Ion Channels @Leeds

Upcoming Webinar - Tuesday 29th June at 14.00 BST @DrJonLippiat will talk about the discovery of KNa1.1 (KCNT1, SLACK, Slo2.2) channel inhibitors using virtual screening and CryoEM structures. If interested, register here: lnkd.in/e4QmeHA #ionchannels @Metrion_Biosci

Any channel-lovers looking for a job? We have a postdoc position available on a project to characterise our next set of novel KCNT1 potassium channel inhibitors. Deadline 28 April. #KCNT1 #ionchannels #epilepsy jobs.leeds.ac.uk/vacancy.aspx?r…

In our new RSC review we accumulated DEER/PELDOR studies of membrane proteins over 15 years ABC/Multidrug/Secondary transporters, to GPCRs, SEC transloc, Photosynth. & Mitochondr, OMPs, ion channels et al, combined with multiple lipid mimics and MD tools : pubs.rsc.org/en/content/cha…

Proud that our work on understanding small-molecule modulation of #TRPC channels by #CryoEM has now been published in @CommsBio. Great work driven by @scidave with @chmkjs @RachelJ9908 @profdbeech @stemuench from @UoL_LICAMM @AstburyCentre @Astbury_BSL. rdcu.be/cbbn1

Another collaboration between Leeds ion channel and virology groups.

Delighted to share our latest work published today in @CellReports on how intrinsically rapidly-inactivated PIEZO1 channels sense sustained mechanical force such as blood flow in endothelium. Thanks to our team in @unileedscardio and Toulouse. cell.com/cell-reports/f…

Patch-clamp: Long shot; anyone know a patcher in the Liverpool area up for some short term/part time single-channel WORK on a great but easy project!? Even PhD student as part-time casual OK if can patch!! #ionchannels @Channelomics @RainbowLabUoL @ClaireMemimo @david_colquhoun

@Bela_Bode @mayue3691 @LeedsIMB @IonChannelLeeds @AstburyCentre @ScienceLeeds @EPR_ESR @Channelomics

Please to announce my first first author paper is out now in Antiviral Research! Looking at the role of ion channels during the entry of the polyomaviruses SV40 and MCPyV sciencedirect.com/science/articl…

Local Ca2+ signals couple activation of TRPV1 and ANO1 sensory ion channels stke.sciencemag.org/content/13/629…

It's published! #ionchannels #kcnt1 #epilepsy @Beth_aimee_cole @RachelJ9908 @jeff_dddd @FishwickGroup @stemuench

I am delighted to join the editorial board of The Journal of Physiology (the most prestigious and leading journal on physiology since 1878) as an editorial board fellow. Look forward to working with you @JPhysiol to serve the whole community.

Very proud to share the first #CryoEM studies by our @UoL_LICAMM @AstburyCentre #TRPC team: Cryo-EM structures of human TRPC5 reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site. biorxiv.org/content/10.110…

We're delighted that @RohacsTibor is visiting us today. He will be delivering his seminar on "Regulation of TRPM Channels by G-proteins and phosphoinositides" at 2pm in RSLT23.

New #ionchannels publication from Leeds researchers @PliotasGroup and @DrJonLippiat featuring PELDOR/DEER spectroscopy and patch clamp of reconstituted mechanosensitive channels.

New research posted as a #preprint from our Ion Channel and Membrane Protein structural biology teams @LeedsIMB

#PLOSCompBio: Arrhythmia mechanisms and spontaneous calcium release: Bi-directional coupling between re-entra ... dx.plos.org/10.1371/journa…

#PLOSNTDs: Chikungunya virus requires cellular chloride channels for efficient genome replication dx.plos.org/10.1371/journa…

A Mechanism for Statin-Induced Susceptibility to Myopathy sciencedirect.com/science/articl…

A cytoplasmic Slo3 isoform is expressed in somatic tissues @drjonlippiat rdcu.be/bQWLe