Pablo Blinder

@altryne Same issue here...

PSA: If you've been running out of Claude session quotas on Max tier, you're not alone. Read this. Some insane Redditor reverse engineered the Claude binaries with MITM to find 2 bugs that could have caused cache-invalidation. Tokens that aren't cached are 10x-20x more expensive and are killing your quota. If you're using your API keys with Claude this is even worse. This is also likely why this isn't uniform, while over 500 folks replied to me and said "me too", many (including me) didn't see this issue. There are 2 issues that are compounded here (per Redditor, I haven't independently confirmed this) : 1s bug he found is a string replacement bug in bun that invalidates cache. Apparently this has to do with the custom @bunjavascript binary that ships with standalone Claude CLI. The workaround there is to use Claude with `npx @anthropic-ai/claude-code` 2nd bug is worse, he claims that --resume always breaks cache. And there doesn't seem to be a workaround there, except pinning to a very old version (that will miss on tons of features) This bug is also documented on Github and confirmed by other folks. I won't entertain the conspiracy theories there that Anthropic "chooses" to ignore these bugs because it gets them more $$$, they are actively benefiting from everyone hitting as much cached tokens as possible, so this is absolutely a great find and it does align with my thoughts earlier. The very sudden spike in reporting for this, the non-uniform nature (some folks are completely fine, some folks are hitting quotas after saying "hey") definitely points to a bug. cc @trq212 @bcherny @_catwu for visibility in case this helps all of us.

@Ra1kshit @claudeai Similar experience here on the Pro plan. This token issue started just a couple of days ago for me.

Claude code is essentially unusable for me i hit 36% session limits in 15 mins. Just by using a single agent on my codebase. @claudeai you need to fix it. I'm on the 100$ plan btw

Excited to share this work with an amazing team: @KarlDeisseroth @BrunetLab @Ravi__Nath @scott_linderman Libby Zhang Paper in Science: science.org/doi/10.1126/sc…

Preprint! 🚨 “Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature” This project took an unexpected turn when we discovered that #pericytes have primary #cilia! 🔗 biorxiv.org/content/10.110… 🧵1/8

Excited to share our new paper published @NeuroCellPress! We used voltage imaging combined with optogenetics in 4 major hippocampal cell types to study how the behavioural state modulates their firing, subthreshold dynamics, and gain authors.elsevier.com/a/1mego3BtfHD0…

🚨 Postdoc position in my lab @calico is live! I'm looking for someone deeply curious about the aging brain🧠⌛️, who wants to build novel scientific projects from scratch and carry them to publication and, ideally, into their own lab🥼🧪. No neuroscience background needed.

Cortical microglia promote noradrenergic signaling to maintain wakefulness

Bottom line: We may have been measuring the wrong things about sleep. Total hours, REM percentage, deep sleep duration - none predicted brain cleaning as well as norepinephrine pulse frequency did. cell.com/cell/fulltext/…

FACED 2.0: a method for high-speed, large FOV, volumetric 2-photon voltage and calcium imaging in the mouse and zebrafish brain. nature.com/articles/s4159…

🚀 We’re hiring! Staff Scientist / Postdoc – Tissue Clearing & 3D Image Analysis (m/f/d) (LMU Munich) Are you a great fit, or do you know someone outstanding, please reach out 🔁 If you want to at the frontier of whole-organ / whole-body 3D imaging, and help generate truly beautiful datasets that drive major biological discoveries and therapeutic development, see below ✨ We’re building the next-generation pipeline for tissue clearing + light-sheet microscopy + quantitative 3D analysis in the SyNergy Excellence Cluster (Mesoscale Hub) and we’re looking for someone excited to push this forward with us. 🧠🔬📈 🎥 I’m also attaching a short video showing the kind of high-quality imaging and datasets you’d be working with. What you’ll do 🛠️ 🔹 Lead and evolve tissue clearing + light-sheet workflows across collaborative SyNergy projects 🔹 Turn complex 3D datasets into robust quantitative insights (visualization, atlas registration, readouts) 🔹 Develop new methods and analysis pipelines together with our AI team 🤖 🔹 Maintain and optimize cutting-edge light-sheet systems (optional: support animal license writing) What we’re looking for 🎯 ✅ Strong hands-on experience in tissue clearing and/or fluorescence microscopy ✅ Solid experience with light-sheet microscopy and 3D imaging workflows ✅ Familiarity with 3D tools like Imaris / arivis Vision4D, stitching (e.g., BigStitcher), and quantitative analysis in cleared tissues ✅ Service mindset, great organization, and strong scientific English How to apply 📩 Apply via the LMU Klinikum online application form lnkd.in/gCgdaJuV Please also send your application to: farida.hellal@med.uni-muenchen.de CC: ali.ertuerk@med.uni-muenchen.de 📎 Include one PDF: short cover letter, CV, 2–3 referees, and earliest start date. 📍 Campus Großhadern (Munich) and Helmholtz Munich | 🕒 Full-time | 📅 Start: 01 January 2026 If you love high-quality imaging, cutting-edge biology, and building something that will matter, we’d love to hear from you. 🌍✨ #hiring #StaffScientist #Postdoc #TissueClearing #LightSheetMicroscopy #ImageAnalysis #SpatialBiology #Neuroscience #SyNergy #LMU #Munich

