MucinGlycoLab_UBC

Fantastic new study from the Vereecke Lab!

#ThrowbackThursdayScience. 1992. Insightful work from influential pioneers in mucus biology, Anthony P. Corfield and Lansing C. Hoskins, revealing the tremendous digestive capabilities of the microbiota and its relationship to mucus. We know now that mucus--via it's O-glycan forest-- is a workhorse that simultaneously feeds our microbiota through its niche functions, and shields our tissues from the microbiota (and its digestive enzymes) through its barrier functions – constantly protecting our bodies from infection and chronic intestinal diseases like #IBD and #ColonCancer. #thankfulformucus gastrojournal.org/article/0016-5…

Fantastic innovative work from the Malaker Lab!

#ThrowbackThursdayScience 2002. The lab of Richard Cummings identifies Cosmc, a crucial chaperone required by mammalian core 1 beta 1,3 galactosyltransferase to synthesize core 1 and all complex O-glycans emanating from this structure (Ju & Cummings, PNAS, 2002). Not only that, but the Cosmc gene (C1GALTC1) was found to be X-linked! The importance of this study for our understanding of O-GalNAc glycan biosynthesis, mucus function, and IBD, cannot be understated and impacts our work today. #glycotime #mucins #mucus @SFGlycobiology pubmed.ncbi.nlm.nih.gov/12464682/

Unexpected antibiotic-mucus relationships reported from the Bel Lab with implications for IBD!

👏Hot off the press! The biofunction of #Akkermansiamuciniphila in intestinal-related diseases oaepublish.com/articles/mrr.2… 🤲This review provides an overview of the research history and understanding of A. muciniphila and its association with various intestinal-related diseases.

@HayleySGorman Thanks Haley! For science, not that I've seen...but I certainly think is good for science to remember the foundations laid by past researchers, how far we have come (or not come!), and perhaps remember what inspired us to pursue this crazy career!

@BergstromLabUBC Is throwback Thursday a thing in science, or am I just really behind? LOVE THIS IDEA

Throwback_Thursday: 2005. This beautiful study came out that demonstrated the flexibility of Bacteroides thetaiotaomicron to switch between utilizing dietary and mucin glycans depending on the dietary fiber load. Fascinating to think about what is going on inside B. theta as it senses its glycan microenvironment. Highly influential to me as a young graduate student. #glycotime #mucins #mucusmatters @LabSonnenburg

Fantastic review from the Mahal Lab! @glycocode

🚨🚨News from MucinGlycoLab🚨🚨 - New insights into how the intestinal epithelial sialome protects from spontanous colitis, mucositis, and tumor development: We uncover unexpected roles of sialylation in impacting b1 mucus functions, the microbiota, and the stem cell niche! #mucin #glycotime @getgutsycanada @HlthResearchBC Amazing journey with my fantastic team @ubcokanagan and with Oklahoma collaborators @OMRF, including my longtime friend and fellow mucinglyco-research warrior Xindi (Dylan) Shan @DylanShanxindi 🪖🪖 Uncorrected Proof: cmghjournal.org/article/S2352-…

Fascinating and important body of work from the Birchenough Lab @GobletCellGuy @MucinBiology studying goblet cell-mucus-microbiota relationships in neonatal mice! A must-read!

Another innovative study from the talented Allbritton Lab @UWBioE – this time using a novel in-vitro model of fecal-coated mucus to stimulate MUC2 and cytokine secretion from colonic epithelium! #mucin#UWBioE pubmed.ncbi.nlm.nih.gov/38677221/

@sweetmicrobe @BrumerLab @kristin_low @tingley_jeff @GretaReintjes Congratulations!! Look forward to using this amazing tool!

SACCHARIS v2 is out! 🍬💻More user friendly features and applications for predicting carbohydrate enzyme function! Wonderful collaboration with @BrumerLab! Part of the new Protein Bioinformatics MIMB book. link.springer.com/protocol/10.10… @kristin_low @tingley_jeff @GretaReintjes

@Mucus_Man @micromindy @GobletCellGuy @MariaNaama_ @tel_paz Fecal-adherent mucus - the glycan-rich host-microbe mobile interface tirelessly at work to protect our intestines!

You know what time it is. It's #FecalFriday!!! (see what you made me do @micromindy?!). Bacteria in white, MUCUS in green and red. Images taken by @GobletCellGuy @MariaNaama_ and @tel_paz

@YaneValdezT Thank you so much Yanet!!

@BergstromLabUBC Awesome Kirk et al 👏👏👏

🚨🚨Ever wondered what human MUC2 is doing at baseline and under pathologic conditions? Some big mucus news to share from the MucinGlycoLab _UBC! #mucusmatters #mucus #IBD 1/11 jbc.org/article/S0021-…

@qchuLiang Thank you Qiaochu!

@BergstromLabUBC Great study! Congrats Kirk et al!

@DC_Genomics Thank you David! Lots more to come!

@BergstromLabUBC Phenomenal tour de force, congrats Kirk and the team at UBC. Looks like just the beginning, we'll all stay tuned for more #mucus & #IBD

@GobletCellGuy Thank you GobletCellGuy! We are happy to add mucus to the microbes, antibodies, proteases, glycosidases, lipids, and metabolites and other biomarkers so richly found in our stools!

Stool, huh, yeah - what is it good for? Well, isolating large quantities of mucus apparently 💥 💥 💥 Interesting new study from the @BergstromLabUBC with implications for mucin/o-glycan therapeutic interventions, check it out 🤓 🧪

@Mucus_Man @k_bergstrom_19 Thank you Mucus Man!!

AWESOME MUCUS STUDY!!! Fantastic work by @k_bergstrom_19, proving that we can work on mucus barrier function in a non-invasive way. This has BIG implications for the study of IBD. Congratulation Kirk and team!!!

@hongbing_yu Thank you Hongbing!

@BergstromLabUBC Congrats, Kirk! Another cool study that will have a big impact on the community.