Celeste Karch

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies: Stem Cell Reports cell.com/stem-cell-repo…

Excited to share our preprint showing cGAS mediates innate immune activity in TDP-43 proteinopathy. Pharmacological inhibition of cGAS restores microglial function, corrects RNA mis-splicing, & protects motor neurons across human iPSC & mouse models of ALS biorxiv.org/content/10.648…

New work from our lab reveals that the microenvironment around amyloid is not uniform in AD/CAA. Using spatial transcriptomics, we show that vascular vs parenchymal Aβ deposits drive distinct molecular responses. @BCMFromtheLabs @bcmneurology @EChimalJ alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

@DrNeuroChic Congratulations 🎉

We are over the moon with excitement and humbled to be 2026 Rainwater Prize winners. To be awarded alongside my former mentor, long time collaborator, and truly great human @dennis_w_dicksin is such an honor.

A milestone moment for science in #Nigeria Nearly 15 years ago, when I first came to England for my MSc, I developed a conviction, that the kind of scientific ecosystem I was experiencing should also exist at home. Although I now call both the UK and Nigeria home, on Thursday, 29 January 2026, that long-held idea became a full reality with the commissioning of the @BioRTCNig by His Excellency, Hon. (Dr.) Mai Mala Buni, Executive Governor of Yobe State. BioRTC formally began in 2021, with support from the #Yobe State Government and @TReNDinAfrica, and in collaboration with Yobe State University, which initially provided a modest laboratory space within the Department of Physiology. As research expanded, equipment arrived, and global collaborations grew, His Excellency approved our relocation to a larger interim site and directed the construction of a purpose-built permanent facility, ensuring continuity, scale, and long-term impact. The permanent BioRTC facility was constructed and furnished by the Yobe State Government — a rare and courageous investment by a sitting Governor in advanced biomedical science. Today, BioRTC: - houses ₦10+ billion in advanced research infrastructure - leads nationally significant research on kidney disease, malaria, and dementia - trains scientists from Yobe State, Nigeria, and across Africa - hosts international experts from around the world What made this moment especially powerful was the presence of the Governor, senior government officials from State and Federal Governments, traditional institutions, international scientists, academics, and members of the public — all affirming one clear message: science belongs here. I am deeply grateful to His Excellency and the Government of Yobe State, to Yobe State University, our global partners, the people of Yobe State, and to my family, whose quiet support sustained this journey. BioRTC is no longer an idea. It is now an institution, and with continued stewardship, it will be a legacy for generations.

AD genetic risk links microglial immunity & cholesterol. Our new BioRxiv study identifies CH25H-derived 25-HC as a toxic lipid downstream of cGAS–STING–IFN that drives tau spread, inflammation, & neurodegeneration, offering a tractable therapeutic pathway biorxiv.org/cgi/content/sh…

Postmortem brain reveals that aducanumab had cleared plaques and lessened tau pathology but increased vascular amyloid. #alzheimersdisease @MassGeneralNews ow.ly/OOjF50XM8G5

FTD can be confusing, especially when someone who's been diagnosed is a parent, grandparent, or close friend. That’s why explaining FTD to kids & teens matters. Slide through to see a simple way to explain FTD and help them understand: what it is, what changes might look like, and how they can still share love and connection. 👉 Explore more: bit.ly/48TnAaf

Lysophosphatidylcholines are associated with amyloidosis in early stages of Alzheimer’s disease: nature.com/articles/s4358…

Excited to share our new work on immune aging! We explored whether the liver could serve as a temporary "factory" to produce immune factors that decline with aging, potentially helping to rejuvenate aged immunity. @mircoscopy.

GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis | Science Advances science.org/doi/10.1126/sc…

New study in Neuron: ApoE2 & ApoE3 Christchurch-containing lipid particles protect neurons from ferroptosis by effluxing oxidized lipids through ABCA7. This rescues lysosomal defects, shields ApoE4 hippocampi from lipid toxicity, & restores neural activity cell.com/neuron/abstrac…

An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier hubs.li/Q03SM0jQ0 Article highlight from Cell Stem Cell

A major new study from the lab showed how blood proteomics could transform Alzheimer’s disease and other forms of dementia diagnosis. We analyzed blood samples from more than 3,200 participants from the @WashUMedADRC including #Alzheimer, #Parkison, DLB and FTD @WashUNeurology

Human microglia differentially respond to β‐amyloid, tau, and combined Alzheimer's disease pathologies in vivo alz-journals.onlinelibrary.wiley.com/doi/10.1002/al… @alzdemjournals

New PhD position with us and @EastbioDTP is now open, focused on developing novel iPSC- organoid models 👇👇👇 findaphd.com/phds/project/e…

Our new paper by Melvin King @MKing629 is out! GABAergic Bmal1 KO reduces amyloid plaques and p-tau in 5xFAD mice- but only in LD! In DD, 5xFAD mice have fewer plaques and GABergic Bmal1 KO has no effect. Suggests light-clock interaction controls Abeta. alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Our new Neurology Genetics paper shares preliminary evidence that ATXN10 motif architecture, not just expansion length, may influence onset in SCA10. This is the first step. More sequencing, larger cohorts, and deeper analyses are coming. neurology.org/doi/pdf/10.121…

Frost lab paper alert! This study was led by @PaulRamirez42, Lead Biostatistician for the @BrownUniversity Center for Alzheimer’s Disease Research: alz-journals.onlinelibrary.wiley.com/doi/epdf/10.10…

Study shines light on the “dark genome” of Alzheimer’s. Long-read sequencing uncovered retrotransposon activity near risk genes and methylation shifts in repetitive DNA, revealing new genetic instability in AD. @BrownUniversity ow.ly/nhu550Xs2GW

We are pleased to share our newest publication from the @BlurtonJonesLab, "CSF1R inhibitor-resistant model for CNS-wide microglia replacement strategies" sciencedirect.com/science/articl…