Kyle Mentkowski

I couldn’t be happier with the decision to join @MatthiasNahrend lab at Massachusetts General Hospital and @harvardmed. Thanks to the @EMBO Postdoctoral Fellowship for the support! More about electroimmunology to come! 🫀⚡️👩🏻‍🔬

Research | Yamazoe et al. show that B-cell derived autoantibodies contribute to the development of atrial fibrillation, suggesting that targeting the humoral immune response may represent a viable therapeutic approach. doi.org/10.1038/s44161… rdcu.be/eNFJV

Fresh in @NatureCVR 👇 rdcu.be/eJ2Ez A work of ❤️‍🔥 by Masahiro & friends shows how autoantibodies lead to atrial fibrillation. This has translational potential as B cell depletion is established clinically. Need to find out which patients make those bad antibodies!

Resistin-like molecule γ attacks cardiomyocyte membranes and promotes ventricular tachycardia | Science science.org/doi/10.1126/sc…

Great catching up with the Lang Lab at AHA! 🫀

Congrats to our semifinalists for the #CVRC2024 retreat oral abstract prize, Greg Gipson @adamjohnsonmd @KyleMentkowskil and Rashmi Richa—Kyle with top honors! A bright future for these talented young scientists. Mentors: @MatthiasNahrend @MarkELindsay @Raj_MalhotraMD @bmprii

A new article on EV engineering from the Lang Lab is out now in FASEB! A huge thank you to Touba and Lisa who took this research across the finish line 🎉 Read more here: faseb.onlinelibrary.wiley.com/doi/10.1096/fj…

Sharing the translational followup to Maarten's AF paper last year. We introduce a drug candidate for atrial fibrillation ❤️❤️‍🔥⚡️ Awesome team effort! Therapeutic Spp1 silencing in TREM2+ cardiac macrophages suppresses atrial fibrillation biorxiv.org/content/10.110…

For a joint project with Peter Libby on myocarditis, we are looking for a postdoctoral fellow with immunology background. Please email me if interested❤️‍🔥

🚨My PhD work is out in @JACCJournals !! Using a translational approach, we highlighted the importance of MCP-1 and IL-6 and their role in macrophage recruitment and polarization! 🫀 jacc.org/doi/10.1016/j.…

How severe Covid leads to myocarditis without virus in the heart: the role of activated heart macrophages ahajournals.org/doi/10.1161/CI… @JanaGrune @ChariteBerlin @MatthiasNahrend @MGH_RI and colleagues

Massive, international effort to update the basic guidelines on EV research. Congrats @KennethWWitwer, @IsevOrg, and all authors! Proud to have contributed to the #MISEVconsortium

We have open postdoc positions in our lab at the @HMSGenetics department! Are you interested in somatic evolution? Do you want to work in an exciting, collaborative environment at the heart of the HMS campus ? Enjoy a rich academic culture and friendly colleagues? More 👇

Look what's under the tree: #MISEV2023 has been accepted for publication! This third iteration of the international consensus guidelines on minimal information for studies of #ExtracellularVesicles is brought to you by @Joadwe @lodrisc1 @GoberdhanD & Clotilde Théry, plus the #ISEV board and the whole, amazing EV community! What you can expect from the new #MISEV: Nomenclature: communication of concepts and new info on #NVEPs (non-vesicular extracellular particles) Collection and pre-processing. Pre-analytical variables for EV sources including bacteria, biofluids, tissue EV separation and concentration EV characterization Technique-specific reporting for EV characterization EV release and uptake Functional studies In vivo EV studies @IsevOrg @IsevComms @ISEV_Journals #JEV @EditBuzas @cblenkie @doldivizio @tomdriedonks @erdbruegger @Exosome_UPLC_MS @hillandy @LenassiMetka @SusmitaSahooPhD @AnaTorrecilhas @SNEVresearch and many more

🤔Wonder what’s going on in your bone marrow after MI ? 🫀🦴 Have a look at our new paper in @NatureCVR! rdcu.be/dsN4e Perfect illustration of team work! Special thanks to @MatthiasNahrend for this opportunity to close the chapter!

Meet the longest lasting project of the lab⏳ 🦴 marrow fat cells provide local fuel for hematopoietic stem cells after MI 🔥 rdcu.be/dsN4e Very happy that it is now out in @NatureCVR ❤️ Thank you fellows and collaborators for hanging in there on this journey!

We are of course hiring! If you are interested in somatic evolution (normal tissue evolution, carcinogenesis, metastasis development) *in humans*, please reach out. New lab website is on the way and only delayed by my personal slowness. Old website in bio still accurate though.

Coordinating people and outfits for today’s big experiment! @KyleMentkowski @PabelSteffen @MaartenHulsmans @noor_M0MIN @MatthiasNahrend

Macrophages mess with ❤️ rhythm ⚡️ transcriptomics and protein data describe 3-fold expansion of these leukocytes in patients with atrial fibrillation. Among the top expressed genes: osteopontin (SPP1), catalyzing atrial fibrosis and inflammation ❤️‍🔥 science.org/doi/10.1126/sc…