Moraga Lab
100 posts
Moraga Lab
@LabMoraga
The Moraga group studies cytokines and their central role in immune regulation. We combine protein engineering, structural biology & immunology in our research
University of Dundee Beigetreten Mayıs 2019
139 Folgt147 Follower
Very humbled to receive this long-term funding! Thank you to past and present lab members, collaborators, and funders for making this possible!
Dunn_School (now @DunnSchool.bsky.social)@Dunn_School
Congratulations Ivan and Omer! 👏👏👏 The @IvanAhelLab and @Dushek labs have been awarded prestigious @wellcometrust Discovery Awards programme grants! Find out more: path.ox.ac.uk/news-article/t…
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After a hard year, I’m glad to see this finally over the line. A real team effort from @YiboJin @scott_d_gardner @TomasVoisin and others from @LabMoraga. As always, amazing data collection support @eBIC_Diamond #cryoem nature.com/articles/s4146…
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Disease-associated variant in IL6ST gene encoding for gp130 led to increased flexibility including motion within the cytokine-binding core (IL-6 and IL-11) and increased distance between extracellular domains
nature.com/articles/s4146…
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Excited to share our newest full collaboration with @BubeckLab. We provide structural insights that help explain how mutations in gp130 that do not disrupt cytokine binding cause signaling defects and immunodeficiencies in humans. doi.org/10.1038/s41467…, @UoDCellSigImm
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Happy to share the good news of promotion to professor. Thanks to all lab members past and present, generosity of @CR_UK @ERC_Research @wellcometrust and support of amazing colleagues @ImperialSci @imperialcollege. I couldn’t have done it without you.
Imperial Life Sciences@ImperialLifeSci
Many congratulations to all academic staff who were promoted this year! A wonderful achievement 👋😃 imperial.ac.uk/news/247435/li…
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🚨2 Yr Postdoc Available🚨
Jointly supervised with @scienceadvocacy working on normal and pathological HSCs, cytokines, malignancy, clonal expansion. Come and join us at the newly-formed @CBR_UoY @YBRI_UoY
Apply here 👇👇👇jobs.york.ac.uk/vacancy/post-d…
Pls retweet and DM!
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Differential functional coupling in Gp130-JAK complexes expands the plasticity of the interleukin-6 signaling axis biorxiv.org/cgi/content/sh… #bioRxiv
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Ever wonder why ancestral cytokine receptors, like Gp130, bind multiple JAKs, and whether the identity of the GP130-JAK complex instructs specific responses? Check our new work, in a full collaboration with the @PiehlerLab, for some answers
biorxiv.org/cgi/content/sh…
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📜State-of-the-Art📜
Molecular and cellular factors determining the functional pleiotropy of cytokines
🖋️ By Alison McFarlane, Elizabeth Pohler and Ignacio Moraga from @dundeeuni
🔗 buff.ly/3pWOAme
#cytokinesignalling #endosomessignalling
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So excited for this session, I couldn’t sleep! Cytokines, engineering, structures, and therapies.
Not a session to miss!
10:15 AM-12:15 PM room 102AB
ChrisHunter@KingOfPathogens
Attending @ImmunologyAAI this week and love cytokines? @CytokineSociety: Modulating Cytokine Activity through Structural Knowledge – Saturday; 10:15 AM – 12:15 PM; Room 102AB. Organized by @DrJuanLMendoza with lots of cool cytokine engineering @SpanglerLab @Regeneron
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Thank you, Leslie and everyone at HHMI. I can’t express how grateful I am to be part of this outstanding group of scientists. With the support of HHMI, we can focus on our science but also make an impact in mentoring to lift us all up. Congrats to all the FHScholars!
Leslie Vosshall PhD@leslievosshall
Here they are!!! 31 outstanding scientists who as early career faculty with exceptional mentoring skills will build inclusive and supportive labs where all trainees thrive and persist #FHScholars
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Interested in interleukin-6 and how you can therapeutically block its pro-inflammatory activities? See our latest review, just published in @NatRevImmunol — great team work together with @Lab_Jenkins, Stefan Rose-John @kieluni and Jens Moll/Jürgen Scheller @HHU_de
Nature Rev Immunol@NatRevImmunol
Targeting IL-6 trans-signalling: past, present and future prospects dlvr.it/SmdK7P
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@FranInesta ni sabia que habia esa conferencia, la primera noticia que tengo, a ver cuando me invitais? Salgo barato mi hermano esta en badajoz, asique no necesito alojamiento!
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Cita imprescindible, con ponentes de primera línea que incluyen al Profesor Philip Cohen (@mrcppu, una de las colaboraciones publico-privadas más exitosas de la biotecnología en Europa)
Francisco Centeno Velázquez@PacoCenteno
Del 12 al 14 de julio, en #Badajoz, tendremos el XVI Congreso Anual de #Biotecnología @bac_febiotec Organizado por @biotextremadura y @febiotec. #Biotecnólogos #Biólogos #Bioquímicos y demás #Bios, hay que ir. Información e inscripción bac.febiotec.es Pasaré lista.
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Join us for the ICIS-sponsored and organized session at Immunity 2023! Learn how both academic and industry members of ICIS are advancing our understanding of cytokine biology and developing future immunotherapeutics.
ICIS 🦋 @cytokinesociety.bsky.social@CytokineSociety
Going to AAI? Please join us for the ICIS Guest Symposium "Understanding and Modulating Cytokine Activity through Structural Knowledge" @DrJuanLMendoza Saturday, May 13; 10:15 AM – 12:15 PM Eastern Time in Room 102AB cytokinesociety.org/understanding-… via @httpstwittercomCytokineSociety
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Moraga Lab retweetet
Going to AAI? Please join us for the ICIS Guest Symposium "Understanding and Modulating Cytokine Activity through Structural Knowledge" @DrJuanLMendoza Saturday, May 13; 10:15 AM – 12:15 PM Eastern Time in Room 102AB
cytokinesociety.org/understanding-… via @httpstwittercomCytokineSociety
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NEW for 2023 on the @SciImmunology website is the dedicated CANCER IMMUNOLOGY block.
🔗➡️bit.ly/Cancer_Immuno
Scroll down to it & check out 6 recent #cancerimmunology papers. More exciting new content is on the way to this space soon!
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#Cancer
L’acidité des tumeurs nuit à l’efficacité des thérapies anticancéreuses, selon une nouvelle étude. Des résultats qui pourraient conduire à une nouvelle génération de traitements d’immunothérapie.
➡️bit.ly/3hLyjNq
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Moraga Lab retweetet
SPOTLIGHT: After showing that tumor-derived lactic acid limited IL-2 signaling, STAT5 phosphorylation, and antitumor activity in the TME, @Inserm @at_Mitralab used directed evolution to identify a pH-selective IL-2 mutein that bound IL-2Rα with [...] 👉 ow.ly/QAse50M3ptF
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