Systems & Population Genetics Group | O. Delaneau

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Systems & Population Genetics Group | O. Delaneau

Systems & Population Genetics Group | O. Delaneau

@DelaneauGroup

Olivier Delaneau's research group - Department of Computational Biology, University of Lausanne, Switzerland.

Beigetreten Nisan 2020
54 Folgt257 Follower
Systems & Population Genetics Group | O. Delaneau
Systems & Population Genetics Group | O. Delaneau@DelaneauGroup·
We found that: 1. Taking post-mortem damage (PMD) into account before imputation improves imputation accuracy of highly damaged genomes 2. Imputation is robust to moderate levels of PMD 3. Imputation performance breaks down for contamination>5%
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Robin Hofmeister
Robin Hofmeister@Rbn_Hfmstr·
📢 New preprint alert! Refining SHAPEIT5 haplotypes using whole genome sequencing reads. 🧬On #UKbiobank, it confirms a fascinating trend-de novo mutations are more often paternally inherited. 👏 to Rick Wertenbroek and @ODelaneau for this smart work! biorxiv.org/cgi/content/sh…
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Robin Hofmeister
Robin Hofmeister@Rbn_Hfmstr·
Hi #ASHG2023 ! 👋 Interested in the UK Biobank phased data I presented yesterday? Accessible to approved UKB researchers via #dnanexus. --> Meet @ODelaneau at poster 4261 today at 2:15 to delve into the application of these haplotypes for genotype imputation!
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Olivier Delaneau
Olivier Delaneau@ODelaneau·
🎉 Thrilled to share a major career update! 🎉 I'm honored to join the Regeneron Genetics Center as Director in Statistical Genetics. Sad to bid farewell to Lausanne, but eager to contribute to the groundbreaking research done at the RGC! 🧬🖥️📊
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Systems & Population Genetics Group | O. Delaneau
Systems & Population Genetics Group | O. Delaneau@DelaneauGroup·
Check out the newest papers of our group released today in @NatureGenet ! Big thank to all contributing authors @simrubk @Diogo_M_Ribeiro @Rbn_Hfmstr Barbara Mota and @ODelaneau
Olivier Delaneau@ODelaneau

So excited to share our recent work! 🎉 Just released 2 innovative tools in Nature Genetics: nature.com/articles/s4158… nature.com/articles/s4158… Huge applause to my great team of brilliant researchers who made this possible! Stay tuned for deeper insights.

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Robin Hofmeister
Robin Hofmeister@Rbn_Hfmstr·
Great talk at #eshg2023 by @simrubk on low coverage imputation from UK biobank WGS reference panel! Spoiler alert: The 200k UKB WGS reference panel will be available to UKB approved researchers in a few weeks, together with snp-array and low-cov imputation pipelines.
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SIB
SIB@ISBSIB·
@cbg_ethz @ETH_en @TanjaStadler_CH “A clever computational approach allowing to infer which genes an individual inherited from their parents without having any information on them." 🥁That’s what the committee said about this work, one of the #SIBRemarkableOutputs 2022👏 👉 Find out more: tinyurl.com/mwvvjpn
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Liza Darrous
Liza Darrous@LizaMGD·
Our pre-print is out 🎉! Read below on how we performed informative clustering of BMI SNPs using PheWAS data of 400+ traits, this revealed several SNP groups that were enriched for distinct trait themes like body lean mass, job type and education, nutritional supplements..🧵👇1/4
medRxiv@medrxivpreprint

PheWAS-based clustering of Mendelian Randomisation instruments reveals distinct mechanism-specific causal effects between obesity and educational attainment medrxiv.org/cgi/content/sh… #medRxiv

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Systems & Population Genetics Group | O. Delaneau
Systems & Population Genetics Group | O. Delaneau@DelaneauGroup·
Excited to share our study characterizing cell-specificity in key immune cells by mapping regulatory regions with coordinated activity. This valuable insight can aid in interpreting GWAS findings related to complex human diseases. Thanks to all coauthors !
Communications Biology@CommsBio

Analysis of cis-regulatory domains derived from ChIP-seq peaks and methylation data in 3 key immune cells suggests cell-type specific regulatory mechanisms of immunity. @DianaAvalosM, @dermitzakis, @ODelaneau, @DelaneauGroup, @Diogo_M_Ribeiro, @AnnaRamisch nature.com/articles/s4200…

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Systems & Population Genetics Group | O. Delaneau
Systems & Population Genetics Group | O. Delaneau@DelaneauGroup·
We are happy to share the version 2 of our low-coverage imputation software, GLIMPSE2! @dbc_unil @unil
Simone Rubinacci@simrubk

I am very excited that our new study presenting the GLIMPSE2 method is now available on @biorxivpreprint This is a major advance in low-coverage WGS imputation. We made our method scalable to reference panels containing hundreds of thousands of samples. biorxiv.org/content/10.110…

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DMF UNIL
DMF UNIL@DMF_UNIL·
We are shocked and saddened by the terrible news that our dear colleague Alma Dal Co suddenly passed away. She will dearly missed and we wish strength and courage to her family, friends, students and colleagues. Room GEN2024 is open to pay tribute and leave a message.
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Entdecken

@SciReports @simrubk @ODelaneau @AnnaSapfo @dbc_unil @ISBSIB @Rbn_Hfmstr @NatureGenet