Celeste Karch

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies: Stem Cell Reports cell.com/stem-cell-repo…

@FumihikoUrano Congratulations!!

After 20 years of work, our team achieved the first positive clinical trial data in the history of Wolfram syndrome research worldwide. Deeply grateful to our team, patients, families, and collaborators. jci.org/articles/view/…

Studying these young Alzheimer's patients led to breakthroughs, but the funding was cut. npr.org/2026/05/07/nx-…

We are excited to announce that Dr. Ana Maria Cuervo @AMCuervoLab will be our next ISMND webinar speaker! Selective #autophagy: fighting #neurodegeneration one protein at a time May 14, 2026 10-11am (ET) Host: Dr. Hui Zheng Registration: bit.ly/4tXtGzN

🚨 New in Sci Transl Med! science.org/doi/10.1126/sc… Our cross‑fluid proteogenomic study shows <30% of pQTLs are shared between CSF and plasma, revealing why plasma misses key biology. We identify 427 protein–trait (249 new) links. Context matters for target discovery. 🧠🔬

New collaborative study in Nature Medicine! Our AcTau174 antibody powers a sensitive CSF assay from Teunissen lab that cleanly separates FTLD-TDP from FTLD-Tau & tracks cognitive decline in AD & FTLD—enabling subtype-specific clinical trial enrollment nature.com/articles/s4159…

Excited to share new work led by Sam Swift in the lab identifying NINL as a modifier of tau seeding alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Chemical compound clears cellular waste, protects neurons in model of frontotemporal dementia source.washu.edu/2026/03/chemic…

Traditional single cell transcriptomics doesn't capture most non-coding RNAs. In this work, led by @alinaisakovaSci and @StephenQuake, we introduce TotalX, a @10xGenomics-compatible pipeline that captures both coding and non-coding transcripts. Out now in @NatureBiotech! 1/7

@mathieubourdenx We immediately thought of your great study in the Cuervo lab. We haven’t looked at many other antibodies like the acTau but we should!

@karchlab Wonderful work @karchlab! The localisation of pTau at the lysosome membrane is very interesting. Did you look for acTau? This reminds me of what we observed for CMA and acTau in doi.org/10.1038/s41467…

Pleased to share our latest study using super resolution to show that a pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia by the amazing Dr Mirfakhar 🔬🧫 nature.com/articles/s4146…

New research from WashU Medicine adds to growing evidence that helping brain cells break down and eliminate their own cellular waste is a promising treatment strategy for a variety of neurodegenerative diseases. medicine.washu.edu/news/chemical-…

Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition. cell.com/neuron/fulltex…

Excited to share our preprint showing cGAS mediates innate immune activity in TDP-43 proteinopathy. Pharmacological inhibition of cGAS restores microglial function, corrects RNA mis-splicing, & protects motor neurons across human iPSC & mouse models of ALS biorxiv.org/content/10.648…

New work from our lab reveals that the microenvironment around amyloid is not uniform in AD/CAA. Using spatial transcriptomics, we show that vascular vs parenchymal Aβ deposits drive distinct molecular responses. @BCMFromtheLabs @bcmneurology @EChimalJ alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

@DrNeuroChic Congratulations 🎉

We are over the moon with excitement and humbled to be 2026 Rainwater Prize winners. To be awarded alongside my former mentor, long time collaborator, and truly great human @dennis_w_dicksin is such an honor.

A milestone moment for science in #Nigeria Nearly 15 years ago, when I first came to England for my MSc, I developed a conviction, that the kind of scientific ecosystem I was experiencing should also exist at home. Although I now call both the UK and Nigeria home, on Thursday, 29 January 2026, that long-held idea became a full reality with the commissioning of the @BioRTCNig by His Excellency, Hon. (Dr.) Mai Mala Buni, Executive Governor of Yobe State. BioRTC formally began in 2021, with support from the #Yobe State Government and @TReNDinAfrica, and in collaboration with Yobe State University, which initially provided a modest laboratory space within the Department of Physiology. As research expanded, equipment arrived, and global collaborations grew, His Excellency approved our relocation to a larger interim site and directed the construction of a purpose-built permanent facility, ensuring continuity, scale, and long-term impact. The permanent BioRTC facility was constructed and furnished by the Yobe State Government — a rare and courageous investment by a sitting Governor in advanced biomedical science. Today, BioRTC: - houses ₦10+ billion in advanced research infrastructure - leads nationally significant research on kidney disease, malaria, and dementia - trains scientists from Yobe State, Nigeria, and across Africa - hosts international experts from around the world What made this moment especially powerful was the presence of the Governor, senior government officials from State and Federal Governments, traditional institutions, international scientists, academics, and members of the public — all affirming one clear message: science belongs here. I am deeply grateful to His Excellency and the Government of Yobe State, to Yobe State University, our global partners, the people of Yobe State, and to my family, whose quiet support sustained this journey. BioRTC is no longer an idea. It is now an institution, and with continued stewardship, it will be a legacy for generations.

AD genetic risk links microglial immunity & cholesterol. Our new BioRxiv study identifies CH25H-derived 25-HC as a toxic lipid downstream of cGAS–STING–IFN that drives tau spread, inflammation, & neurodegeneration, offering a tractable therapeutic pathway biorxiv.org/cgi/content/sh…

Postmortem brain reveals that aducanumab had cleared plaques and lessened tau pathology but increased vascular amyloid. #alzheimersdisease @MassGeneralNews ow.ly/OOjF50XM8G5

FTD can be confusing, especially when someone who's been diagnosed is a parent, grandparent, or close friend. That’s why explaining FTD to kids & teens matters. Slide through to see a simple way to explain FTD and help them understand: what it is, what changes might look like, and how they can still share love and connection. 👉 Explore more: bit.ly/48TnAaf

Lysophosphatidylcholines are associated with amyloidosis in early stages of Alzheimer’s disease: nature.com/articles/s4358…