This is a high power field from a hibernoma (a lipoma showing brown fat differentiation). The nuclei are tiny. These tumors are richly vascularized like brown fat.
English
Modern Pathology
1.4K posts
Modern Pathology
@ModernPathology
Official Journal of @TheUSCAP, focused on clinical and translational research in #pathology of #humandisease. Sibling Journal: @LIjournal.
Palm Springs, CA Katılım Ocak 2017
271 Takip Edilen14.1K Takipçiler
This is an example of fat atrophy in a colon resection from a malnourished patient. It can suggest a liposarcoma but the lobulation is the clue.
English
Schneider JW, Eason AB, Chambers M, Su H, Shifflett K, Guo S, Sanderson M, Bruce-Brand C, Burger H, Dittmer DP. Spatial Profiling Shows That Lymphatic Endothelial Cells Form the Core of Kaposi Sarcoma (KS). Mod Pathol. 2026 Feb;39(2):100955. PMID: 41478362; PMCID: PMC12860498.
Modern Pathology@ModernPathology
Kaposi sarcoma - note the hyaline globules (arrow). It is derived from lymphatic endothelium - confirmed a new way in Modern Pathology. Schneider JW, et al. PMID: 41478362; PMCID: PMC12860498.
English
Kaposi sarcoma - note the hyaline globules (arrow). It is derived from lymphatic endothelium - confirmed a new way in Modern Pathology.
Schneider JW, et al. PMID: 41478362; PMCID: PMC12860498.
English
Sande WJ, et al. Extraaxial Poorly Differentiated Chordoma: Clinicopathologic and Molecular Genetic Characterization. Mod Pathol. 2025 Mar;38(3):100664. PMID: 39577663.
Modern Pathology@ModernPathology
This is a rather classic chordoma that has spread to the patient's lung, but there is lots more afoot! Modern Pathology helps us keep up! Sande WJ, et al. PMID: 39577663.
English
This is a rather classic chordoma that has spread to the patient's lung, but there is lots more afoot! Modern Pathology helps us keep up!
Sande WJ, et al. PMID: 39577663.
English
Simons M, et al. Two types of primary mucinous ovarian tumors can be distinguished based on their origin. Mod Pathol. 2020 Apr;33(4):722-733. PMID: 31695154.
Modern Pathology@ModernPathology
Although there is an association between ovarian primary mucinous tumors and Brenner tumors, in this case, a Brenner tumor has collided with metastatic pancreatic ductal adenocarcinoma. Mod Pathol. 2020 Apr;33(4):722-733. PMID: 31695154.
English
Although there is an association between ovarian primary mucinous tumors and Brenner tumors, in this case, a Brenner tumor has collided with metastatic pancreatic ductal adenocarcinoma.
Mod Pathol. 2020 Apr;33(4):722-733. PMID: 31695154.
English
Iwamura R, et al. PDGFRB and NOTCH3 Mutations are Detectable in a Wider Range of Pericytic Tumors, Including Myopericytomas, Angioleiomyomas, Glomus Tumors, and Their Combined Tumors. Mod Pathol. 2023 Mar;36(3):100070. PMID: 36788105.
Modern Pathology@ModernPathology
An interpretation of myofibroma (and some related lesions) can be confirmed by in situ hybridization for PDGFRB. Mod Pathol. 2023 Mar;36(3):100070. PMID: 36788105.
An interpretation of myofibroma (and some related lesions) can be confirmed by in situ hybridization for PDGFRB.
Mod Pathol. 2023 Mar;36(3):100070. PMID: 36788105.
English
Montgomery EA, Devaney KO, Giordano TJ, Weiss SW. Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg-like cells: a distinctive lesion with features simulating inflammatory conditions, Hodgkin's disease, and various sarcomas. 9578090
Modern Pathology@ModernPathology
Myxoinflammatory fibroblastic sarcoma was first reported in Modern Pathology years ago using descriptive terminology by Sharon Weiss and her colleagues. Reed-Sternberg like cells (large arrows) and an eosinophil are indicated. PMID: 9578090.
