ShorterLab

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration: science.org/doi/10.1126/sc…

Thank you Sandy @MadayLab , for a wonderful seminar and great discussions!

Gooooood night Philadelphia!

AC Immune's experimental PET tracer detected toxic TDP-43 protein clumps in the brains of ALS patients in a Phase 1 clinical trial. buff.ly/hsMXiCX #ALS #ALSNewsToday #Bionews #ALSCommunity

amyloid-predict and LLPS-predict: Predicting phase separation propensities in the intrinsically disordered proteome | PNAS pnas.org/doi/10.1073/pn…

Tubulin flux at spastin-induced nanodamage sites regulates microtubule rescue frequency and EB1 lifetimes | PNAS pnas.org/doi/10.1073/pn…

TPPP/p25 amyloid seeding activity as a specific biomarker for multiple system atrophy: Cell cell.com/cell/fulltext/…

Uncovering the initial response: Intra-mitochondrial surveillance activates the UPRmt: Molecular Cell cell.com/molecular-cell…

Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation: Cell Reports cell.com/cell-reports/f…

ICYMI: A recent publication from Dr. Eddie Lee, @TNRLab, "Performance of traumatic encephalopathy syndrome criteria in identifying individuals with chronic traumatic encephalopathy" was shared in @NatureMedicine Check it out 🔬: nature.com/articles/s4159…

ft. Katie Copley, Ashleigh Smirnov, Leland Mayne, @M_Linsenmeier, @JackRubien, @YSPTSPS, Bo Lim Lee, Hana Odeh, Longsheng Lai, @yiweichang Ben Black & @ShorterLab (@BB_UPenn) @ScienceMagazine science.org/doi/10.1126/sc…

Winnin' out west #RingTheBell

we honor those who fought for our country and made the ultimate sacrifice.

Today, we remember and honor all those who gave their lives for our freedom 🇺🇸

Today and every day, The City of Philadelphia honors all who have served in our nation's military. City offices will be closed today in observance of Memorial Day. Offices will reopen on Tuesday, May 26. * Collections will be one day behind schedule for the rest of the week.

Check out this Q&A by @ALSTDI highlighting Dr. Katie Copley, a Corsalex Postdoc Fellow in our lab @YaleNeuro! The Coralex Postdoctoral Fellowship program is open for application: corsalex.com/corsalex-fello…

Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer’s disease progression: link.springer.com/article/10.103…

The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis: nature.com/articles/s4225…

Structural basis of signal peptide recognition by the signal peptidase complex: nature.com/articles/s4146…

Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons | Science Advances science.org/doi/10.1126/sc…

Our article of ATF2 and neuron apoptosis was picked up by the LA times 🤯 latimes.com/live-well/long…