Nature Cardiovascular Research

❤️Our March issue is out❤️Read about an AI model using echocardiography images improves cardiac diagnosis, LVAD unloading alleviates cellular senescence, inhibition of a hematopoietic death regulator shows cardioprotection, and more. nature.com/natcardiovascr…

❤️Our February issue is out❤️Read about self-powered stent for real-time monitoring, cardiomyocyte regeneration through glucocorticoid receptor antagonism, immunometabolic targeting for type 2 diabetic cardiomyopathy, and more. nature.com/natcardiovascr…

Research | Lazarevic et al. reveal a shared loss of a TBX5-dependent atrial gene network in cardiomyocytes and a disease-specific network gain in activated fibroblasts across atrial fibrillation and heart failure models. nature.com/articles/s4416…

Research | Chen et al. developed a self-powered smart magnetoelastic stent for real-time hemodynamic monitoring and stenosis detection. nature.com/articles/s4416…

Research | Da Pra et al. show physiological glucocorticoids suppress GF-induced CM regeneration by inhibiting ERK signaling and propose glucocorticoid receptor antagonism as a strategy to enhance their regenerative effects. nature.com/articles/s4416… rdcu.be/e2Fa9

❤️Our January issue is out❤️Read about pathogenic mechanism of mutated ribosomal protein PRL3L, identification of cardiac progenitor lineage linked to congenital heart disease, multimodal vision graph for drug repurposing, and more. nature.com/natcardiovascr…

Research | Kathiriya et al identify a cardiac Tbx5+/Mef2cAHF+progenitor lineage that bisects the intraventricular septum during the development and show that alterations in this lineage lead to congenital heart disease. nature.com/articles/s4416… rdcu.be/eZGiu

Big thanks to the Science Ministry of Serbia, Drs. Knoblich, Guilliatt, Stewart, & Turco, and Profs. Radisic, Hedtrich, Clevers, Vunjak-Novakovic, Trayanova, Lütolf, Heilshorn, Dvir, Cho & Singh for the great event! @milicaruoft @GVNlab @TheCleversLab youtube.com/watch?v=4wmna0…

❤️Our December issue is out❤️Read about a method to measure mitochondrial membrane potential in intact hearts, gene therapy for myocardial infarction, genetic association between thromboembolism and long COVID, and more. nature.com/natcardiovascr…

Research | Neo et al. map blood emergence from three hemogenic endothelial (HE) populations biased toward distinct blood fates. HE primed for stem progenitors shows elevated chromatin and RNA splicing gene expression. doi.org/10.1038/s44161… rdcu.be/eQxPN

❤️Our November issue is out❤️Read about an imaging method that combines cardiac electrophysiology with 3D structural heart reconstruction, a targeted glycophagy ATG8 therapy reversing diabetic heart disease, and more. nature.com/natcardiovascr…

Research | Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage-fibroblast interactions that control late-stage fibrosis. doi.org/10.1038/s44161… rdcu.be/ePzs6

Research | Chen, Wang, Zhong and colleagues show that females derive greater cardiovascular benefits from guideline-recommended levels of physical activity and require less activity than males to see their beneficial effects. doi.org/10.1038/s44161… rdcu.be/ePoLS

Research | Tan et al. identify PRDM16 as a key repressor of fibrotic switching in smooth muscle cells and show that its downregulation in atherosclerosis drives smooth muscle cells toward a synthetic fate, promoting fibrous plaques. doi.org/10.1038/s44161… rdcu.be/eOBP0

Research | Lin, Geng et al. identify a non-canonical AHR pathway that is activated by canonical AHR inhibitors, promoting the proliferation of quiescent endothelial cells with potential applications in cell therapy. doi.org/10.1038/s44161… rdcu.be/eOoxB

Research | Amiad Pavlov, Heffler et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic target. doi.org/10.1038/s44161… rdcu.be/eOeTA

Research | Yamazoe et al. show that B-cell derived autoantibodies contribute to the development of atrial fibrillation, suggesting that targeting the humoral immune response may represent a viable therapeutic approach. doi.org/10.1038/s44161… rdcu.be/eNFJV

Research | Mulholland et al. identify progenitor exhausted T cells, expressing intermediate levels of PD-1, as a prominent source of pro-inflammatory cytokines in the murine atherosclerotic aorta and potential cellular targets. doi.org/10.1038/s44161… rdcu.be/eL2nN

❤️Our October issue is out❤️Read about the RNA editing enzyme ADAR1 regulating atherosclerosis progression, PGC-1α and cardiac adaptation to exercise training, the role of LYVE1-macrophages in heart regeneration and peripheral artery disease, and more. nature.com/natcardiovascr…

Research | Barbera et al. identify and map genetic variants that alter the characteristics of vascular smooth muscle cells and contribute to the risk of coronary artery disease. doi.org/10.1038/s44161… rdcu.be/eKY2S