Antonio C Bianco

525 posts

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Antonio C Bianco

Antonio C Bianco

@Bianco_Lab

Physician-Scientist, Writer ("Rethinking Hypothyroidism"), and Dean @utmb_jssom. #thyroid, #hypothyroidism, #ThyroidDisease, #EndoTwitter.

Galveston, TX Beigetreten Ocak 2014
701 Folgt2K Follower
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Antonio C Bianco
Antonio C Bianco@Bianco_Lab·
Treatment of Hypothyroidism that Contains T3 is Associated with Reduced Risk of Dementia and Mortality. Results from 1.26 million patients with hypothyroidism, 126 health organizations across 17 countries. academic.oup.com/jcem/article-a…
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Antonio C Bianco
Antonio C Bianco@Bianco_Lab·
@LipidSniper @PeterAttiaMD The ratio should be customized for each patient; in general you decrease the dose of LT4 by 25 mcg and introduce LT3 5 mcg. Adjustments follow based on symptoms; TSH levels must remain within normal range.
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Seeking Knowledge
Seeking Knowledge@LipidSniper·
@PeterAttiaMD @Bianco_Lab @bianco_lab In this podcast you state Selenkow (Harvard) tested combinations of T4 to T3 & concluded the best ratio is 3.5:1. Is this your target for combo therapy? In your book you cite this but also say to start with 14:1-20:1 ratio which is confusing. Please clarify. Thank you
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Peter Attia
Peter Attia@PeterAttiaMD·
In episode #373 of The Drive, I sit down with Antonio Bianco, M.D., Ph.D. (@bianco_lab), a world-renowned physician-scientist and expert in thyroid physiology and metabolism. Antonio explores the complex biology of thyroid hormone production, conversion, and regulation. bit.ly/3K4LoiX
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Antonio C Bianco
Antonio C Bianco@Bianco_Lab·
Preexisting hypothyroidism in 5,700 patients undergoing bariatric surgery increases the risks of short and long term adverse outcomes. Risks were higher in patients who underwent gastric bypass academic.oup.com/jcem/article-a…
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Antonio C Bianco
Antonio C Bianco@Bianco_Lab·
@LipidSniper It is due to a disconnect between the D2 in the pituitary and in the other tissues. Exogenous T3 improves. We are submitting that paper soon.
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Seeking Knowledge
Seeking Knowledge@LipidSniper·
@Bianco_Lab Fantastic paper. Why do some patients on T4 only with optimal TSH and Free T4 end up with below range T3? Is it due to deiodinase polymorphisms or some other factor? And does exogenous T3 correct the dyslipidemia? Thank you for groundbreaking work and a fantastic book. Cheers!
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Antonio C Bianco
Antonio C Bianco@Bianco_Lab·
We followed 105 patients before and after developing hypothyroidism (on LT4). Those patients with lower T3 were at risk for dyslipidemia (47.5% vs. 27.3%); even after adjusting for confounders (adjusted OR: 3.6). Monitoring T3 levels should be considered. endocrinepractice.org/article/S1530-…
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Antonio C Bianco retweetet
Antonio C Bianco
Antonio C Bianco@Bianco_Lab·
Treatment of Hypothyroidism that Contains T3 is Associated with Reduced Risk of Dementia and Mortality. Results from 1.26 million patients with hypothyroidism, 126 health organizations across 17 countries. academic.oup.com/jcem/article-a…
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Antonio C Bianco
Antonio C Bianco@Bianco_Lab·
@vegananne @ITC2025 Yes, we have a study under review showing that LT4-treated patients have 30-40% higher risk of developing acute and chronic kidney disease; risks are higher with elevated TSH levels.
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Anne
Anne@vegananne·
@Bianco_Lab @ITC2025 Can suboptimally-controlled hypothyroidism adversely impact kidney health? Thank you for any thoughts.
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Majka Woods
Majka Woods@knitwitphd·
No one was more surprised than me to find out I have worked at UTMB for 10 years as of today. How did I discover this you ask? Well my badge was denied at every entry! Apparently when they issued it they were banking on me staying 10 years or less and had it set to deactivate 🤣
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NIH
NIH@NIH·
🚨 New NIH Public Access Policy goes into effect TODAY! Research accepted for publication on July 1, 2025, must be publicly available as soon as it is published. This date was moved up from December 31, 2025, to ensure radical transparency regarding the research NIH supports. Read more from @NIHDirector_Jay ➡️ go.nih.gov/zQRDiuk
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Antonio C Bianco
Antonio C Bianco@Bianco_Lab·
@EnajaratG The findings are valid only for patients with hypothyroidism. The association between treatment that contains T3 with reduced cases of dementia is very significant. There are between 15 and 20 million patients with hypothyroidism in the US.
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EnajaratG
EnajaratG@EnajaratG·
@Bianco_Lab this is such an important question. Can I surmise that if T3 were tested, and given, more readily, fewer patients would be diagnosed with dementia?
MiketheMaguire@MaguireMikethe

@jimHarwood999 @MaryS58459511 @Bianco_Lab Prof Bianco … this is so important in the context of the immense rise in dementia, such a devastating and expensive to treat & care for condition. Wonder how many folk not diagnosed with hypothyroidism struggle through life with this T3 shortfall time bomb under them?

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Antonio C Bianco
Antonio C Bianco@Bianco_Lab·
@EnajaratG It was good. People liked it and thought the data was convincing.
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EnajaratG
EnajaratG@EnajaratG·
@Bianco_Lab @Bianco_Lab could you share what reception your study had in Rio? I wonder what comments you received?
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Antonio C Bianco
Antonio C Bianco@Bianco_Lab·
Hundreds of surfers watching the sunrise in Copacabana, Rio.
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Antonio C Bianco
Antonio C Bianco@Bianco_Lab·
Over a 20-year follow-up, patients receiving combination therapy (LT4 + T3 or DTE) had a 27% lower risk of dementia and a 31% lower risk of mortality compared to those receiving LT4 alone. Adjusted Cox proportional hazard models confirmed the results.
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Antonio C Bianco
Antonio C Bianco@Bianco_Lab·
This is an impactful study that should reset the approach to the treatment of hypothyroidism. I will show details on Sunday, during the 17th International Thyroid Congress in Rio.
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