CDD press

“Dual targeting of chemoresistance and ferroptosis in gastric cancer: DDR1/VEGFR2 inhibitor K-13 synergizes with docetaxel from preclinical models to phase Ib/II clinical trial” A promising therapeutic strategy for late-stage GC patients ⤵️ nature.com/articles/s4141…

“Fibroblast-mediated KRAS activation in double-negative prostate cancer” CCL2–FGF–KRAS signalling as a potential therapeutic target for treating AR-independent prostate cancer in late-stage DNPC ⤵️ nature.com/articles/s4141…

“m6A-mediated CABLES1 translation potentiates tumor radioresistance via facilitating nonhomologous end-joining repair” Discover how CABLES1 inhibition may synergize with existing cancer therapies ⤵️ nature.com/articles/s4141…

“USP4 modulates ZBP1 ubiquitination to regulate microglial PANoptosis and functional outcomes following traumatic brain injury” These findings identify USP4 as a promising therapeutic target for TBI treatment ⤵️ nature.com/articles/s4141…

Dive into our May issue here: nature.com/cdd/volumes/33…

“GET3 regulates apoptosis via tail-anchoring of MCL1” This study provides direct experimental evidence that the GET3 pathway is involved in regulating the anti-apoptotic functions of MCL1 ⤵️ nature.com/articles/s4141…

“Transcriptional and ubiquitinative suppression of macrophage CST3 disrupts colonic homeostasis through defective efferocytosis” This study proposes a multimodal model of macrophage-epithelial crosstalk mediated by macrophage-specific CST3 ⤵️ nature.com/articles/s4141…

“The RNA binding protein LIN28A mediates chromatin dynamics during neuronal differentiation” LIN28A’s role in neural development and differentiation extends beyond microRNA biogenesis and mRNA translation ⤵️ nature.com/articles/s4141…

“Trifluoperazine causes mast cell apoptosis through a secretory granule-mediated pathway” Explore how TFP was repurposed to selectively induce MC apoptosis⤵️ nature.com/articles/s4142…

“TGF-β/SMAD4/14-3-3σ/TFEB axis promotes mesenchymal-epithelial transition and inhibits autophagy in colorectal cancer” Learn more about this tumor-suppressive pathway to improve strategies for mCRC prevention and treatment ⤵️ nature.com/articles/s4141…

May is Melanoma and Skin Cancer Awareness Month Perfect timing to explore these updated collections of melanoma-related research papers in CDDIS: nature.com/subjects/melan… and CDDiscovery: nature.com/subjects/melan… #MelanomaResearch #SkinCancerResearch #CancerAwareness

“Nucleoporin TPR integrates MAPK signaling with mitogen-induced transcriptional programs” This study positions the nuclear pore complex as a dynamic signaling hub that integrates extracellular oncogenic cues with nuclear transcriptional output ⤵️ nature.com/articles/s4141…

Dive into our April issue here: nature.com/cdd/volumes/33…

“NINJ1 ubiquitination by TRIM72 protects against plasma membrane rupture and AKI-CKD progression” The TRIM72-NINJ1-HMGB1 axis: a central molecular checkpoint in the transition from acute kidney injury to chronic kidney disease ⤵️ nature.com/articles/s4141…

“Endothelial USP2a-METTL16 loop potentiates IL-6 signaling via m6A-mediated IL-6R stabilization in pulmonary vascular remodeling” Learn more about the molecular mechanisms downstream of IL-6 in pulmonary vascular remodeling ⤵️ nature.com/articles/s4141…

“Pseudo-senescence induced by palbociclib does not sensitise pleural mesothelioma cells to combinations with senolytics” Understanding the type of therapy-induced senescence is essential for predicting the success of senolytic drug combinations ⤵️ nature.com/articles/s4141…

“Emerging roles of tRNA modification-mediated codon-specific translational reprogramming in cancer biology” This review dissects 18 tRNA-modifying enzymes and their role in regulating codon-biased translation in cancer ⤵️ nature.com/articles/s4141…

“Transcriptome analysis of the prefrontal cortex identifies inflammatory genes associated with cognitive impairment in a model of multiple sclerosis” Study from Prof. Sette’s lab identifies potential markers for MS-related CI ⤵️ nature.com/articles/s4142…

“Mitofusin-2 suppresses tumor immune escape through EGFR/STAT3-mediated PD-L1 transcription” Explore this emerging link between mitochondrial dynamics and tumor immune evasion ⤵️ nature.com/articles/s4141…

“Lactylation as a metabolic-epigenetic switch in cancer: dual roles in cell death resistance and therapeutic vulnerability” A fascinating molecular conduit from metabolism to epigenetic and functional reprogramming ⤵️ nature.com/articles/s4141…