Ried

@abbydabby55555 Yoooooo whaaaat?!??

i'm a femme twink with masc feet

@abbydabby55555 Wait, whattt

if ur seeing this youre gay

Life is magical

Chomp pizza in Chicago will blow your balls off @stoolpresidente

@abbydabby55555 @benchedrunner what is Abby referencing?!??

@abbydabby55555 Bahahahahaha

COMPUTAH!!!!

does anyone else feel like they need an everything shower after eating barbecue chips

Nothing like curling your hair every morning, so people think you have natural curls. #amiright @abbydabby55555

@DannyLuan6 @RShouval @KRejeski lol

Finally published in print! Time of day of CAR T-cell infusion and outcomes in large B-cell lymphoma @RShouval @KRejeski ashpublications.org/blood/article/…

@Ronalfa @satyanadella @NOETIK_ai That’s neat. If only there was a way to validate your model…

That's neat @satyanadella but we’ve trained a multimodal AI model to turn pathology into the whole spatial transcriptome. @NOETIK_ai

@MichaelDJain @RahulBanerjeeMD @Myeloma_Doc Bachem et al 2019 and 2025 immunity.

@Myeloma_Doc It’s always a chicken and egg problem. Are antibiotics needed because T cells are bad, or are T cells bad from the antibiotics/microbiome? I suspect the former. ashpublications.org/blood/article/…

#Myeloma Paper of the Day: Broad-spectrum antibiotics prior to T-cell engagers associated w/ significantly inferior 1-year OS (60 vs 77%) & PFS (26 vs 53%) & higher relapse incidence; microbiota composition correlated w/ therapy response & toxicity: pubmed.ncbi.nlm.nih.gov/41791791/. #mmsm

@AnilMakam If there is no fraud, why retract? What other study requires external verification?

11/ None of this proves errant findings or fraud "When the only knob you turn is the clock and survival doubles, extraordinary claims don’t earn applause, they earn scrutiny" Hence, retract until verified

1/ A recent trial claims that giving immunotherapy before 3pm doubles survival in advanced lung cancer Extraordinary claims deserve extraordinary evidence When paired with multiple red flags, it raises the possibility that the findings are unreliable or worse, fabricated. 🧵

@AnilMakam So? That’s the point of the study.

7/ 🚩#4 Infusion times are odd They cluster 9–12:30, then 3–6:30 With a 3-hour gap in between That’s not random timing around a 3pm cutoff That looks like two clinic sessions

@AnilMakam This could be explained by completing enrollment >12 months prior to data analysis.

5/ 🚩#2 No censoring in the first 12 months of survival analysis! Trials are inherently messy A perfectly “clean” year is unusual

“I” just wrote a 100 page IND today. I don’t know how people survived before Claude.

@JCO_ASCO I just read the first sentence and am utterly confused.

Noncomparative Comparisons: The Paradox of Randomized Noncomparative Trials. Read the full article. brnw.ch/21wYEDo

It’s grind o’clock. LFG. #lactulose #performanceEnhancer

@RahulBanerjeeMD @szusmani Why not just put the two constructs in the same T cell instead?

#IMS25 return of the CARpools! @szusmani presenting on #shammailankody’s behalf - combining two CARs, one for BCMA and one for GPRC5D (JCARH125 lives on!) One challenge (maybe?) is that one rapidly expanding CAR can inhibit the other… looking forward to more follow-up!

Jacob collier is really cool