Cancer Discovery

The May issue is online. aacrjournals.org/cancerdiscover…

Presentation + Publication = Impact. Learn more about the power of simultaneous publication with the AACR Journals: vimeo.com/showcase/11942…

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News: Spatially Sussing Out the TME, No Tissue Needed doi.org/10.1158/2159-8…

News: First BCL-2 Inhibitor Approved for Mantle Cell Lymphoma brnw.ch/21x2K3l

Now online: Asynchronous evolution of epithelium and stroma differentiates precursor lesions from pancreatic cancer doi.org/10.1158/2159-8…

Now online: Senescent-like neutrophils shape angiogenic immunosuppressive niches in colorectal cancer liver metastasis doi.org/10.1158/2159-8…

News: Approval of First PROTAC Opens New Era for Targeted Protein Degradation brnw.ch/21x2BaE

ICYMI—did you know that 60 articles were presented at #AACR26 and published simultaneously in the AACR Journals? 📄Read the research: aacrjournals.org/pages/annual_m…

Now online: Rational Design of Immune Gene Therapy Combinations via In Vivo CRISPR Activation Screen of Tumor Microenvironment Modulators doi.org/10.1158/2159-8…

Now online: A Targetable Developmental Program Coregulates Angiogenesis and Immune Evasion in Melanoma doi.org/10.1158/2159-8…

Extracellular Glutathione Fuels Tumor Growth as a Cysteine Source doi.org/10.1158/2159-8… A #ResearchWatch summary of a recent study by Fabio Hecht, Isaac S. Harris and colleagues.

Sialylated CD43 Shields AML Cells from Antitumor Immune Responses doi.org/10.1158/2159-8… A #ResearchWatch summary of a recent study by Jooho Chung, Mounica Vallurupalli, Todd R. Golub, Robert T. Manguso and colleagues.

Now online: Mismatch Repair-Proficient Colorectal Cancer can evade Immune Surveillance Through an Intrinsic Suppressive Program doi.org/10.1158/2159-8…

Now online: A Spatial Atlas of Muscle-Invasive Bladder Cancer Reveals Lineage-Specific Vulnerabilities and Immune Architecture doi.org/10.1158/2159-8…

Now online: Machine Learning Predicts Hepatocellular Carcinoma Risk from Routine Clinical Data: A Large Population-Based Multicentric Study doi.org/10.1158/2159-8…

Autoimmune Response to NMDAR Supports Immunosurveillance of Cancer doi.org/10.1158/2159-8… A #ResearchWatch summary of a recent study by Sam O. Kleeman, Sarosh Irani, Hiro Furukawa, Tobias Janowitz and colleagues.

Engineered Catch Bonds Overcome T-Cell Tolerance in Cancer Therapy doi.org/10.1158/2159-8… A #ResearchWatch summary of a recent study by Xiaojing Chen, Zhiyuan Mao, Owen N. Witte, K. Christopher Garcia and colleagues.

Proteasome–Heme Axis Links Mitochondrial Stress to T-Cell Exhaustion doi.org/10.1158/2159-8… A #ResearchWatch summary of a recent study by Yingxi Xu, Jianxiang Wang, Ping-Chih Ho and colleagues.

Reactivation of Fetal Morphogenesis Signals Predicts Breast Cancer Metastasis doi.org/10.1158/2159-8… A #ResearchWatch summary of a recent study by Robin Caire, Massimiliano Pagani, Michelangelo Cordenonsi, Stefano Piccolo and colleagues.

Synthetic Super-Enhancers Allow for Precise Antitumor Therapy doi.org/10.1158/2159-8… A #ResearchWatch summary of a recent study by Ute Koeber, Steven M. Pollard and colleagues.