Dermal Cell News

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🔬 Scientists identify mitochondrial DNA release as a pivotal event linking oxidative stress to immune activation in #keratinocytes. 🔎 go.nature.com/4uDD9wz

In this study, research explore the discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis Learn more here: 🔗 go.nature.com/4cxlVKW

Here's something to bookmark! 🔖 Scientists systematically synthesizes contemporary advances in extracellular vesicles hydrogel systems for chronic wound therapy. Learn more here: bit.ly/4uFzNJQ

Researchers developed a multi-scale tissue modeling framework to more realistically study the wound healing process in silico with detailed cellular mechanical interactions and geometric changes. 🔖 bit.ly/4bx9OeF

New from @Dev_Cell! 🆕 Dr. Terry Lechler and @DukeU researchers show that in mouse and human epidermal cells, translational machinery is enriched at the cell cortex, where a large subset of mRNAs is also localized. 🧫 📄 Abstract: bit.ly/471hioS

Using models of cutaneous squamous cell carcinoma combined with genetically engineered mouse models of #psoriasis, @MedUni_Wien scientists investigate how chronic skin and systemic inflammation affects squamous skin tumor initiation and progression. 🔗 bit.ly/4bhNkhC

In this @SciReports article, scientists treated a #melanoma cancer cell line with near saturating doses of an allosteric ERAP1 inhibitor and compared metabolite homeostasis to untreated and knock-out cells. 🧫 Read about their findings! 🔗 go.nature.com/4rvaYNQ

Staphylococcal enterotoxin-producing #StaphylococcusAureus promotes skin barrier impairment in cutaneous T cell lymphoma through cytokine-driven, JAK-dependent repression of structural proteins in #Keratinocytes. 💡Read the paper in @AllergyEaaci: bit.ly/4sBzRZ5

Scientists with Dr. Veli-Matti Kähäri hypothesize that upregulation of complement C1s in cutaneous squamous cell carcinoma not only contributes to tumor progression but also serves as a protective mechanism against TRAIL-induced apoptosis. 🔗 go.nature.com/4cDOne5

🧬 The authors synthesize the evolving biomarker landscape across genetic, immune, proteomic, and digital/imaging biomarkers. They highlight therapeutic responses diverge markedly from those of cutaneous disease. 👉 bit.ly/4rSwVr7

🐀 Researchers examined the therapeutic potential of the neuropeptides neurotensin and substance P in reshaping inflammatory and microbial dynamics and accelerating wound closure in healthy and streptozotocin-induced diabetic mice models. @SciReports | go.nature.com/3OQsluL

🧫 Researchers developed injectable photo-cured methacrylated collagen-keratin interpenetrating network hydrogels for rapid enhanced wound healing. 🔗 bit.ly/4l58wMc

🧪 Investigators elucidated the potential mechanism of a traditional therapy for #vitiligo and identified CASP7 and EP300 as potential key targets. Fufang Baizhi Tincture was found to regulate melanocyte apoptosis and transcription. 🔗 bit.ly/4799WQ5

🔬 The authors found that a specific protein, lamin B receptor (LBR), gets overproduced in aggressive #melanoma. This identifies LBR as a potential therapeutic target in the prevention of melanoma metastasis. @PNASNews | bit.ly/46mracv

Scientists, led by Drs. Michelle Baird & Clare Waterman, show that upregulation of lamin B receptor (LBR) in #melanoma promotes nuclear deformability, while LBR’s sterol reductase activity causes fragility and instability of the nuclear membrane. 📖 Read more in @PNASNews: bit.ly/46mracv

Researchers reveal that Salinomycin increases expression of autophagy proteins through ER stress-mediated calcium release and p38 MAPK activation. Inhibiting autophagy using chloroquine or 3-methyladenine increased Salinomycin’s cytotoxic effects. #melanoma @SciReports | go.nature.com/4kZARDW

Dr. David Silver and team from @dukenus demonstrate that Mfsd2a, a lysophosphatidylcholine (LPC) transporter, is predominantly expressed in #keratinocytes and mediates the uptake of a plasma-derived LPC fluorescent probe. 💡 More in @PNASNews: bit.ly/4cMzDtp

Collaborators developed a biocompatible, ROS-responsive hydrogel platform for the local delivery of miR-665, which effectively attenuated inflammatory signaling and stimulated hair follicle regeneration in #alopecia areata. 🔗 bit.ly/3MOpVfB

Researchers demonstrated the presence of programmed necrosis in #psoriasis. Inhibiting necroptosis can significantly reduce inflammation in vivo, causing the improvement of clinical phenotypes and the reduction of proinflammatory factors. 💡 Learn more in @cddpress: go.nature.com/3ORKiJg

.@sangerinstitute's Dr. Carla Robles-Espinoza led this study showing that genetic ancestry may play a key role in how acral #melanoma develops and behaves. The findings were recently published in @Nature. Congratulations to all the authors! 👏 📖 Give it a read: go.nature.com/4cEt3oI