Delgoffe Lab

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Delgoffe Lab

Delgoffe Lab

@DelgoffeLab

Cancer Immunometabolism - Professor - Director: Tumor Microenvironment Center - @PittTweet @UPMCHillmanCC - CoFounder:Novasenta - EiC:Immunology - views my own

Pittsburgh, PA Katılım Haziran 2017
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Delgoffe Lab
Delgoffe Lab@DelgoffeLab·
Dearest gentle reader, we are delighted to announce a new story from our lab published in @Nature describing how a meal's systemic metabolic changes are interpreted by your immune system to enhance adaptive immunity. A thread 1/ nature.com/articles/s4158…
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Delgoffe Lab
Delgoffe Lab@DelgoffeLab·
The world is full of odd happenstances. On the same day our paper on postprandial metabolism dropped @Nature, my 1st grad student, Nicole, published her postdoc paper at @CellCellPress! An incredible tour de force studying proteostasis in T cell exhaustion cell.com/cell/fulltext/…
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Delgoffe Lab
Delgoffe Lab@DelgoffeLab·
@RoychoudhuriLab Thanks! So, we thought this. And, if after all of the murkiness of that RCT is worked out and it ends up being solidly true, we think this could be a mechanism!
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Roychoudhuri Lab
Roychoudhuri Lab@RoychoudhuriLab·
Congratulations on some fantastic work Greg et al! Do these findings help explain data from observational and recently a randomised control study suggesting that the time of infusion affects the efficacy of checkpoint inhibitor immunotherapy with anti-PD1 antibodies?
Delgoffe Lab@DelgoffeLab

Dearest gentle reader, we are delighted to announce a new story from our lab published in @Nature describing how a meal's systemic metabolic changes are interpreted by your immune system to enhance adaptive immunity. A thread 1/ nature.com/articles/s4158…

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Delgoffe Lab retweetledi
Kiran Mazumdar-Shaw
Kiran Mazumdar-Shaw@kiranshaw·
Can diet shape immunity? At University of Pittsburgh, Greg Delgoffe and team show T cells respond better after meals, likely boosted by higher protein production for faster activation. The experiment may pave way for better CAR T-cell therapy as engineered T-cells fight much effectively. nature.com/articles/d4158…
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Delgoffe Lab
Delgoffe Lab@DelgoffeLab·
@Iris_Illera @Nature So we did this in people - remaining fasting or coming in fed to control for time of day. However, we haven't done the circadian biology alterations in mice.
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Yirees Szyłowicz
Yirees Szyłowicz@Iris_Illera·
@DelgoffeLab @Nature I do feel like the circadian rhythm alteration experiment would have been a good control to avoid possible modulation by light-sensing and such. After recent discoveries of opsins in keratinocytes you never know!
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Delgoffe Lab
Delgoffe Lab@DelgoffeLab·
Dearest gentle reader, we are delighted to announce a new story from our lab published in @Nature describing how a meal's systemic metabolic changes are interpreted by your immune system to enhance adaptive immunity. A thread 1/ nature.com/articles/s4158…
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8
81
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Delgoffe Lab
Delgoffe Lab@DelgoffeLab·
Thanks for a great writeup (and fun photo session) from @pitt_immunology on our latest work in @Nature describing how a meal can improve T cell metabolism and function!
Pitt Department of Immunology@pitt_immunology

Feed your T cells! A new @Nature paper from @DelgoffeLab shows that T cells collected after a meal are more potent than those from fasted individuals, suggesting potential for diet-based strategies to improve cancer immunotherapy & vaccine responses. immunology.pitt.edu/news/eating-bi…

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Delgoffe Lab
Delgoffe Lab@DelgoffeLab·
This was a massive team effort led by a phenomenal postdoc, Alok Kumar, and prior fellow, Dayana Rivadeneira. The whole lab contributed, as well as several amazing collaborators at @PittTweet, @UPMCHillmanCC, @PittHealthSci. 18/
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Keşfet

@MagarianBlander @Nature @CellCellPress @RoychoudhuriLab @sciam @PGTimmune @Iris_Illera @pitt_immunology