Laura Depta

Pleased to announce that the open access version of our review "Structure, function and small molecule modulation of intracellular sterol transport proteins" is out now as part of Herbert Waldmann Honour Issue in Bioorg. Med. Chem. Check it out!🤩 doi.org/10.1016/j.bmc.…

Check out our new paper in J Med Chem @ACSBioMed on the synthesis diverse alkaloid-inspired compounds leading to the identification of 5-HT2A agonists and dual 5-HT2B/C antagonists! Big congratulations to Ruwei! @ChemistryDtu 1/n pubs.acs.org/doi/full/10.10…

My first preprint is out now! We targeted squalene synthase, an important enzyme for #cholesterol biosynthesis and identified small molecule degraders and stabilizers. Grateful for guidance by @laraialab 🙏 big thanks to Cecilia, @Laura_dta, @ERADLab and Mesut!

We are using organoid-based disease models to discover new chemical tool compounds to study metabolism in cancer and the gut. These "mini-organs" closely resemble the human organ/disease and allow us to study the disease-relevant chemical space. 1/2

New preprint! We discovered degraders and stabilizers of the #cholesterol biosynthesis enzyme squalene synthase, based on the same scaffold! Great work by PhD student @HoockJoseph, with support from Cecilia, @Laura_dta and collaborators Mesut and @ERADLab! biorxiv.org/content/10.110…

I’m very proud and honoured to announce that I have been selected as a recipient of the Fulbright scholarship to support my external research stay at Rice University in Assoc. Prof. Hans Renata’s research group. A huge thanks to @FulbrightPrgrm and to @hanzyduzit for hosting me!

By building a sterol transport protein (STP) screening set, we identified OSBP as the target of our compounds. They are selective over ORP4, as well as over all tested STPs! The compounds led to inhibition of retrograde trafficking and attenuated shiga toxin toxicity! /fin

New preprint! We discovered potent and selective OSBP inhibitors which inhibit retrograde trafficking by causing partial Golgi degradation. Great work by Nianzhe, @Laura_dta, Cecilia, Oliver and @HoockJoseph from our lab! 1/ biorxiv.org/content/10.110…

We have two open #Postdoc positions in #ProteinExpression and #Structuralbiology at the @TU_Dortmund ! More information here: rauh-lab.de/news-events-re…

It was a pleasure to play a part in this cool paper by @MarkoCigler @georg_e_winter et al! Great work from @Laura_dta in our lab who developed an FP assay to determine inhibition of OSBP and ORPs! Watch this space for another joint paper coming very soon!

Thrilled for our Orpinolide story to see the light of day! Huge thanks to the @georg_e_winter lab, Waldmann lab, @laraialab and everyone that contributed @HanaImrichova, @FabianFrommelt, @Laura_dta, Andrea, @CKagiou, Thomas, @CrisMayorRuiz, @gsf_lab and Sonja Sievers! 🧵👇

Yesterday we said goodbye to Hannah and Sara, our visiting trainees from @mpimoph. Thanks for joining us and all the hard work!

A new paper from @kevansf and @bignerdzzy identified a strained β-lactone electrophile that covalently targets a KRAS G12 somatic 2 mutation and acylates the mutant serine to suppress oncogenic signaling.

Mechanism of threonine ADP-ribosylation of F-actin by a Tc #toxin - collaborative work by @Intein & Oschkinat @LeibnizFMP & @BardiauxB @institutpasteur & Bieling @mpimoph #cryoEM 🔗 #NMR published in @NatureComms #actin nature.com/articles/s4146…

never forget the scale bar! @StearnsLab when biology meets astronomy: cell vs nebula, centrosome vs dying star! @EtienneKlein

New @ERC_Research funded postdoc position in mass spectrometry-based #proteomics in our lab @ChemistryDtu, looking to develop target identification and engagement strategies for modulators of cholesterol homeostasis! Please RT #postdocjobs kemi.dtu.dk/omos/jobliste/…

New #PhDposition in #medchem #chemicalbiology our lab! The project is related to the study and targeting of sterol transport proteins using chemical tools, funded by @ERC_Research. RT appreciated! @ChemistryDtu kemi.dtu.dk/omos/jobliste/…

Check out our new paper on mapping the #oxysterol interactome using thermal proteome profiling, now out in @ACSBioMed ACS Chem Biol! Great work by our fantastic postdoc Cecilia! #lipidtime pubs.acs.org/doi/full/10.10…

Good morning, everyone! Wishing you a day full of productivity ...and #coffee! 😁*We don't know about you, but we feel straight lines are overrated anyway! 😉🤗☕️ ☕️☕️☕️😁* [Cartoon by @ErrantScience = @MCeeP & @MichelleAReeve]

@TzuChen_Lin @spalei Congratulations! 😊

Hello (scientific) world (of Twitter)! First step into the academic world of social media with my first first-author publication on ACSchembiol, with the support of my excellent coworker @spalei and my fantastic supervisor Daniel Summerer. pubs.acs.org/doi/10.1021/ac…