Henrique Borges da Silva

Bonus: yes, we ate seafood there! 😁

Our lab participation at #AAI2026 was a success! Lots of cool interactions at poster sessions, good science everywhere! We had a lovely time in Boston!

Hi everyone, our lab is at #AAI2026 this week! Check out the posters of our trainees Alma Banuelos (#764, Thursday), Angad Beniwal (#781, Friday) and Sam Shao (#210, Thursday)! I’ll also be chairing a couple of sessions in the brand new NextGen Day for undergrads. See you soon!

Just published: Regulatory T-cell Sensing of Extracellular ATP via P2RX7 Promotes Their Accumulation and Suppression and Drives Lung Tumor Growth doi.org/10.1158/2326-6… @HBorgesdaSilva @igorsantiagobr @MayoClinic @MayoCancerCare

Gut L. salivarius and its metabolite indole-3-lactic acid drive anti-PD-1 resistance in ESCC by activating AhR to suppress NF-κB signaling, triggering terminal exhaustion of NKG7⁺CD8⁺ Tpex cells cell.com/cell-host-micr… @cellhostmicrobe 🇨🇳

@biigoes Lembrou de pedir bença pro pai ontem?

Os caras não sabem saber festa, dai veem os outros clubes fazendo e se impressionam.

Controversy alert: Senolytics may harm healthy brains. New study shows that dasatinib + quercetin - currently in clinical trials as senolytics, trigger white matter injury in healthy mice via oligodendrocyte dysfunction and corpus callosum demyelination. pnas.org/doi/abs/10.107…

📢 If you are working at the intersection of #ionchannels and #transporters in #immunity, we invite you to join us and share your research at the only international meeting dedicated to the biology of ion channels and transporters in this field. If you would like to learn how these research areas converge in exciting ways, come and get up to date on the latest findings. We look forward to seeing you at the #CTImmSRC @FASEBorg Conference in #NiagaraFalls! 👉 events.faseb.org/event/7cca57ab…

Anyone that joins Igor’s lab will 💯 succeed! Super awesome opportunity 👇

@igorsantiagobr You’re gonna do great things Igor!!!! We will be sad to see you go but proud of you! 😊

I would also like to thank my mentor @HBorgesdaSilva for preparing me for this over the last 5 years. I can confidently tell new students to join his lab if they want to succeed in science. Thank you!

I am thrilled to announce that my first career development grant was approved and I will be starting my research group in #LungImmunology as a #YoungInvestigator at the University of São Paulo in Brazil. I will begin recruiting people to join my team very soon.

@tangming2005 That’s a huge issue indeed. We love to use ProjectTILs as well, but I think we must create consensus here - piggying back on the big T cell nomenclature consensus paper

Why I think your single-cell cell annotation benchmarking is missing the mark 👇 You trained your model on large of number of cells (millions), and you use your model to annotate a new dataset.

@benjaminback VÉIO DE BISCATE ROSA AMANHÃ kkkkkkkkkkkkkkkkkkkkkkk

@simone_minnie @DelgoffeLab I personally wouldn’t worry too much about putting these cells into a “box”. It’s possible this is part of the continuum of functionality within “terminally” exhausted cells. Tbh I do see TEXTerm cells IFNg+ in my hands and they are lost in my KO system

@DelgoffeLab @HBorgesdaSilva Not proliferative and no TBET or CX3CR1. They look like ‘classic’ terminal by epigenetic signature but have a distinct RNA profile. Figs from my first paper below. D = RNA, I = ATAC

I'm writing another paper about my described "phenotypically" exhausted T cells. I've seen papers recently refer to "effector" TEX. Should we just pick a name and stick to it? Tex_eff seems broad enough. The phenotypes don't perfectly match, but function trumps phenotype?

@simone_minnie 😂😂😂

@HBorgesdaSilva I might go with terminal effector-exhausted and see if the reviewers yell at me about it 😅

@simone_minnie I think the recent nomenclature consensus Nat Rev Immunol paper will help here. Still not a huge fan of their proposed modular nomenclature but they do attempt to create a system

@simone_minnie Terminally exhausted but somewhat effector? 😂👀 to make things more complex, there have been some recent papers from John Wherry and Laura Mackay groups showing that some of these “terminally exhausted cells” have tissue residency characteristics and respond to anti PD1…

I of course want to thank all of the collaborators that made this possible: our departmental and clinician colleagues at @MayoClinic as well as Ronaldo Francisco Jr. from @Harvard for helping us in the big data analyses.

Finally, I was particularly proud of co-leading this with Igor. This was, frankly, originally his idea. I was a bit concerned that this was going to be a distraction for him (it is not his primary project), but it turned out to be a great idea!

Now that the final version is online, I am happy to share our latest paper! @igorsantiagobr , our talented postdoc, led this paper together with myself. Please check it out! Below, a mini tutorial: aacrjournals.org/cancerimmunolr…