Agard Lab retweetet
Smriti Sangwan (@smriti_sangwan) from the @agardlab & Peter Walter labs @UCSF is about to present her research - molecular mechanisms of translational regulation.
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Agard Lab
35 posts
Agard Lab
@AgardLab
Structural Biology/Biochemistry Lab @UCSF #cryoEM Tweets by lab members
San Francisco, CA Beigetreten Ekim 2020
71 Folgt802 Follower
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Nature Communications@NatureComms
New featured image on our homepage! nature.com/ncomms/ Related to this article: The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice nature.com/articles/s4146… @ENieweglowska @AgardLab @UCSF #phagenucleus #jumbophage #phage #structuralbiology
ART
Congratulations to Maru & team on the lab’s latest pub!
PP5 requires the molecular chaperone Hsp90 to dephosphorylate CRaf kinase and Hsp90 cochaperone Cdc37. Here, authors show how Hsp90 acts as a platform to allow for targeted dephosphorylation by PP5.
nature.com/articles/s4146…
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Check out the latest preprint from @andreafossati9 and @MozumdarDeepto on using SEC-MS to identify protein:protein interactions during jumbo phage infections! Congrats, team!
#phage #jumbophage #secms
Andrea Fossati@anfossati
New preprint alert! Here we show how SEC-MS is a powerful tool for host pathogen interactions profiling. We applied it to Jumbophages, which are large bacterial viruses (>300 genes) holding great potential as antibiotics. What did we find? 1\n biorxiv.org/content/10.110…
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Please check out our latest publication from grad student @ENieweglowska on the self-assembly of the phiPA3 phage nucleus! Congrats to the whole team! @MmendezMoran @minkbaek @UWproteindesign @yifan_ucsf @joeBondyDenomy
Eliza Nieweglowska@ENieweglowska
Excited to share the, now published, final version of my grad school research! Here are a few PhuN highlights from the full story. 🧵 #phage #jumbophage #cryoem #Sec25" target="_blank" rel="nofollow noopener">nature.com/articles/s4146…
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Check out our latest preprint! #CryoEM structures of immunophilins, FKBP51 and FKBP52, in complex with Hsp90 and the glucocorticoid receptor, demonstrating the FKBP co-chaperones directly bind an Hsp90 client to regulate client activity. From recent grad @ChariMN w/ Jill Johnson
bioRxiv@biorxivpreprint
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the Glucocorticoid Receptor biorxiv.org/cgi/content/sh… #bioRxiv
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Agard Lab retweetet
@AgardLab shared amazing data (published/unpublished) on Hsp90 chaperone complexes. @Hsp90Machine
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High resolution cellular cryoET!
Zhen Chen@ZhenChentccz
We optmized in situ cryoET to achieve 6 A reconstructions of mouse sperm doublets! The unique tertiary structures allow de novo protein identification of novel sperm proteins by computationally searching in the AlphaFold2 library of entire mouse proteome! biorxiv.org/content/10.110…
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Agard Lab retweetet
A family of novel immune systems targets early infection of nucleus-forming jumbo phages biorxiv.org/cgi/content/sh… #biorxiv_micrbio
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Agard Lab retweetet
this just in --- our FTD CWOW website is LIVE! cwow.ucsf.edu Time to spread the news! Great work from our team @Karen_Shuster, @aimee_kao @YokoyamaLabUCSF @karchlab @AgardLab @metadsr_ @tauCWOW #ftdcwow
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Agard Lab retweetet
We’re excited to announce that David Agard, Bridget Carragher + Clint Potter have joined our new @ChanZuckerberg Imaging Institute to bring together scientists and engineers to develop new cryoelectron microscopy imaging hardware and software
🧵czi.co/ImagingInstitu…
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Check out our latest pre-print from postdoc Zhen Chen @ZhenChentccz on mammalian sperm axonemes revealed by in situ cryoET!
Zhen Chen@ZhenChentccz
Our preprint on asymmetric axonemes of mammalian sperm revealed by FIB-SEM/cryoET: biorxiv.org/content/10.110… Thanks for the support from the Vale lab and Agard lab! This work would not be possible without my amazing collaborators from the Lishko lab and Janelia Research Campus.
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Agard Lab retweetet
Explore emerging research and network with peers at our Protein Folding in the Cell Conference. Organized by Manajit Hayer-Hartl @MPI_Biochem and Jeffery Kelly @scrippsresearch. Don't miss keynote speaker David A. Agard @AgardLab bit.ly/3NGsdc3 #PFCSRC22
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Agard Lab retweetet
The {varphi}PA3 Phage Nucleus is Enclosed by a Self-Assembling, 2D Crystalline Lattice biorxiv.org/cgi/content/sh… #bioRxiv
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Congratulations to all of our authors! @ENieweglowska, Axel Brilot, @MmendezMoran, @minkbaek, Junrui Li, Claire Kokontis, David Baker (@UWproteindesign), @yifan_ucsf, and @joeBondyDenomy
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Check out our latest preprint showing that the major protein enclosing the Phage Nucleus (PhuN) forms a tetrameric lattice with C2 symmetry. The symmetry establishes 4 unique interfaces, two large enough to act as channels for small molecules, RNA, or even unfolded proteins.
Eliza Nieweglowska@ENieweglowska
Excited to share our findings about the self-assembly of the phage nucleus! In short: it’s primarily composed of a single ~70 kDa protein and forms a beautiful (I may be a little biased 😍) C2 symmetric lattice! biorxiv.org/content/10.110…
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Agard Lab retweetet
We've got that Friday feeling! Earlier this week, #tau2022 was a success! Our #ftdcwow team was in attendance and thrilled to discuss about Tau. @karchlab @YokoyamaLabUCSF @AimeeKaoLab @AgardLab @metadsr_ alz.org/tau/overview.a…
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Agard Lab retweetet
#CryoeM #CryoET has enormous potential allow researchers to study #structuralbiology in situ but low throughput limits applications. This new publication from Shawn Zheng of @AgardLab @UCSF addresses that problem and offers on-the-fly processing!
biorxiv.org/content/10.110…
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