

Lp(a) being lowered, even by medications, hasn’t proven to reduce CVD events. The same high SFA diet which could lower Lp(a) concentration by ~5.5% would also statistically increase ApoB by 5-10% (the same ApoB Shawn quite clearly stated is causal of ASCVD when he was talking with Dr. Cromwell) Either @SBakerMD didn’t know this (and therefore everyone should know he’s not quite knowledgeable on this subject) or he knows this and deliberately withheld that information from his audience (which should disqualify him from speaking on the subject).

@Kansanparantaja @SBakerMD I think it’s important context to state. On the flipside we do have evidence that reducing saturated fats lowest risk of events when replaced for polyunsaturated fats, monounsaturated fats and or whole grains.

@theproof @SBakerMD That is not what Shawn actually claimed. He claimed the diet changed Lp(a), not that the observed reduction was proven to be clinically meaningful. Those are two different questions.

Best comment of the week IYKYK

NEW JAMA cardiology paper - PROMISE randomised clinical trial looking at plaque volume and major cardiovascular events. jamanetwork.com/journals/jamac… H/T Dr Dan Soffer.

@theproof @VinnieTortorich This is the type of response when the actual evidence is contrary to their desired belief.

@withered_haze @VinnieTortorich So I can create a story depending on what I choose to see outside?

@theproof @VinnieTortorich *looks outside* *highest ever life expectancy* God dayum those seed oils be mighty powerful

@NutritionMadeS3 Thanks @NutritionMadeS3

Great contribution setting this up Simon!

@VinnieTortorich Can you provide the best evidence you have that seed oils are inherently unhealthy? Love to see it.

This is the part where we will disagree... Eggs are one of the healthiest foods you can put in your mouth. I can show you a couple of studies, but that won't matter, because you will come back at me with something from Dr Greger (never finished his degree) saying that even one egg per week will clog arteries. Or, maybe Dr Alo who likes to make it up as he goes. Maybe a Harvard study, but Willet sold out a long time ago. Eating a whole plant diet is not the worst thing you can do... You will be lacking in a few amino acids along with vitamins, but doable. Eating a vegan diet full of sugars and grains is where the real problem comes in. I don't have a horse in this race, I just want people to be healthy. Processed foods (Which we agree, are not healthy) full of processed sugar, grains and seed oils are the problem.

@DeathlyHarvest @TyBealPhD Is it an assumption? Or a fact?

@theproof @TyBealPhD I already know. He's a fraud.

The new U.S. Dietary Guidelines sparked a huge debate in nutrition. Christopher Gardner, Ty Beal, and I unpack what the science actually says about ultra-processed foods, protein, and where most people are getting nutrition wrong. For the full show notes head to: theproof.com/the-dietary-gu…

@DeathlyHarvest @TyBealPhD can answer that!

@theproof Who funds ty Beal? beef and dairy?

@paulsaladinomd ??

In our latest study we show that resistance-bands work 💪 These are a great alternative to use when you are travelling, can’t get to the gym, tight on time, etc. Resistance-bands + creatine (3 or 5 grams/day) work a bit better 😊 #creatine sciencedirect.com/science/articl…