
Fraticelli Lab
252 posts

Fraticelli Lab
@FraticelliLab
Quantitative Stem Cell Dynamics lab @IRBBarcelona led by @AlejoFraticelli stem cells | hematopoiesis | lineages | epigenetic memories Account run by students







INTERESTED IN SINGLE-CELL LINEAGE TRACING? New review @NatureRevGenet from the @FraticelliLab. 🎉🎉 nature.com/articles/s4157… With @VictoriaParreno we tried to update the modern manual for genetic tracing and clonal analysis. ENJOY! Read link: rdcu.be/e50gy


🚨 NEW @FraticelliLab PREPRINT JUST WENT LIVE biorxiv.org/content/10.648… Here, we describe PLSTCs, Soluplus-based expansion cultures of primary mouse *Acute Myeloid Leukemia* Stem Cells. And then we use LARRY barcoding to identify drivers of leukemogenicity and drug resistance!



Inheritable 'memory' genes drive #cancer drug tolerance, but their discovery in clinical samples is a major challenge. Our new theory, moving away from Luria-Delbruck, detects them from a *single* scRNA-seq dataset! With #ArchishmanRaju led by @suvranil_1 tinyurl.com/4pef8scy



Presented a poster today at the Lineage tracing EMBO workshop in Sant Feliu de Guíxols🌞 So cool to interact with people from the field! @FraticelliLab @EMBO











