De Camilli Lab

The De Camilli lab account has moved to Bluesky: PDC-Lab.bsky.social

Bridge-like lipid transfer protein 3A (BLTP3A) is associated with membranes of the late endocytic pathway and is an effector of CASM biorxiv.org/content/10.110…

A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell–cell contacts rupress.org/jcb/article/22…

Overlapping role of synaptophysin and synaptogyrin family proteins in determining the small size of synaptic vesicles biorxiv.org/content/10.110…

Our new preprint reveals that the interaction of the bridge-like lipid transport protein VPS13A with the lipid scramblase XK at ER-plasma membrane contacts in K562 cells correlates with erythroid differentiation @ChaseAmos15 @YaleCellBio @YaleNeuro biorxiv.org/content/10.110…

Our review on RBG motif bridge-like #lipid transport proteins of the VPS13-ATG2 family is now out in Annual Reviews of Cellular and Development Biology @AnnualReviews @YaleCellBio annualreviews.org/doi/abs/10.114…

Our collaborative study with the Cao lab at Duke-NUS reporting the synergistic pathological defects of mutations in synaptojanin 1 (Synj1) and auxilin (DNAJC6), two Parkinsonism genes, is now published.

Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology nature.com/articles/s4153…

Our paper demonstrating the segregation of synaptic vesicle proteins from ATG9 when expressed in fibroblastic cells, and their properties to be clustered in different condensates by synapsin, is now out in Nature Communications @YaleCellBio @YaleNeuro nature.com/articles/s4146…

And finally on Tuesday, Michael Hanna’s @lifecerealmikey poster (P2715; B327) on lipid channeling proteins that control endocytic traffic and then his talk at the minisymposium on Membrane trafficking and Organelle Homeostasis at 430pm in room 146B.

On Tuesday, check out posters from Mick Park @Sophistarete about axonal transport and synapse formation (P2789; B403) and Daehun Park @eoqkr159 (P2807; B421) about synaptic vesicle phases,

Check out the De Camilli lab at #CellBio2022! @ASCBiology @YaleCellBio

Our review for Cold Spring Harbor Perspectives in Biology on the role of lipid transport proteins at ER-contacts sites in neurodegenerative disease is now on line. cshperspectives.cshlp.org/content/early/…

Check out our lab's newest work from @HaniehFalahati! Proximity proteomics of synaptopodin provides insight into the molecular composition of the spine apparatus of dendritic spines @YaleNeuro @YaleCellBio pnas.org/doi/10.1073/pn…

Our paper describing VPS13A interaction with XK at ER-PM contact sites is now out on PNAS: doi.org/10.1073/pnas.2… @AGuillenSaman @YaleCellBio @YaleNeuro @KavliAtYale

Membrane remodeling properties of the Parkinson’s disease protein LRRK2 biorxiv.org/content/10.110…

Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates biorxiv.org/content/10.110…