Delgoffe Lab

Dearest gentle reader, we are delighted to announce a new story from our lab published in @Nature describing how a meal's systemic metabolic changes are interpreted by your immune system to enhance adaptive immunity. A thread 1/ nature.com/articles/s4158…

Was lucky enough to chair the #CancerImmuno Fusion meeting with buddies @theLundLab and @Joshilabyale. We def achieved our goals: highlighting the next wave of thinkers in cancer immunology (beyond PD-1 therapy), establishing new networks of researchers, and having a bit of fun!

Sorry @NIHDirector_Jay but doing away with a competitive merit-based system is anti-science and antithetical to the American way. Science by politics is not good science. The U.S. science enterprise was the most successful producer of new cures and discoveries in the past 75 years than the past 7500. You are taking us back to the Stone Age when science was decided by the strongest men, not the smartest.

Cyclosporiasis, the parasite causing the current explosive diarrhea outbreak, is at a level 20x higher than its yearly average. This comes just 1 year after the Trump admin removed a cyclospora tracking mandate from the 'Foodborne Disease Active Surveillance Network.'

@BinZhang_NU @pnas @LurieCancer @Cui_Lab Great work! Super interesting!

Excited to see our new paper out @pnas @LurieCancer @Cui_lab This has been a great collaboration with Weiguo Cui team. Sustained A2AR expression and loss paradoxically promote CD8+ T cell exhaustion | PNAS pnas.org/doi/10.1073/pn…

While seeing this upheld was very encouraging, I'll admit the fact that it was a 5-4 ruling was not.

The Supreme Court sided with big business?!?! Shocker.

I’m so proud of having a crew (and community) of such passionate and hard working scientists, but I’m even more proud of our ability to cut loose and have fun too! Allison (arranged the ballgame) and Rachel (arranged the tailgate) get all the credit!

@timisstuck Working on it! Trial is incoming!

@DelgoffeLab oooooo! Congrats and thanks for pointing to this. Seems tricky to distinguish these effects in humans, just because metabolism and circadian rhythms are so deeply interlocked. Immunotherapy dosing first thing after breakfast?

!!! This paper was obviously not the sole piece of evidence for time of day immunotherapy dosing. But it was the strongest (as noted below, a prospective study). I guess circadian changes to the immune system are too variable person to person to easily capture? Other ideas?

Nature Medicine has pulled a controversial paper tying lung cancer survival to PD-1 treatment timing fiercepharma.com/pharma/nature-…

Brought to you by (you guessed it) basic scientific research.

Netanyahu just openly admitted Trump is his bitch. “When I came to President Trump, I told him: "We are going into Iran." I did not ask permission. I simply informed him of our plan.” What a sad day to be an American.

Breaking News: Officials knew the $16.4 million Reflecting Pool renovation was peeling and turning green earlier than they acknowledged. nyti.ms/4aPItop

The HHS needs a shakeup. Now.

A note to my friends who still back Trump: I am not here to dunk on you. I am writing because you have a working brain, and this story insults it. The Lincoln Memorial Reflecting Pool got a $14 million paint job. Shortly thereafter the water turned green and the new “American flag blue” coating started peeling off the bottom in sheets. Trump says vandals did it. He claims, without evidence, that someone took a knife and cut a 300-foot slit, a number that grew to 350 feet while he was still talking. Back on May 4, Trump bragged about that same coating and said, if you had a knife, you could not even cut it, so strong, like powerful rubber. He cannot have it both ways. And the green water? A George Mason scientist tested it and found ordinary, non-toxic algae, the kind that blooms in any shallow sunny pool. To fight it, crews dumped hydrogen peroxide into the water. Hydrogen peroxide is also a paint stripper. That, not sabotage or vandalism, is the obvious reason the paint came off. They wrecked their own paint job, then blamed phantom vandals for it. The lone "vandal" they paraded is a 67-year-old Olympian who touched a flap of paint already peeling on its own. Here is the thing. If they will look you in the eye and lie about something this small, something you can see with your own eyes, ask yourself what else they are lying to you about. Again, you have a working brain. People like Karoline Leavitt are counting on you to stay loyal instead of exercising independent thought. Prove them wrong.

Ladies and gentlemen, we present to you the man defunding scientific research and public education:

WHO MADE THIS!? I’m dying.

HAHAHA the 300 billion in reparations to Iran is real. So much for your DOGE checks. For those keeping score in the home game, Trump cost the country 500 million dollars a day in elevated gas prices, went through 7 years of munitions stockpiles, spent 113 billion dollars, got 15 soldiers killed, 2 billion dollars worth of damage to US military bases, hundreds of billions in damage to Middle Eastern infrastructure (gas fields in Qatar, hotels in Dubai, etc.) and gave a terrorist regime about 1/3 of a trillion dollars....just to return to the status quo of before the war. All because Trump didn't want people to keep asking about Epstein. Art of the Deal! #Winning

Another PSA: the ludicrous $300B reparation package for the war we didn’t need to start to open a strait that was already open could fund the ENTIRE NIH for 9 years. 9 years of scientific innovation, progress, medicines, insights, even just curiosity and understanding. For what?!