Mac Kevin Braza

We developed a reproducible protocol to automate the equilibration of mesoscale all-atom lipid vesicles, with systems reaching 150M atoms. Grateful to @LCasalino88 and @RommieAmaro for their guidance and mentorship. Code: github.com/matteo-castell… Paper: pubs.acs.org/doi/10.1021/ac…

@_paulineracelis Pau!!! Ang pretty ng workstation mo!!! 😍🤩✨🌟

#HighlightOfTheWeek APOBEC3B (A3B) dynamics from classical molecular dynamics simulations. A3B is implicated in DNA mutations that facilitate tumor evolution. @RommieAmaro @MacKevinBraza @Ozlem__Dmr @ccalvotusell @LCasalino88 #compchem pubs.acs.org/doi/10.1021/ac…

Thrilled to be amongst this cohort of exceptional scientists receiving the Presidential Early Career Award for Scientists and Engineers (PECASE)!!!! @NSF #NSFCAREER #PECASE whitehouse.gov/ostp/news-upda…

AF3 code is now open source nature.com/articles/d4158…

Excited to share the first project from my postdoc. We studied a ligand bound TRPV1 cryo-EM dataset with state of the art heterotgeneity methods, and developed a way to compare them with a technique we call CryoSVD. paper doi.org/10.1101/2024.1… CryoSVD github.com/flatironinstit…

This doesn't detract from the accomplishments of Deepmind / AlphaFold. But, let's take time to remember that these amazing advances were possible because of #OpenScience and #OpenData: 🔹Support for databases (e.g., Protein Data Bank, UniProt, and many others) measured in decades, 🔹Development and community acceptance of a standard data format (i.e., the PDB), and 🔹The effort of thousands of researchers across decades in the lab, countless simulations run on leadership scale computing, and data collected at light source beamlines across the world

In our new study out in @NatureComms, co-led by @xandra_nuqui and myself, in collab. w/ @McLellan_Lab & @ChandranLab, we designed a 2W-stabilized SARS-CoV-2 S2 antigen exhibiting enhanced expression and preserved immunogenicity against sarbecoviruses. 👉 nature.com/articles/s4146…

New article just published. This work on small molecule p53 reactivators was in the making for almost a decade. Thanks to Maryam Fallatah, @ambuj_88, Prof Peter Kaiser and all contributors. mdpi-res.com/d_attachment/b…

New #lipidtime paper by phenomenal Chem Bio PhD student Adrian Wong on the development & application of four organelle-targeted derivatives of the solvatochromic dye Laurdan, the most commonly used probe for reading out membrane fluidity in cells pubs.acs.org/doi/10.1021/ac…

Certain enzymes play a crucial role in our body's inflammatory immune response, and now researchers from @UCSDChemBiochem have reported on the selectivity of these enzymes in macrophage cells, revealing new insights in treating disease. bit.ly/3W5SXrC

Having trouble visualizing your data from WESTPA? Try WEDAP! A user-friendly plotting package from @darianyang and @ltchong (1/4) pubs.acs.org/doi/10.1021/ac…

Our paper on the university-wide mentorship program @bummp_ucsd and its impact on students' sense of belonging, identity, and scientific efficacy is now out on a special DEI issue of Journal of Cellular Physiology! onlinelibrary.wiley.com/doi/10.1002/jc…

Today in @ScienceMagazine we report how lipids specialize for life under the crushing pressures of the deep sea and what this means more broadly for the composition of cell membranes (1/n) science.org/doi/10.1126/sc…

Delighted to share that I will be speaking this Friday, June 28, 6PM Pacific time as one of the recipient of the UP Alumni Assoc in America (UPAAA) scholarship. They are instrumental in my success as a PhD student in UC San Diego. @upsystem 🇵🇭 😁

New issue! 📢 Discover nucleosome substrates, ligand sensing, nitrone formation, allosteric networks, and much more! ➡ go.acs.org/9Et Cover art: Torres-Paris et al. investigate how the linker region of muPA affects protease activity 🐁 ➡ go.acs.org/9Es

pix2tex is a #Python library that allows you to convert images of equations into LaTeX code. This allows you to incorporate an equation from a document into another document without recreating the equation from scratch. github.com/lukas-blecher/…

As of 11 am, Kanlurang Mayao, Lucena City, #Quezon #AghonPH

This is how our province looked like now bcoz of typhoon. #AghonPH #Ewiniar

Nabagsakan din ng mga sanga ang kawad ng kuryente sa College of Forestry and Natural Resources at nagkalat naman ang mga dahon at sanga sa ibang bahagi ng UPLB Campus dahil sa Tropical Depression "Aghon". Video mula kay Lui #AghonPH #BagyongAghon #UPLBupdates