Modern Pathology

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Modern Pathology

Modern Pathology

@ModernPathology

Official Journal of @TheUSCAP, focused on clinical and translational research in #pathology of #humandisease. Sibling Journal: @LIjournal.

Palm Springs, CA Katılım Ocak 2017
270 Takip Edilen14.2K Takipçiler
Modern Pathology
Modern Pathology@ModernPathology·
Serotonin-producing pancreatic neuroendocrine tumors often have a peculiar sclerotic appearance. Depoilly T, eet al. Immunophenotypic and molecular characterization of pancreatic neuroendocrine tumors producing serotonin. Mod Pathol. 2022 Nov;35(11):1713-1722. MID: 35739266.
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Modern Pathology
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The gang in Miami sees plenty HPV-associated anal glandular lesions - but you might be missing them- check it out! Mirzabeigi Y, et al. Expanding the Spectrum of High-Risk Human Papilloma Virus (HPV)-Associated Glandular Neoplasms of the Anorectum. Mod Pathol. PMID: 42392453.
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Jia Q, Chen Y, Pan Y, Gao S, Wei X, Fan Y, Li P, Yang Z, Pu J, Nan P, Chang H, Zheng J, Zhang G, Liu X. Clinicopathologic and Genomic Characterization of SMARCA4-Deficient Carcinoma of the Gallbladder. Mod Pathol. 2025 Nov;38(11):100868. PMID: 40789532.
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SMARCA4/BRG1 deficient carcinomas have been reported all over the body - including in Modern Pathology (gallbladder most recently). This one was in the small intestine! Jia Q, et al. PMID: 40789532.

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Modern Pathology@ModernPathology·
SMARCA4/BRG1 deficient carcinomas have been reported all over the body - including in Modern Pathology (gallbladder most recently). This one was in the small intestine! Jia Q, et al. PMID: 40789532.
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There might be a CISH, but finding hemosiderin deposition is a poor man's clue. Dulken BW, et al. CHRNA6 RNA In Situ Hybridization Is a Useful Tool for the Diagnosis of Extraskeletal Myxoid Chondrosarcoma. Mod Pathol. 2024 May;37(5):100464. PMID: 38447752.
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Modern Pathology
Modern Pathology@ModernPathology·
Bread and butter post: Inflammatory cloacogenic polyp is a mucosal prolapse polyp at the junction of rectal glandular mucosa and anal squamous mucosa. Note that the the lamina propria is filled with smooth muscle rather than the usual complement of inflammatory cells.
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Modern Pathology
Modern Pathology@ModernPathology·
Mastocytosis (seen here) is often sought by naive colleagues and seldom seen. Mod Pathol offers a great review: Panarelli NC, Hornick JL, Yantiss RK. What Is the Value of Counting Mast Cells in Gastrointestinal Mucosal Biopsies? Mod Pathol. 2023 Feb;36(2):100005. PMID: 36853780.
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There is a lot happening with squamous cell carcinoma. This esophageal example has a null p53 expression pattern. Check out this new article! Zhang AW, et al PMID: 40902853.
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This is a gastric mucosal biopsy: The clue to this "one stain diagnosis" is that GISTs seldom involve the mucosa. Ortiz Requena D, et al. Synovial Sarcoma of the Gastrointestinal Tract. Mod Pathol. 2024 Jan;37(1):100383. PMID: 37972927.
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This is a high power field from a hibernoma (a lipoma showing brown fat differentiation). The nuclei are tiny. These tumors are richly vascularized like brown fat.
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Modern Pathology
Modern Pathology@ModernPathology·
This is an example of fat atrophy in a colon resection from a malnourished patient. It can suggest a liposarcoma but the lobulation is the clue.
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Schneider JW, Eason AB, Chambers M, Su H, Shifflett K, Guo S, Sanderson M, Bruce-Brand C, Burger H, Dittmer DP. Spatial Profiling Shows That Lymphatic Endothelial Cells Form the Core of Kaposi Sarcoma (KS). Mod Pathol. 2026 Feb;39(2):100955. PMID: 41478362; PMCID: PMC12860498.
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Kaposi sarcoma - note the hyaline globules (arrow). It is derived from lymphatic endothelium - confirmed a new way in Modern Pathology. Schneider JW, et al. PMID: 41478362; PMCID: PMC12860498.

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Modern Pathology@ModernPathology·
Kaposi sarcoma - note the hyaline globules (arrow). It is derived from lymphatic endothelium - confirmed a new way in Modern Pathology. Schneider JW, et al. PMID: 41478362; PMCID: PMC12860498.
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This is a rather classic chordoma that has spread to the patient's lung, but there is lots more afoot! Modern Pathology helps us keep up! Sande WJ, et al. PMID: 39577663.
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Although there is an association between ovarian primary mucinous tumors and Brenner tumors, in this case, a Brenner tumor has collided with metastatic pancreatic ductal adenocarcinoma. Mod Pathol. 2020 Apr;33(4):722-733. PMID: 31695154.
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An interpretation of myofibroma (and some related lesions) can be confirmed by in situ hybridization for PDGFRB. Mod Pathol. 2023 Mar;36(3):100070. PMID: 36788105.
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