Pelletier Lab

80 posts

Pelletier Lab

Pelletier Lab

@PelletierLab

Beigetreten Temmuz 2011
120 Folgt220 Follower
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Iva Tolić
Iva Tolić@Toliclab·
Chromosomes stuck behind the spindle are ticking time bombs for aneuploidy. We uncovered a mechanical rescue mechanism where microtubule pivoting repositions these high-risk chromosomes! Out last week in @NatureComms, here's a thread 🧵 shorturl.at/OD89x
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kipling_r
kipling_r@kipling___r·
@tigerhzjian Consider collab. w. Arlotta Lab, (Harv.) they have had multi-cell organoids (neuro) for some time + are prob. interested in implementing vascularization. Best of luck!
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Sinai Health
Sinai Health@SinaiHealth·
Congratulations to Dr. Keiran Campbell, investigator at LTRI, on receiving the Canadian Society of Molecular Bioscience’s New Investigator Award (@CSMB_SCBM), recognizing his achievements and leadership in computational cancer biology 👏 #SinaiHealth #LTRI #CancerResearch
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Raffaele Di Giacomo, PhD
This is fascinating! By introducing physiological vascular flow in vitro, you're opening new avenues for understanding how hemodynamic forces shape vascular architecture. Have you observed any significant differences in the vascularization of organoids compared to native tissues? And how might these insights help in developing treatments for Hereditary Hemorrhagic Telangiectasia? For more on such exciting biomedical topics, check out Sci-Quest, a one-stop platform to generate comprehensive reviews: sciqst.com #VascularBiology #Medicine #BiomedicalResearch
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Felipe Del Valle
Felipe Del Valle@coffee_lipe·
First time I’ve seen real scientific figures that look like those absurdly inaccurate magical science clips shown in movies or tv series. Kudos to the authors for making them so attractive! -and for their paper, of course-
Tiger Jian@tigerhzjian

(1/6): How can we better test therapeutics without using animals or risking lives? Lab-grown human mini-organs, called “organoids”, provide an answer! Despite their progress, organoids and related methods lack realistic flow through blood vessels, the “plumbing” of our bodies.

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Lior Golgher
Lior Golgher@LiorKir·
@tigerhzjian Cool! You could likely use in silico models made by Peter Balogh and Prosenjit Bagchi to predict capillary dynamics and RBC partitioning, then use your vascularized organoids to test their predictions. @PBNeuroVascLab
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Dr. Richard
Dr. Richard@richnanophd·
@tigerhzjian Exactly what the field needs! Without vascular flow, organoids lack critical mechanical cues. Your pump-integrated platform solves this with elegant simplicity. Outstanding work! 👏
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Tiger Jian
Tiger Jian@tigerhzjian·
(1/6): How can we better test therapeutics without using animals or risking lives? Lab-grown human mini-organs, called “organoids”, provide an answer! Despite their progress, organoids and related methods lack realistic flow through blood vessels, the “plumbing” of our bodies.
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Pelletier Lab
Pelletier Lab@PelletierLab·
(1/7): New preprint from the lab! We generate physiological vascular flow in vitro to vascularize organoids, interrogate the effects of hemodynamic forces on vascular architecture, and model the disease Hereditary Hemorrhagic Telangiectasia.
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