Jake Scott

🚨 New in @JClinInvest 🚨 HPV+ oropharynx patients do not all benefit equally from the same radiation dose. Our study shows that genomics (via GARD) can guide personalized RT de-escalation—safely sparing toxicity without losing cure. Paper 👉 doi.org/10.1172/JCI194… #ASTRO25

@EricTopol What if we could engineer the liver to make (any!) BiTEs instead? clinicaltrials.gov/study/NCT06533…

What if we could engineer T cells in the body, making CAR T vs cancer, autoimmune diseases, and other applications far more practical, much less expensive? A step forward today via genome editing T cells nature.com/articles/d4158… nature.com/articles/s4158…

5-yr PFS and OS showed a clear stepwise gradient by lesion count. Oligomets is a spectrum, not a binary state.

🎉 After 3 yr of work, our paper is finally accepted in @IJROBP! authors.elsevier.com/sd/article/S03… MDT for breast OMD remains highly controversial — NRG-BR002, CURB, and EXTEND all came back negative. So we asked: What actually happens when MBC progresses and can ctDNA predict it?

A historical milestone occurred today at the Michael E. DeBakey VA Medical Center, where the VALOR study team, led by @LorraineC_MD, enrolled the 500th participant! Congratulations to her team and everyone involved in this randomized phase III study. #CSP2005 vacsp.research.va.gov/CSP_2005/CSP_2…

CWRU’s @cancerconnector has been named a 2026 Senior Member of the @AcadofInventors. His groundbreaking work in mathematical oncology and radiation genomics is transforming how cancer is understood and treated. Read more: brnw.ch/21x0uOz

Now that I’m a middle-aged parent I suddenly I have deep emotional empathy for every NPC I ditched at the tavern when I went off questing.

If you read one thing this week, read today's @nytimes piece by @SimarSBajaj bit.ly/49ABdvd It names a truth people with #lungcancer live with every single day. This well-written article makes it clear that stigma doesn't just hurt people emotionally; it is a life or death barrier. People delay diagnosis, care, and support because they're afraid of being judged. Lung cancer is not a morality story. And nicotine addiction isn't a bad habit or personal failure - It's a DISEASE and should be treated that way, with compassion and evidence-based care, not judgment. Thank you, @JimPantelas, for always being so open and honest. And thank you, @drCarterBawam, @hawkeyestudts, @NarjustFlorezMD, and others, for continuing to remind people of the most basic truth: no one 'earns' this disease and no one 'deserves' it! Please help change the conversation and shift the narrative from shame and blame to hope and humanity. #KilltheStigma #LCSM #WordsMatter

🔥🚨Hot off the press! 👉Pleased to share our commentary in @ASCO journal @JCO_ASCO 👉👉 Is It Time to Retire the Unified Cancer of Unknown Primary Concept in the Precision Oncology Era? 👉CUP isn't one disease-it's many. Time to treat biology, not labels. #CUP #PrecisionOncology 👉Read the paper+ share your comments @OncoAlert ascopubs.org/doi/full/10.12…

Requiem. Verdi’s Requiem. 🤯 Three chances to catch it at Severance Music Center: Thursday, January 15th at 7:30 PM Saturday, January 17th at 7:30 PM Sunday, January 18th at 3:00 PM Next stop: New York (Carnegie Hall) and Miami (Adrienne Arsht Center) 🌴🗽

📢The February issue of the #RedJournal is out and it has soooo much great #radbio in it🔥🔥🔥 Where to begin❓ Highly timely review: Radiation-Induced Lymphopenia: From Mathematical Modeling Toward Mechanistic Learning ‼️ ⚠️OPEN ACCESS redjournal.org/article/S0360-… With accompanying commentary by @CGrassberger & Team🙏🙏🙏 ⚠️redjournal.org/article/S0360-…

"All models are wrong, and yours is useless." - Markowetz, 2024

Screening!!!! That’s the answer.

This is a counter on Santa Monica Blvd, just down the road from UCLA, that resets every NYE. Let's hope someday the number stays at 0 for all 365 days! instagram.com/reels/DS9hi4RE…

Love this team and so proud of our residents. Incredible to see their accomplishments.

#precisiononcology @OHSUKnight @CDV_MD

@DrewMoghanaki @ChiFuJeffYang @alexandra_p_24 @LeciaSequist @max_diehn @CancerConnector Thank you Drew for spotlighting this! And I agree with you — LDCT >> Liquid biopsy for lung cancer screening given the current technology. Not there yet technologically but this last figure from Mathios et al @NatureComms suggests a future where liquid bx could prescreen -> LDCT

@ScottBratman @max_diehn @CancerConnector @DrSanjayPopat Next up was @aadel_chaudhuri reiterating the limitations of ctDNA for the detection of precancerous and stage I tumors.

@ScottBratman @max_diehn @CancerConnector @DrSanjayPopat @aadel_chaudhuri The most sobering of all slides was this, which represents my anecdotal experience trying to manage pts with Galleri-detected NSCLC (always stage III or higher). It seems ctDNA screened cancers lead to WORSE outcomes compared to being detected by chance alone.

What is SABR (or SBRT)? With James Hiter, an endurance runner living with lung cancer. @jillfeldman4

Subcutaneous Amivantamab is FINALLY @US_FDA approved! This is huge for patients and families because it reduces both time and physical burden: 👉 Decrease infusion reaction & less VTE 👉 Potentially (exploratory and needs longer follow-up/confirmation) a greater efficacy vs IV 👉 JUST AS IMPORTANT: Minutes vs hours of precious time. 5-minute administration vs hours of IV administration changes the logistics of living with cancer. It means more time living and less time in an infusion chair. The hidden toll of cancer that rarely shows up on a curve is time toxicity. It's real, and it matters. THIS is what progress looks like: less time, less toxicity, MORE LIVING! #LCSM