The neural computation of affective internal states in the hypothalamus: A dynamical systems perspective: Neuron cell.com/neuron/fulltex…

Neuroscientists record two main data modalities: electromagnetic waves and Spiking activities. A longstanding debate in neuroscience is whether the brain waves are essential for understanding how the brain works, or are they merely epiphenomenal. In more scientific terms, do the waves carry a causal influence on the behavior when spiking activities are recorded? When I first heard about this from @ZabehErfan I assumed neuroscientists are already discussing in causal inference terms; turns out that it is not quite the case. Each neuroscientist has their own qualitative beliefs/knowledge about the brain mechanisms, but to our surprise, they are not using the causal inference semantics to express it. The debate is not settled despite decades of advancement in recording technologies and statistical modeling breakthroughs, and it is not too surprising from a causal inference perspective: due to Causal Hierarchy Theorem (@eliasbareinboim et al. 2020), no amount of data alone can identify the causal quantities. Thus it is necessary to use a formal language to express the qualitative knowledge, and @yudapearl’s do-calculus is precisely the syntax and semantics we need to settle the spike-wave duality. In particular, we ground the discussion in Structural Causal Models, and boil down the epiphenomenality claim to assessing a certain inequality: P(behavior | spikes) ?= P(behavior | spikes, do(waves)) Once the qualitative domain knowledge is properly expressed in causal terms, e.g., a semi-Markovian causal graph, then a graphical criterion for epiphenomenality can be derived. Grounding the discussion in causal language sheds light on many hidden aspects of the problem, even if the debate remains unsettled: 1. What is the inference bottle neck? Is it the amount of data, regimes of data, scope of measurements, or the statistical modeling methods? 2. Data-driven knowledge discovery: what can be said about the causal graph using the data? which forms of heterogeneity and surrogate interventions are useful? If you’re at @NeurIPSConf come check out our poster along many other cool work at @CauScien workshop!

Fascinating work! Big kudos Mark and team!🥂

@elonmusknews30 A

@PiatkevichL @yulonglilab Great! Already in contact with BrainCase (mail went into junk inbox...). We wilk try the BC-4389 rAAV-hSyn-DIO-NES-SomaFRCaMPi. Thanks!

@PBNeuroVascLab @yulonglilab Thank you! All plasmids are available for free from WeKwikGene wekwikgene.wllsb.edu.cn/publications/1… High-quality AAVs can be ordered from here ebraincase.com/products-servi…

Great commentary by @yulonglilab on our two recent papers introducing red genetically encoded biosensors for calcium and potassium imaging! 🔴 FRCaMPi - Enhanced red calcium sensor 🔴 RGEPOs - First-ever red potassium sensors 📖 doi.org/10.1371/journa…

@DaniBeckman Beautiful image! How does it compare with a- NG2?

Testing some new antibodies to identify oligodendrocytes 🟣, for me, the most difficult one to target in brain microscopy! Here, I was able to identify its nuclei but not the whole cell body like neurons 🟡or microglia 🔵. Still, you can see oligos are everywhere! #Neuroscience

@OdedRechavi Already "analyzing"... can't wait to see the breakdown etc...paper classified as "Neuroscience", let's see!

@PBNeuroVascLab Yes!!! 🙌 thanks Pablo, tell me how it went! (You can also read with it)

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 It started from my frustration with the depressing effect that the current publishing system has on the well-being of myself, my team, and pretty much every scientist I know (maybe you’ve noticed from my stupid jokes… :) I was exhausted of dealing with the huge delays, reviewers that can be abusive, and how arbitrary it all is. Unfortunately, the most important factors are often WHO your reviewers are and who YOU are... It’s clear we need alternatives or at least ways to improve the situation. So, together with a really special and talented team we worked to develop this idea into “qed” a platform where you can get CONSTRUCTIVE feedback on your own work or CRITICALLY assess other people’s papers. It can be a real difference maker if many of you join us (thousands have tried it already, but today we release a NEW and much stronger version ;) Let’s harness qed to put the power back in the scientists’ hands, to do, to read & to publish science on our own terms. I’m dying for you to TRY IT, and it’s very simple - just drop a paper (the link to the website is in the replies👇) - it’s completely secure, private, and free, and you get results fast. Please show your support, SHARE, tell your friends, and let’s be the revolution 🫵!