Ian Davis (Bluesky @profiand)

Happiness is an empty beach, the wind in your ears, your best friend by your side, and 0/8 feet on the ground

@AnilMakam @pash22 Pfft. In Australia we go one step better. nhmrc.gov.au/guidelinesforg…

Has any academic ever said we have too many unhelpful statements/guidelines based on expert opinion, we shouldnt issue another unless there is good evidence to guide us?

@barttels2 @HeartOTXHeartMD @RitikaTuliMD Also “PFO” meant something completely different in the days I worked in ED. Australian doctors will know what I mean.

@HeartOTXHeartMD @RitikaTuliMD “Diagnosed as or with” 🧐 Hey I don’t make the rules.

🫀 CardioNugget™ Why might a PFO cause Platypnea-Orthodeoxia Syndrome? A PFO alone usually doesn't cause a shunt because LA pressure > RA pressure keeps it functionally closed. In Platypnea-Orthodeoxia Syndrome (POS), an anatomic change (e.g., ascending aortic aneurysm or atrial septal aneurysm) redirects IVC blood toward the PFO when upright, creating a right-to-left shunt. ➡️ Deoxygenated blood bypasses the lungs → ↓ O₂ saturation (orthodeoxia) + dyspnea (platypnea). POS is a problem of abnormal blood flow direction (streaming), not elevated right atrial pressure. #CardioNugget™ #EchoBoards #Cardiology #MedEd #FOAMed #PFO #PlatypneaOrthodeoxia

@EHCSMonash @TurningPointAU

Ever get that feeling you are being watched…?

@ThatEricAlper I am physically incapable of doing this.

New publication! There is great interest in identifying which patients with mHSPC benefit from treatment intensification by adding doce to ADT+ARPI. A newly published AI–based biomarker derived from routine H&E slides addresses this q. Now in JCO PO: ascopubs.org/doi/10.1200/PO…

Germline CDK12 variants in aggressive prostate cancer aacrjournals.org/cancerdiscover… This study identified rare germline CDK12 truncating variants in 5 of 4,535 patients (0.1%) with metastatic #ProstateCancer , challenging the belief that CDK12🧬 alterations are exclusively somatic. All cases demonstrated biallelic CDK12inactivation and the characteristic tandem duplication genomic signature. Germline variants were significantly enriched 🆚 population controls and segregated with prostate and ovarian cancer in affected families, supporting germline CDK12 as a rare hereditary driver of lethal metastatic prostate cancer. @AzadOncology @Prof_IanD @DrMHofman @Ecastromarcos @pcvblack @NivenMehra @piet_ost @OncoAlert 🚨 @Silke_Gillessen @AOmlin @gil

@LifeThruBook @fermatslibrary Thankfully Reviewer 2 had not yet been invented.

@fermatslibrary Imagine if Halley had decided it wasn't worth the expense. One of history's greatest investments. One scientist believed in another, and the world was never the same.

On this day in 1687, Newton’s Principia was published, arguably the most important science book ever printed. The Royal Society couldn’t fund the printing since they’d spent their entire budget on a book about fish. Edmond Halley paid for the Principia out of his own pocket.

Add “-ai” to your search to reduce hallucinations.

Actual exchange: @Google, confidently: you researched estrogen therapy for #ProstateCancer and were instrumental in the PATCH trial. Me: Absolutely not true. G: Yes sorry, I made that up. Me: Well, don’t do that. G: I can’t help it. So yes, if you’re wondering: we’re screwed.

@LiangRhea Exactly. It’s freedom to speak, not “I must be heard” or immunity from consequences. And we all accept some things cannot be permitted to be said (eg false “Fire!” In a theatre). Even the US 1st amendment is only about limiting what government can do about making relevant laws.

People forget that 'free speech', regardless of social approbation or causing offense, is a US concept. In Australia (Karl) and the UK (Piers), speech follows usual social norms of both responsibility and consequence, as do all wilful human actions.

@oncology_bg Congratulations Bishal (and Queens!) and very well deserved!

I officially start as Professor of Oncology at Queen’s University from today. This has been quite an incredible journey from being a fellow to a professor in 8 years. I’m very grateful to everyone who has unwaveringly supported me throughout this, specially my incredible family, friends, mentors, mentees, colleagues, collaborators, and patients. Thank you Queen’s University and Department of Oncology for this honour and recognition through promotion. 🙏🙏

@ethanjweiss Well still east technically as per longitude!

@ethanjweiss And your east is way way west of others like us!

Why is “Pacific Time” not referred to as “Western Time” or why is “Eastern Time” not called “Atlantic Time”?

@AnkushGoyal24 On a rainy day in school holidays, with more young children there than usual.

Eastland shopping centre apparently did safety drill for someone running around with a weapon, WTF? Why do these people act like we are living in some dangerous place and they need to do such time wasting activities

Pretty sure I heard this gem from the radio commentator near the end of the Australia- Paraguay #WorldCupFIFA match: “Australian hearts and bowels were clenched around the stadium”

@f2harrell @piet_ost @bmj_latest This is an excellent and very interesting paper. I could not find any discussion about potential barriers posed by privacy principles and legislation for the use of routinely collected clinical data, and would be very interested in others’ views.

"Real world data" is an almost meaningless phrase. Our new @bmj_latest paper pushes the more helpful phrase "routinely collected data" and explains the many limitations of such for research purposes. doi.org/10.1136/bmj-20… #Statistics

@FredTaming That’s going straight to the pool room.

@Prof_IanD ⭐️

hey look its one of our stealthiest bombers right there in broad daylight