Aoise O'Neill

Such a friendly forum at IACR this year. Delighted to have the opportunity to present my work to such a great audience 🥳 congrats @NiamhLeonard5 ☺️

Researchers at the University of Galway have revealed the results of a world-first study into how bowel cancer shuts down the immune system, and how this can be reversed to improve treatment. 🧬 Professor in Tumour Immunology at @galwaycmnhs Aideen Ryan, stated that unlike in melanoma and lung cancer, immunotherapy has had limited success in treating bowel cancer, leaving advanced-stage patients with few options and poor survival rates. The breakthrough research discovery is the first to demonstrate that tumour stromal cells, which support cancer growth, are directly reprogramming the immune system. 🧫 These cells are coated in sialoglycans that bind to Siglec receptors on immune cells, switching off the body’s natural defences and making immunotherapy ineffective. Read more 👉 jitc.bmj.com/lookup/doi/10.… @aideenryan1 @researchirel @IrishResearch @BreakthroCancer @QuBelfast #UniversityofGalway #CancerResearch #MedicalResearch

If you are interested in the role of sialylation in mediating stromal cell immunosuppression check out our new review led by @OAoise We explore the role of the Sia/Siglec axis within stromal-rich, immunosuppressive TMEs. @MichaelodwyerMD onlinelibrary.wiley.com/doi/10.1002/ej…

A St Patrick’s Day treat ☘️ More excellent work from @aideenryan1 and her team, teasing apart the importance of stromal & immune communication networks in colorectal cancer 👇

Exciting news from #ASH24! Palleon contributed to new research showing promising ways to enhance treatment for #MultipleMyeloma. Honored to work with @MichaelodwyerMD & @aideenryan1 in advancing options for those fighting this disease. 🔗 bit.ly/4fUFw6L

Congratulations @NiamhLeonard5 on leading on our study to help us better understand CRC tumour microenvironments that are resistant to current treatments @Researchirel @Uni_Galwaypress @GalwayCMNHS @CancerUniGalway. This was certainly a team effort @aisling_hogan @olivertreacy1

Could patients with stromal rich, CMS4 colorectal cancer benefit from innate immune targeting therapies? See our new paper exploring the complexe TME in CMS4 tumours, combining syngenic animal models, 3D culture systems and patient samples/datasets cell.com/iscience/fullt…

@shazglynn @aideenryan1 @scienceirel @CancerUniGalway @lambeinstitute Thank you Sharon! ☺️

@aideenryan1 @OAoise @scienceirel @CancerUniGalway @lambeinstitute Congrats Aoise! Wonderful news

Congratulations @OAoise on your Bright Sparks Award. Fantastic achievement! @scienceirel @CancerUniGalway @lambeinstitute

Had a great time at #ECI2024 with @aideenryan1 gang. Always greatful for the opportunity to present my work. Big well done to @OAoise @eileenreidy111 and @LeiLei2Galway on their presentations!

Fantastic few days at #ECI2024 with the @aideenryan1 lab gang 🥳 great immunology talks. Delighted to have the opportunity to present my work in the glycosylation workshop today and to receive a bright spark award @EFIS_Immunology @yISI_ie @scienceirel

🎉 Congratulations to #ECI2024 Bright Sparks winners! 👏 @EFIS_Immunology

@ThomasR55937842 Huge congrats jiemin!

Happy graduation 🎉. Very well done ✅. I can see a stellar career ahead. Best of luck with your future endeavours. 🤞

@aideenryan1 @scienceirel @CancerUniGalway @lambeinstitute Thanks Aideen!

such a great experience in #ECI2024 to share my work which is CAFs subpopulation immunomodulation in CRC. Very lucky that I can work with these wonderful people. Thanks @EFIS_Immunology travel grant for supporting my trip.

Presented today at #ECI2024 on developing a 3D model to assess stromal mediated effects on T cells in the CRC TME.Enjoyed great discussions about my project.Very greatful to have received a travel grant from @EFIS_Immunology/ @EurJImmunol. Looking forward to the talks tomorrow!

Congratulations to @NiamhLeonard5 on the publication of the final paper from her PhD in iScience. A truly collaborative effort @eileenreidy111 and @ShaniaMCorry @DrPipDunne @QubPGJCCR and Daniela Loessner @MonashUni cell.com/iscience/fullt…

Loving the #sustainable packaging from @miltenyibiotec 🥳 every small change adds up to make a big difference! #greenlabs #ClimateAction 🐸🦖🪴🌱🌍

Had a great day on Wednesday attending the @GalwayCMNHS research day. Was very motivational hearing about the research taking place through the college. Grateful to have received an award for the best rapid fire oral presentation.

Come join our teams @JoanneLysaght and I at @tcddublin and @uniofgalway for an exciting collaboration on immune checkpoint signalling in OAC. Great opportunity if you are interested in next generation anti-cancer immune therapies and collaborative research. @CancerUniGalway

Congratulations to the newest Dr in the Ryan lab @eileenreidy111. A privilege to work with Eileen on 3D CRC models, with co-supervisor @abhay_curam. Thanks to examiners Prof Jai Prakash, Dr Conall Dennedy and chair Prof Sharon Glynn @shazglynn @GalwayCMNHS @CancerUniGalway