Anthony J Gill

Skin lesion 40 year old male. Who else always undertakes fumarate hydratase IHC and 2SC IHC in cutaneous leiomyomas. We always do. Practice hint, immunohistochemistry for FH can be difficult to interpret in cutaneous leiomyomas. This is because they are always associated with small non-neoplastic nerve fibres which show positive staining even in FH deficient leiomoyomas. In contrast 2SC is always diffusely strongly positive in FH deficient leiomyomas and 2SC is easy to interpret. The presence of any FH deficient leiomyomas is an indication for genetic counselling/testing for germline FH mutation. The presence of multiple leiomyomas is also an indication for genetic counselling/testing regardless of IHC status. So one can make an argument (which sounds a little counterintuitive) that you should always perform FH and 2SC IHC only on apparently solitary cutaneous leiomoyomas The pics below show FH (negative) and 2SC (positive). One more thing . . . dermatologists always want to call this Reed syndrome. I call it HLRCC (hereditary leiomyomatosis and renal cell carcinoma syndrome) as it is the renal carcinomas which are most ominous.

Well Differentiated Papillary Mesothelial Tumor (WDPMT) #TheJPCNCR #PathTwitter

It was a wonderful to hear that an important clinical trial using neoadjuvant combination immunotherapy in selected glioblastoma brain patients has commenced in the USA. The pioneering work, led in Australia by my colleague Prof Georgina Long and the trial team formation led by Dr Jim Whittle, together with an extensive talented team, deserves huge congratulations for their work and initiating the development of the trial! The first patient, based in the USA where the study is led by Professor Mustafa Khasraw, has commenced trial participation. I hope patients in Australia can participate soon. Well done to everyone from the excellent teams involved. I hope the trial is positive for brain cancer patients! Details of the information available can be found through a link to the Sydney Morning Herald with an article written by Garry Maddox. #glioblastoma #braincancer @ProfGLongMIA @MelanomaAus @WEHI_research @carriesB4BC @BrainCancerCtr @gmaddox @smh @NthSydHealth @COBLH @Sydney_Uni @BickmoreCarrie

1/ Just out in @ModernPathology New study from our group: A distinct variant of aggressive lung carcinoma with peculiar pathologic features. We called these tumors “SAGA” (solid and granular adenocarcinoma) .. sorting them out was in fact a long and winding saga that led to some unexpected insights. 👇 modernpathology.org/article/S0893-… pubmed.ncbi.nlm.nih.gov/41580239/

@ProfRAScolyer Go you good thing! Looking good Richard

How is my exercise training going since I tripped over when jogging nearly 2 weeks ago? To be honest, it’s tougher than I thought to get back to normal. I’m training on my indoor bike trainer a lot but not quite there to ride outside or jog. I’m still incredibly excited & looking forward to the big Tour de Cure (TdC) cycling event down in Tasmania (our group is riding 150 k’s per day for 4 days- yikes!!). It will take a lot to hold me back. I have great admiration of TdC and what they have & continue to do to push the cancer field forward for a long period of time! We can all be very proud of the achievements that have occurred already. But there is still work to do to deliver on zero deaths from cancer! @tourdecure_aus @COBLH @SydneyLHD @Sydney_Uni @NthSydHealth #cycling #brainstorm #braincancer #braintumour #glioblastoma

Great Article on this not uncommon problem. I think after reading the article: authors.elsevier.com/a/1mWXy77WluYQV pathologists may have different ideas about whether it is benign or malignant.

Would you diagnose this lesion as parathyroid carcinoma in a patient with chronic renal failure? Find out here - authors.elsevier.com/a/1mWXy77WluYQV

30s M with a renal mass. Diagnosis? #PathTwitter @MGBpathology @MGHPathology

1/ Excited to share the latest paper from our group on lung carcinoids. onlinelibrary.wiley.com/doi/10.1111/hi… pubmed.ncbi.nlm.nih.gov/41489019/ A few comments below:

In surgical pathology, the answer isn't always found at high power. Often it is much easier at lower power, or even macroscopically. As you scroll through the thread, it gets easier and easier until the macrosocpic picture makes it obvious

Yes it is a SEROUS CYSTADENOMA OF THE PANCREAS.

Natural history of #PancreaticCancer arising in an IPMN versus conventional Pancreatic Ductal Adenocarcinoma (PDAC): Long-term Outcomes Following Resection of Adenocarcinoma Arising from Intraductal Papillary Mucinous Neoplasm (A-IPMN) Versus PDAC journals.lww.com/annalsofsurger…

Recent developments in eosinophilic renal neoplasms: what's new, true and important? @Kiril_T_Can @FSiadat @SaleebRola Histopathology Annual GU Path Review 2026 - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/hi…

Fun fact - Doug Reye was an Australian pathologist working at Royal Alexandra Hospital for Children in Sydney. I am old enough to have worked with people who worked with him. Although his name is most well know for Reye's syndrome, he actually described two distinct paediatric tumours with which his name is not as intrincially linked these days but used to be in the olden days. These are pictured below. On the left is inclusion body fibromatosis (previously known as 'infantile digital fibromatosis' or just 'Reye's tumour'). On the right is calcifying aponeurotic fibroma. Whilst not common, these two tumours are much more common than Reye's syndrome

Which condition does this depict?

Australia just recorded zero cervical cancer cases in women under 25 - for the first time since records began in 1982. This is what happens when a country commits to HPV vaccination and screening. We protect our girls and save lives.