Bram De Laere

341 posts

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Bram De Laere

Bram De Laere

@BramDL

Biochemical engineer, PhD medical science @karolinskainst and @ugent, #ProstateCancer, #LiquidBiopsy & @ProBioTrial researcher. Views are my own

Ghent, Belgium Beigetreten Kasım 2016
644 Folgt359 Follower
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Bram De Laere
Bram De Laere@BramDL·
Privileged seeing the @ProBioTrial published in @NatureMedicine My sincerest gratitude for all the dedicated doctors, nurses, lab personnel, trial managers, and most importantly, the patients who made this possible🙏 Thank you @komop_tgkanker for making ProBio possible in🇧🇪
ProBio@ProBioTrial

🔥📢 The first results from the @ProBioTrial have been published in @NatureMedicine 🚀🌟 ARPIs outperform taxanes in metastatic #ProstateCancer: an outcome-adaptive randomized platform trial 🌟 nature.com/articles/s4159… [1/10]

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Michael Saerens
Michael Saerens@msaerens01·
The workflow of #ProBio trial is mindblowing: 14 day TAT to get a ctDNA 🩸🧬genomic profile and personalised treatment option in >5 🇪🇺 countries. Focus shifts to mHSPC setting. @crighent Priomic Symposium @piet_ost @BramDL
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Bram De Laere
Bram De Laere@BramDL·
📉 CDKN1A mutations weren’t tied to NAC response but were linked to worse survival outcomes — hinting at prognostic value regardless of molecular subtype. #Biomarkers 4/5
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Edmond Kwan
Edmond Kwan@EdmondMKwan·
On the eve of #ASCO25, I am delighted to share results from the correlative analyses of the @ANZUPtrials phase II TheraP study, now published in @NatureMedicine. Massive effort supported by dedicated co-investigators, coordinators, patients & families from 11 study sites across Australia 🙏🏼 🧵1/10 nature.com/articles/s4159…
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Piet Ost
Piet Ost@piet_ost·
@medoncodoc @DrSpratticus But if you ask the companies @Merck to provide drug for a biomarker selection trial like @ProBioTrial, they refuse. Even if you ask for compassionate use for PCa MSI high in the trial!!! @BramDL
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Piet Ost
Piet Ost@piet_ost·
📢 STORM trial breaking results at #ESTRO25! 🧪 MDT vs ENRT+MDT for nodal oligorecurrent PCa. 🧬 ENRT+MDT: ✅ Superior bRFS (57% vs 41%, p=0.014) ✅ Superior pelvic control (lrRFS 85% vs 62%, p=0.006) ✅ Superior MFS (76% vs 63%, p=0.06) ❌ No increase in ≥G2 GU/GI toxicity
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Bram De Laere
Bram De Laere@BramDL·
Proud to share the latest insights from the @ProBioTrial Prognostic Value of the Circulating Tumor DNA Fraction in Metastatic Castration-resistant #ProstateCancer 🩸🧬 Full text available on @EurUrolOncol : authors.elsevier.com/sd/article/S25…
ProBio@ProBioTrial

🚨 New Study Alert! 🚨 What if a blood test 🩸 could infer prognosis in advanced prostate cancer? Our latest #ProBio trial study reveals the prognostic power of circulating tumor DNA (ctDNA) 🧬 in #mCRPC A thread 🧵👇 #CancerResearch #ProstateCancer [1/8]

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ProBio
ProBio@ProBioTrial·
🏅Secondary result: We found a linear relationship between ctDNA 🩸 levels and outcome: 📉 Every 10% increase in ctDNA fraction led to a 9% decrease in the observed survival time. 💡 The more ctDNA in🩸, the worse the outcome! #PrecisionMedicine [5/8]
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ProBio
ProBio@ProBioTrial·
🏅Key result: 🧬🩸 Compared to those with detectable ctDNA, men with undetectable ctDNA had ➡️a 60% longer time before treatment stopped working (time to no longer clinically benefiting, NLCB) ➡️a 51% longer overall survival (OS) 📉 #CancerBiomarkers [4/8]
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ProBio
ProBio@ProBioTrial·
🚨 New Study Alert! 🚨 What if a blood test 🩸 could infer prognosis in advanced prostate cancer? Our latest #ProBio trial study reveals the prognostic power of circulating tumor DNA (ctDNA) 🧬 in #mCRPC A thread 🧵👇 #CancerResearch #ProstateCancer [1/8]
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Bram De Laere
Bram De Laere@BramDL·
A privilege to discuss our 🩸🧬 biomarker-driven @ProBioTrial together with @zklaassen_md Thank you @urotoday for the invitation 🙏🏻 ➡️Visit probiotrial.org or @ProBioTrial for more info!
UroToday.com@urotoday

AR pathway inhibitors vs taxanes in #mCRPC #ProBio trial. @BramDL @ugent joins @zklaassen_md @GACancerCenter to discuss the ProBio trial, a groundbreaking platform study in metastatic prostate cancer. Findings show that AR pathway inhibitors often outperform taxane-based chemo in mCRPC, with outcomes influenced by specific genomic markers. #WatchNow > bit.ly/3YXuh6j

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Michiel Strijbos
Michiel Strijbos@StrijbosMichiel·
@Prof_IanD @declangmurphy @neerajaiims @OncoAlert @PCF_Science @urotoday @guconnectinfo @DrChoueiri @montypal @umangtalking @TiansterZhang @Huntsman_GU @AzadOncology @apolo_andrea @shilpaonc @PGrivasMDPhD @Silke_Gillessen That makes zero sense. And a quote from Edison makes it right. Doing 10.000 trials will induce a ton of financial harm, toxicity and delay the development of other strategies. 'FIRST, DO NO HARM'. Thomas Sydenham.
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Jan Vanwelkenhuyzen
Jan Vanwelkenhuyzen@Sj0mpie·
Secondly, my (co)promotors @piet_ost and @kdpreter for giving me the opportunity 5 years ago to start. @BramDL not only for being my boss and scientific mentor but for being a life-long friend that I hold dear.
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Piet Ost
Piet Ost@piet_ost·
Don’t forget the @ProBioTrial is an investigator-initiated trial! Crazy level of commitment of everyone involved.
ProBio@ProBioTrial

Meet the @ProBioTrial consortium: healthcare professionals from 🇸🇪🇧🇪🇳🇴🇨🇭specialised in the treatment of men with metastatic #ProstateCancer They made the 🥈#ProBioTrial International Investigator’s Meeting a success 🙏 Presentations soon available on probiotrial.org

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Entdecken

@crighent @piet_ost @ESMO_Open @ANZUPtrials @NatureMedicine @medoncodoc @DrSpratticus @Merck