English
Myxoinflammatory fibroblastic sarcoma was first reported in Modern Pathology years ago using descriptive terminology by Sharon Weiss and her colleagues. Reed-Sternberg like cells (large arrows) and an eosinophil are indicated.
PMID: 9578090.
English
Everyone's onto loss of GI tract plasma cells in patients on CAR T treatment for myeloma, but there is always daratumumab to fool us as well! Modern Pathology comes to the rescue again to help us in practice! Read all about it!
sciencedirect.com/science/articl…
English
This pancreatic solid pseudopapillary neoplasm compressed the kidney. There is lots to learn!
He R, et al. Proteomics Profiling Identifies MCM4 as a Prognostic Biomarker for Postoperative Metastasis in Solid Pseudopapillary Neoplasms of the Pancreas. PMID: 41638574.
English
A SMARCA4 (BRG1) deficient esophageal carcinoma. Keratin expression was sparse.
Neil AJ, Zhao L, Isidro RA, Srivastava A, Cleary JM, Dong F. SMARCA4 Mutations in Carcinomas of the Esophagus, Esophagogastric Junction, and Stomach. Mod Pathol. 2023 Jun;36(6):100183. PMID: 37054973
Română
This small intestinal histiocytic sarcoma had an NF1 mutation.
Shanmugam V, Griffin GK, Jacobsen ED, Fletcher CDM, Sholl LM, Hornick JL. Identification of diverse activating mutations of the RAS-MAPK pathway in histiocytic sarcoma. Mod Pathol. 2019 Jun;32(6):830-843.
English
This HPV-associated anal lesion most likely harbors a CYLD mutation based on the morphology. It is essentially a basaloid variant of squamous cell carcinoma that produces peculiar basement membrane material.
Williams EA, Montesion M, Sharaf R, Corines J, Patel PJ, Gillespie BJ, Pavlick DC, Sokol ES, Alexander BM, Williams KJ, Elvin JA, Ross JS, Ramkissoon SH, Hemmerich AC, Tse JY, Mochel MC. CYLD-mutant cylindroma-like basaloid carcinoma of the anus: a genetically and morphologically distinct class of HPV-related anal carcinoma. Mod Pathol. 2020 Dec;33(12):2614-2625. PMID: 32461623; PMCID: PMC7685972.
English
This is a classic bland-appearing ossifying fibromyxoid tumor of soft tissue that would be associated with a favorable outcome. Note the focal shell of bone. Loss of RB protein is associated with malignant behavior.
Hofvander J, Jo VY, Fletcher CDM, Puls F, Flucke U, Nilsson J, Magnusson L, Mertens F. PHF1 fusions cause distinct gene expression and chromatin accessibility profiles in ossifying fibromyxoid tumors and mesenchymal cells. Mod Pathol. 2020 Jul;33(7):1331-1340. PMID: 31932680.
English
SMAD4/DPC4 deficient colorectal carcinomas can be particularly aggressive, masquerading as "carcinomas of unknown primary" and presenting with widespread disease - they maintain a colorectal phenotype. This article offers a comprehensive look.
Mirzabeigi Y, Shah N, Schwartz KR, Duryea J, Delma KS, Montgomery EA, Poveda JC, McDonald OG. High-Grade Colorectal Adenocarcinomas With SMAD4 Deficiency. Mod Pathol. 2026 Jan 6;39(3):100957. Epub ahead of print. PMID: 41506325; PMCID: PMC12814370.
English
Esophagitis dissecans superficialis, also known as sloughing esophagitis, is associated with infirmity and polypharmacy. Modern Pathology provided a vintage study on this self-limiting condition.
Purdy JK, Appelman HD, McKenna BJ. Sloughing esophagitis is associated with chronic debilitation and medications that injure the esophageal mucosa. Mod Pathol. 2012 May;25(5):767-75. PMID: 22282305.
English