CDD press

Death on the Beach: Cell Death & Disease 32nd ECDO Conference 📍Favignana, Italy 🗓️ 16-19 September 2026 📌 Abstract submission deadline: 30 June 2026 More info: ecdo2026.com Preliminary programme: ecdo2026.com/ecdo2026-progr… @ECDOorg #CellDeath #Conference

“Remodeling of ferroptotic necroinflammation by dexamethasone in acute tubular necrosis” This study demonstrates that #dexamethasone exerts temporally divergent effects on #ferroptosis during #AcuteKidneyInjury ⤵️ nature.com/articles/s4141…

"UbiDash: an open proteogenomic atlas of the ubiquitin-proteasome system across 11 cancers, revealing mutation- and lineage-specific E3 ligase vulnerabilities to guide rational degrader design" By @TaniaJGonzalez, @paganolab nature.com/articles/s4141… 3/3

"Pan-cancer proteogenomic atlas of the ubiquitin-proteasome system reveals mutation- and lineage-specific E3 ligase vulnerabilities and introduces UbiDash, an open-access platform to explore UPS remodeling and prioritize degraders across human cancers" nature.com/articles/s4141… 2/3

"The landscape of the ubiquitin-proteasome system in cancer" An elegant editorial written by Prof. Amir Orian and #Nobel laureate Aaron Ciechanover ⤵️ nature.com/articles/s4141… Read more about the two related research articles in the thread below 1/3

A new way to modulate #ImmuneSuppression in NSCLC: Tumour-infiltrating regulatory #Tcells in #LungCancer rely on the pro-survival protein MCL-1. Blocking MCL-1 can weaken Tregs and briefly boost anti-tumour CD8+ T cells ⤵️ @ml_labat nature.com/articles/s4141…

“Targeting of Gpx8-CSF1 axis resets the immune milieu of lung tumor and overcomes resistance to anti-PD-1 therapy” New insights into the role of Gpx8 in modulating the tumor microenvironment ⤵️ nature.com/articles/s4141…

“Impact of BECLIN1 haploinsufficiency on goblet cell function and susceptibility to colitis” These findings establish BECLIN1 as a molecular rheostat that fine-tunes epithelial organisation and mucosal defence ⤵️ nature.com/articles/s4141…

“SNORA23-KDM5C epigenetic axis mediates dual DNA repair pathways to drive radioresistance in esophageal squamous cell carcinoma” Beyond their canonical role, snoRNAs can modulate chromosomal localization of epigenetic factors to regulate gene expression nature.com/articles/s4141…

“AURKA regulates LGR5 in response to Helicobacter Pylori infection by modulating its deubiquitination” Aurora kinase A regulates LGR5 in #GastricCancer ⤵️ @elrifai23 nature.com/articles/s4141…

“S-phase targeted treatment triggers caspase-dependent lytic immunogenic cell death with pyroptotic features in cancers” Killing cancer cells in S phase promotes a caspase-dependent immunogenic #CellDeath through redundant pathways ⤵️ @BrianGabri46654 nature.com/articles/s4141…

“Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation” Don't miss this new Comment by Prof @BoyiGan and colleagues in CDD ⤵️ nature.com/articles/s4141…

“Multi-omic single nuclei profiling of murine pancreas shows dynamic epigenetic heterogeneity of acinar cells” Paired sequencing of cell #Transcriptome and #Epigenome reveals surprising tissue heterogeneity and mechanisms of tissue homeostasis ⤵️ @acarrer nature.com/articles/s4141…

Dive into our July issue here: nature.com/cdd/volumes/33…

“GCN5 and TADA2B constitutively regulate XRCC1 function during DNA repair to maintain cell survival” This new study reveals GCN5 & TADA2B as guardians keeping repair proteins 'on standby' - first new XRCC1 regulators identified since the 1990s ⤵️ nature.com/articles/s4141…

Macrophage-secreted brain-derived neurotrophic factor promotes tumor growth in triple-negative breast cancer by inducing axonogenesis” BDNF/TRKB axis as a viable #TherapeuticTarget in #TNBC. ⤵️ nature.com/articles/s4141…

“SETD7 depletion enhances white adipose browning and ameliorates metabolic disorders in obese mice” This study positions SETD7 as a novel negative regulator of iWAT thermogenesis ⤵️ nature.com/articles/s4141…

“Species-specific regulation of necroptosis by STK38-dependent RIPK1 phosphorylation” Read how this kinase may serve as a molecular gatekeeper against #TumorProgression by promoting #CellDeath ⤵️ nature.com/articles/s4141…

“Genetic mutations governing ferroptosis sensitivity and resistance: a precision approach to cancer therapy” This review on #Ferroptosis offers insights into #PrecisionOncology strategies to overcome #TherapeuticResistance and enhance clinical outcomes ⤵️ nature.com/articles/s4141…

“TRA2A negatively regulates HIV-1-induced macrophage pyroptosis by mediating TXNIP expression in an m6A-dependent manner” A novel mechanism by which TRA2A modulates the NLRP3 #Inflammasome-#Pyroptosis axis and restricts #HIV-1 replication ⤵️ nature.com/articles/s4142…

Importantly, cytotoxic T cells within CIC neighbourhoods and spatial co-occurrence between cancer cells and CSC-like populations were associated with improved patient outcomes. (5/5)

Engulfed cancer and CSC-like cells displayed features of a loser-cell phenotype, including increased apoptosis and reduced proliferation, whereas outer cancer cells showed winner-cell features such as upregulated glycolysis. (4/5)

“Cell engulfment defines spatially distinct competitive metabolic niches associated with clinical outcomes in colorectal cancer” A new research from @ProfJochen's lab is now online in CDD ⤵️ nature.com/articles/s4141… (1/5)