Eric Topol

A new cover for SUPER AGERS after making the NYT bestseller list. Thanks to you for making it the #1 ranked new non-fiction book on Amazon. amazon.com/gp/new-release…

For 12 years, @JoannaStern was the @WSJ tech journalist. In 2025, she spent a year ALL IN with AI, evaluating >100 products, and wrote a book that serves as both a great AI primer and a brutally honest assessment. She's also so funny (AI called her the next Tina Fey). Here's a clip erictopol.substack.com/p/an-ai-immers…

@nntaleb @otrasenda_AC right...needs to be explored

@EricTopol @otrasenda_AC Yes, but I was wondering if there was a way to see if energy deficit prior to weight loss does it (that is, the stressor not the result).

I wonder if one can find a statistical methodology for evidence separating a) these are uniquely caused by GLP-1, or b) caused by *accelerated* weight loss (not just weight loss, but the stressor of severe energy deficit). cc:@otrasenda_AC

The progress and intensity of clinical research efforts with antibody-drug conjugates vs cancer is remarkable A new @CellCellPress review cell.com/cell/fulltext/…

Thank you, @EricTopol! It has been a true pleasure collaborating on this perspective. Amazing to see how rapidly our understanding of this long-overlooked organ is evolving, and how AI and imaging may help make immune system health measurable at scale.

The key Figure from a 2020 publication on a hantavirus outbreak, buried in the supplement of the paper. @donmilton, an international authority on airborne transmission and respiratory viruses, discussed this with me yesterday. erictopol.substack.com/p/assessment-o…

We could pick up risk of cancer and detect it much earlier if we applied LLMs to electronic health records, as shown in this @AllofUsResearch study nature.com/articles/s4169…

Challenging medical dogma, our understanding of the thymus and its impact on our health throughout lifespan has been completely revamped w/ @HugoAerts @TheLancet thelancet.com/journals/lance…

Worth your time. A brilliant conversation between @Don_Milton and @EricTopol about how aerosol transmission works, and why it’s relevant to the hanta outbreak open.substack.com/pub/profairbor…

Busting the NAD+ age biomarker and supplement story —Levels don't go down with age nature.com/articles/s4225… —Lack of evidence for decline npr.org/2026/05/11/nx-… "a potential therapy because of evidence that our levels decline as we get older" @NPR

More direct evidence on the danger of microplastics in human tissue: in GI cancer a higher rate of symptoms, inflammation and recurrence. Present in 56% of patients, just as was seen in carotid atherosclerotic study. nature.com/articles/s4436…

Our retina image is so rich with information, a gateway to the whole body, well beyond the eye. Today add osteoporosis to the list. journals.plos.org/digitalhealth/… This adds to what I recently wrote about at Ground Truths erictopol.substack.com/p/the-paradox-…

Our open letter today on autonomous driving and prevention of serious accidents and road deaths w/ @slotkinjr Adding signatories for those supportive opmed.doximity.com/articles/an-op…

A multimodal AI (AIME) had superior performance compared with 18 physicians for almost every metric (29 of 32 axes). Randomized, but simulated, not real-world clinical practice. @GoogleDeepMind @alan_karthi @RyutaroTanno nature.com/articles/s4159…

Incriminating aged T cells for their influence on cognitive decline @ImmunityCP cell.com/immunity/fullt…

@DShaywitz @WSJ Yes, sharp review of AI For Good and this one. You’re a master at doing these

I reviewed this book (along w another interesting book about AI implementation) in last weekend's @WSJ - (gift link) -> wsj.com/arts-culture/b… . Concluding graf below...

Just a few conditions being pursued for secondary prevention or treatment by GLP-1/GIP/Glucagon drugs in a new and comprehensive review @NatRevDrugDisc

Measruing tissue senescence and effect of therapy via the urine nature.com/articles/s4358… nature.com/articles/s4358…

Good and succinct translation of this important study documenting U-curves for sleep duration, @nature, @heidiledford nature.com/articles/d4158…

“the potential of sleep optimization to promote healthy ageing, lower disease risk and extend longevity.” @Nature Linking biological clocks and sleep data nature.com/articles/s4158…