Ron Alfa

3.9K posts

Ron Alfa

@Ronalfa

CEO & Co-founder @NOETIK_AI | Using AI to actually solve cancer. Ex-@RecursionPharma | Stanford MD-PhD

San Francisco, CA Katılım Şubat 2011

2.6K Takip Edilen7.1K Takipçiler

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Ron Alfa@Ronalfa·18 Nis

1/ Spatial transcriptomics is among the richest view of human biology that we have: 18,963 genes mapped at subcellular resolution. It's also almost never collected outside of research settings. So we trained a foundation model to generate it from a clinical H&E image alone. Meet TARIO-2. 🧵 noetik.blog/p/tario-2-a-wh…

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Ron Alfa@Ronalfa·3h

@EvanOwen 👋

QME

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Evan Owen@EvanOwen·3h

suddenly people who might want to follow me are seeing my posts. it's such a wild concept.

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Ron Alfa@Ronalfa·6h

Don’t get distracted by the doomers, AI is going to create jobs and drugs to cure disease. Congrats to Chai team.

Jack Dent@jackdent

Thrilled to announce our $400M Series C led by @IndexVentures, with @kleinerperkins, @sequoia, @_DimensionCap and others. Great to speak to @m_delamerced @nytimes about how drug discovery using AI is moving from a promise to actual deployment.

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Ron Alfa@Ronalfa·7h

@joshim5 @EricDai_BioE @chaidiscovery @IndexVentures @kleinerperkins @sequoia @_DimensionCap Massive! Congrats 🚀

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Joshua Meier@joshim5·7h

Tomorrow's medicines should be designed with the precision and scale of modern engineering. I'm thrilled that @ChaiDiscovery has raised a $400M Series C at a $3.8B valuation from @IndexVentures @KleinerPerkins @Sequoia @_DimensionCap to accelerate progress towards that goal.

Chai Discovery@chaidiscovery

We’ve raised $400M at a $3.8B valuation to further advance AI-driven molecular design. The round was led by @IndexVentures, alongside @KleinerPerkins, @Sequoia, @_DimensionCap, and others.

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Ron Alfa@Ronalfa·17h

@worldly_bee we're all just posting the same everything really

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worldly bee 🐝@worldly_bee·17h

@Ronalfa everyone in SF posting the same sunset lol

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Ron Alfa@Ronalfa·17h

Sunsetmaxxing

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Ron Alfa@Ronalfa·18h

@gama_search It was the right data for the time, but the wrong data for the current era.

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Felix Raimundo 🧬🇪🇺/acc@gama_search·18h

@Ronalfa Because let's be honest we don't need a new TCGA ;) (I mean it was amazing when it came out, but we're no longer in 2010s)

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Ron Alfa@Ronalfa·19h

cancer is a data problem

Craig Weiss@craigweiss

cancer is a computer science problem

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Ron Alfa@Ronalfa·19h

@adelbucetta depends on the density and nature of the data. can take a look at our reports, we are seeing strong results already.

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Adel Bucetta@adelbucetta·20h

@Ronalfa that's a tiny fraction of what it takes to make ai do anything meaningful in med. the real challenge is getting these models to generalize and translate to clinical practice.

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Ron Alfa@Ronalfa·1d

I mean, we have generated paired spatial data for 1000s of human tumors. From building a human tissue biobank from scratch, to generating mountains of expensive data, to training custom transformers.

Jake Wintermute 🧬/acc@SynBio1

Everyone wants to cure all diseases but nobody wants to do no hard ass biology experiments

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Ron Alfa@Ronalfa·1d

@Dremontjones 🙏🚀

QME

Dre@Dremontjones·1d

@Ronalfa Damn. Converting H&E to spatial genomics is amazing tech.

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Ron Alfa@Ronalfa·1d

@Dremontjones we also have a scaled in vivo CRISPR mouse perturbation system... because why not build 2 platforms at the same time!! noetik.blog/p/perturb-mars…

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Dre@Dremontjones·1d

@Ronalfa that’s pretty solid. Definitely a lot of valuable work. A lot. And human data is so so important. thank you. but where are the people developing and validating new model systems? everyone would rather do what’s easy and expedient (and not useful) than do what’s hard.

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Ron Alfa@Ronalfa·1d

Congrats @jackdent, @joshim5 and @chaidiscovery on another inked deal!

Jack Dent@jackdent

Chai’s year of deployment continues. Great to announce this collaboration with @Novartis today to support multiple therapeutic programs with our models, including Chai-3. It’s been incredibly rewarding to collaborate over the past year. Looking forward to expanding our work together.

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Ron Alfa retweetledi

Logan Kilpatrick@OfficialLoganK·2d

it’s surprising to me how many people seem to not understand that great models are built with super high quality curated data finding novel ways to create / get this data is a huge edge

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Ron Alfa@Ronalfa·1d

@michellearning 100%

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Michelle Lee@michellearning·1d

High throughput is not the bottleneck. Nicer UI and 5% more optimal dynamic scheduling is not the bottleneck. Natural language interface is not the bottleneck. Running more complex, informative, decision-relevant experiments and generating net new data at scale is.

Ron Alfa@Ronalfa

big pharma has been running cheap scalable high throughput experiments with robots for decades, more cell titer glow was never the problem

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Ron Alfa@Ronalfa·1d

@sethbannon Thank you for funding these moonshots and proving the investment thesis! 🚀

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Seth Bannon@sethbannon·1d

@Ronalfa Grateful for all you do to create a better future for us all!

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Ron Alfa@Ronalfa·1d

The constraint is not the set of us working on it against all odds.

Seth Bannon@sethbannon

Imagine if our smartest people competed to solve energy, manufacturing, disease, and science instead of marketing tools, online gambling, and yet another incremental AI product.

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Ron Alfa@Ronalfa·2d

@ninklefitz impressive, apparently I do not send 😂

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Nicole Fitzgerald@ninklefitz·2d

yeah ok you ship but do you send

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Keşfet

@EvanOwen @joshim5 @EricDai_BioE @chaidiscovery @IndexVentures @kleinerperkins @sequoia @_DimensionCap