Manav Pathania | @manavpathania.bsky.social

First Pathania Lab paper in @CD_AACR: bit.ly/3K5xA3J. We developed 16 mouse models of various subtypes of pediatric high-grade glioma— mirroring their different H3 mutant contexts, anatomical compartmentalizations and co-segregating partner alterations. Thread below 1/17

Anthropic cofounder says studying the humanities will be ‘more important than ever’ and reveals what the AI company looks for when hiring fortune.com/2026/02/07/ant…

We're seeking to fill two roles: a PDRA and an RA. These positions will investigate resistance mechanisms in brain tumour models using in vivo models, spatial omics, CRISPR. Please apply if previous experience aligns! Here is the RA job advertisement: shorturl.at/NVl1V

We're seeking to fill two roles: a postdoc and a research assistant. Both will focus on resistance mechanisms in brain tumour models using various approaches (in vivo, spatial omics, CRISPR). Please apply if this aligns with your previous experience! shorturl.at/hZ6mG

As promised, here's the deep dive on our recent article! Did you know the brain's "sewer drains" (dural sinuses) aren't passive pipes—they're dynamic, ruffling structures that actively guard immunity & regulate pressure? As both a co-author and President & Founder of @neurosimplicity, I am excited to spotlight this groundbreaking discovery from the McGavern lab @NIH_NINDS in @Nature. Our Imaging Suite helped map the amazing cranial & neurovascular connections in unprecedented 3D detail! 🧠🔬 Link: rdcu.be/e4A8i #Neuroimmunology #BrainImmunity

Nature research paper: Highly dynamic dural sinuses support meningeal immunity go.nature.com/4qVnxlm

Nature research paper: A disease model resource reveals core principles of tissue-specific cancer evolution go.nature.com/4cIrt5i

Step 1: Insert bacteria ("Wolbachia") into mosquitoes. Step 2: Release mosquitoes. Step 3: Watch Dengue rates plummet. Phenomenal results from Singapore. Link: tinyurl.com/59c9t67u, by Lim et al.

I am excited to share our latest preprint, in which we demonstrate that systemic hypoxia suppresses solid tumor growth. This has been a tremendous collaborative effort in the labs of @IshaHJain and @Genophoria at @GladstoneInst, @ArcInstitute, and @UCSF. biorxiv.org/content/10.648…

3 new reports @CellCellPress on the mechanistic underpinnings of multiple sclerosis and Epstein-Barr virus involvement cell.com/cell/fulltext/… cell.com/cell/fulltext/… cell.com/cell/fulltext/…

New Cell paper from the team that discovered glymphatic clearance (how your brain removes waste during sleep). Sleep hours DIDN'T predict brain cleaning. Neither did REM or deep sleep. They found what actually matters - and why some sleeping pills might undermine it 🧵

Please share or forward to anyone interested in joining our lab as a research assistant, details can be found via the link below shorturl.at/x0cSs

Please share or forward to anyone interested in joining our lab for a postdoc, details can be found via the link below shorturl.at/GMbW0

Thanks to all those who helped us get going in Cambridge and looking forward to getting stuck in at Oxford soon!

The Pathania lab will be moving to the Ludwig Institute in Oxford in early 2026. We'll be recruiting postdocs and research assistants soon, so keep an eye out for those job ads and reach out if you want to find out more about the science we have planned! shorturl.at/thpyK

Farewell for Carmo, RA extraordinaire! Good luck in your PhD at the Crick and thanks for all your hard work over the last 3 years!

'Night science' is what you do when you're not sure what's the question.

Prevention beats cure, which is why it's so exciting that Lenacapavir, a twice-yearly HIV preventative, just got approved for the first time (by the FDA) Why is it such a big deal? When trialled (in women in South Africa and Uganda) there were 0 HIV infections 🧵

I am excited to present our new study out in @NatureMedicine where we discover a novel synaptic protein biomarker to predict if and when someone will get Alzheimer’s disease dementia. Part 2/3 from my PhD work in the @wysscoray lab. 🧵1/12 Full study 🔗: nature.com/articles/s4159…

We are walking the Ullswater Way with @OscarsCharity in May. Learn more and donate here: justgiving.com/team/thalia #braintumours #childhoodcancer #cancer

Too many people take biomedical innovation for granted.