Lazzara Lab

A new @SciSignal study identifies enzymes that may drive a drug-resistant state in #PancreaticCancer and decrypts tumor heterogeneity at the single-cell level, suggesting that drugs called ERK inhibitors could minimize resistance to chemotherapy. scim.ag/3JbNPzD

Applying single-cell imaging and mutual information concepts, researchers discover that the activity of the kinase ERK drives EMT heterogeneity in #PancreaticCancer cells in response to growth factors or chemotherapeutics. @LazzaraLab @UVA scim.ag/45jxAcd

You can register as a virtual attendee here web.cvent.com/event/00434ed6…

Check out a new preprint from the lab -- "Hypoxia-induced histone methylation and NF-κB activation in pancreas cancer fibroblasts promote EMT-supportive growth factor secretion." biorxiv.org/content/10.110…

Q&A: What Should You Know About the Forever Chemicals We All Ingest? Interview with my fellow UVA ChE Professor Bryan Berger @BergerLabUVA. news.virginia.edu/content/qa-wha…

New comprehensive review of cancer systems biology from the co-directors @janeslab and @LazzaraLab of the SASCO center @NCIsysbio and @UVAEngineers: annualreviews.org/content/journa… Final version will appear in May.

Excited to share this video introduction to cancer systems biology: youtube.com/watch?v=rmuj1c… (Abridged versions for those with short attention spans: youtube.com/watch?v=Cp9tar… youtube.com/watch?v=C3iXBM…) Thank you to our SASCO Education Scholar, Sarah Groves!

Today is the final day to submit an abstract for the 2025 Systems Approaches to Cancer Biology Meeting -- February 10-12, University of Colorado, Anschutz Medical Campus. Registration and abstract submission can be done here -- sacbmeeting.org

UVA’s Center for Systems Analysis of Stress-Adapted Cancer Organelles just had its first symposium!🧫🔬 Highlights included work targeting breast, colon and brain cancers, pursuit of equitable research, and a keynote by @bradylabupenn. Read more: bit.ly/3SZCwwu

The special issue of @CR_AACR is now online for #AACRPan24. Here are some of the “cancer research landmarks” articles on #PancreaticCancer: (1) Cancer research landmarks on cancer associated fibroblasts (CAFs), by @BiffiGiulia & colleagues aacrjournals.org/cancerres/arti… (2) Cancer research landmarks on BRCA2 and pancreatic cancer, by @JonBrodyPhD & @alisonpklein aacrjournals.org/cancerres/arti… (3) Cancer research landmarks on the role of an immune suppressive microenvironment in early disease driving pancreatic cancer progression, by @Fil_Bednar @Pasca_Lab aacrjournals.org/cancerres/arti… (4) Cancer research landmarks on nutrient levels and nutrient sources in pancreatic cancer, by @WilhelmPalm aacrjournals.org/cancerres/arti…

New lab logo, design by PhD student Michelle Barbeau!

Interested in a PhD in Chemical Engineering? At UVA, we've got leading research programs in catalysis, biomaterials, separations, simulations, and more! Come talk to us at one of our virtual info sessions: 9/18: 8-9am 10/1: 7-8pm 10/17: 8-9am 👇Check out below for details!

The 4th Michael J. Weber Symposium is almost here! The event will bring together leading researchers and clinicians on Oct. 11 to present findings on timely areas of cancer research. This year’s theme is “RNA and Cancer.” Click below to register: bit.ly/3YJygot

Congrats to all for a successful SASCO symposium and @NCIsysbio site visit! news.med.virginia.edu/research/first… The Hot Ones career advising panel was a terrific success (thanks to Iylan from @sepiddsh lab and Jen from @kashatuslab for participating).

The 2025 SACB Meeting will be a great conference opportunity for cancer systems biology research -- Colorado, Feb 10-12, sacbmeeting.org. Hope to see you there!

@SascoVirginia holds its inaugural Symposium on July 23 at @MedicineUVA with research presentations, a career panel, and a keynote by @bradylabupenn! Registration is required and includes meals and a social. Register here: virginia.box.com/s/ew7vklsplu05…

Check out our recent paper in Cancer Research -- A Histone Methylation–MAPK Signaling Axis Drives Durable Epithelial–Mesenchymal Transition in Hypoxic Pancreatic Cancer. Thanks to collaborators @PitarresiLab, @BenStanger01, and many others. aacrjournals.org/cancerres/arti…

Congratulations to Logan Campbell for the successful defense of his BME MS thesis yesterday! Logan presented his outstanding work on the design of kinase-stabilized suicide gene therapies for cancer. @UVABME

Great showing by the lab at the Commonwealth of Virginia Cancer Research Conference yesterday at UVA Darden. Thanks to Sarah Lee, Sarah Buchanan, Michelle Barbeau, and Karl Kowalewski for presenting such nice talks!

@PamKreeger Same. Hope you are well!

Lazzara Lab BMES 2023 — Congrats to REU student Amanda Pearson for her outstanding presentation on KRas inhibitors in pancreas cancer! Congrats to postdoc Varghese Kurian and PhD student Michelle Barbeau for the presentation of their work on process control models of EMT!