Ragusa Lab

The RagusaLab is now on Bluesky. Come check us out at bsky.app/profile/ragusa…

Our new preprint is out: we solved the structures of HIV-1 matrix (MA) from intact virions by SPA. The structure led us to a surprising discovery resolving a long mystery in HIV-1 biology – peptide SP2 regulates the maturation of the HIV-1 matrix. 🧵1/x tinyurl.com/c7szhtfa

We get so focused on research it can be hard to take a step back and listen to other peoples stories. Check out @dartmouth postdoc @SukrutKamerkar's excellent perspective on supporting one another, published in @ScienceMagazine . science.org/content/articl…

It's known that anionic lipid charge enhances alpha-synuclein's ability to bind membranes. But did you know that alpha-synuclein can preferentially bind to neutral membranes when they are full of packing defects? Read about it in our latest preprint!

Come check us out at booth 1131 for a research-immersive trainee-focused postbac program with an emphasis on wellbeing! @ABRCMS!! #ABRCMS

Pleased to see our paper now published in Autophagy Reports! Great work from all involved to discover more about how "protein ATG8ylation" works. The big question is still "why?" "ATG5 is dispensable for ATG8ylation of cellular proteins" #abstract" target="_blank" rel="nofollow noopener">tandfonline.com/doi/full/10.10…

Come be my colleague! @DartmouthChem has an opening for an Associate/Full Professor in Materials Chemistry: apply.interfolio.com/152869

Our work on the biochemical reconstitution of mitophagy initiation led by @Devika_An has been updated on bioRxiv. You can check it out at biorxiv.org/content/10.110…

Can you reconstitute tethering using three-color imagining to monitor protein localization at tethering sites in vitro? Yes! Can you distinguish between membrane binding and tethering with a single assay? Yes! Can you monitor tethering in real-time? Yes!

New paper up on bioRxiv biorxiv.org/content/10.110… Awesome work from @Devika_An demonstrating what types of tethering you can reconstitute with GUVs and liposomes in vitro. She also shows that Atg11 can bind some membranes and recruit them to Atg32 coated GUVs.

@jmdelgado_ @embojournal Congrats Jose! It's been fantastic getting to see this work evolve over the years.

Last week I had the opportunity to present my main thesis work at #KSautophagy24 in Keystone, CO. Today, that work is finally published online @embojournal! embopress.org/doi/full/10.10…

I am very happy our DFCP1 story is out! Since many years, DFCP1 has been used as an omegasome marker, but its function was totally unknown. Here we show that DFCP1 is an ATPase required for selective autophagy. Here are the main points of the paper: 1/8

@chemgonzalezlab @DartmouthChem Welcome Miguel! Looking forward to seeing you around Burke. Also just checked out your lab website and it looks awesome.

Excited to announce that the Gonzalez Lab (chem-gonzalezlab.com) will open its doors when I join @DartmouthChem as an Assistant Professor of Chemistry in Fall 2023! (1/3)

Very happy to see our paper now online. Great work from Wenxin, Taki and our fantastic colleagues #autophagy #crick @wencyzh @Sci_Lipi doi.org/10.7554/eLife.… @eLife

Huge congratulations to these three awesome Ragusa Lab Ph.D. students who all returned to Hanover to participate in graduation last weekend. Congratulations Dr. Bauer, Dr. Leary and Dr. Reinhart!

Have a Ph.D. in organic chemistry but want to gain experience applying data science to reaction development? The Read Lab @DartmouthChem is hiring a postdoc! See readlaboratory.com for more info. Please RT. #chempostdoc

Our paper is out! Congratulations to @Cassandra_Hayne @TheHayneLab @RobinStanleyLab at @NIEHS ! I had fun image processing this project! nature.com/articles/s4159…

Super excited to share a review article by @Nguyen_T_Hieu and myself on Substrate and phosphorylation site selection by PPPs! sciencedirect.com/science/articl…

.@tjolivas, Yumei Wu, @shenliang_yu, @TJ_MeliaLab et al. @YaleCellBio show that ATG9 vesicles are the membrane seed for mammalian autophagosomes using nanodisc technology bit.ly/3LBlFg4 @PDClab @GuptaLab1 @1in_1uan @em_guinn @ShantaNag1 #autophagy